Abstract：
:Despite insights into an increasingly significant role for delta opioid receptors in thermoregulation, it is unclear whether delta receptors located in the brain or periphery play the more critical role in body temperature regulation. Moreover, it is not entirely clear which delta receptor phenotype, delta1 or delta2, mediates the hypothermic actions of delta agonists. Because SNC-80 distributes into central and peripheral compartments and produces rapid hypothermia following systemic injection, the nonpeptide delta agonist is particularly useful in discriminating the site of action of delta receptor-mediated hypothermia. To determine the locus and phenotype of delta receptor which mediates SNC-80-induced hypothermia, we injected SNC-80 and phenotype selective delta antagonists to male Sprague-Dawley rats. SNC-80 (10-50 mg/kg, im) evoked hypothermia that peaked 30 min post-injection. Naltrexone (5 mg/kg, sc), an opioid antagonist, or naltrindole (5 mg/kg, sc), a delta antagonist, blocked the hypothermic response to SNC-80 (35 mg/kg, im). The hypothermia caused by SNC-80 (35 mg/kg, im) was blocked by a delta2 antagonist, naltriben (2.5 mg/kg, sc), but was not affected by BNTX (5 and 10 mg/kg, sc), a delta1 antagonist. The administration of naltriben (10 microg/rat, icv) 30 min before SNC-80 (35 mg/kg, im) prevented SNC-80-evoked hypothermia. In contrast, methylnaltrexone (5 mg/kg, sc), a peripherally restricted opioid antagonist, did not affect the hypothermia caused by SNC-80. The present data demonstrate that selective activation of brain delta2 receptors is a major mechanism of SNC-80-evoked hypothermia in rats.
journal_name
Brain Resjournal_title
Brain researchauthors
Rawls SM,Hewson JM,Inan S,Cowan Adoi
10.1016/j.brainres.2005.04.074subject
Has Abstractpub_date
2005-07-05 00:00:00pages
61-9issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(05)00683-9journal_volume
1049pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:This study examined the temporal appearance of c-fos expression in rat cerebella from birth to postnatal day 21 (P21) and following systemic kainic acid administration in adults. During development, Fos positive granule cells appeared first at P3 in caudal lobules and extended to all folia by P9. These reactive cells ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00263-7
更新日期：1998-06-08 00:00:00
abstract：:After studying pathway selection in the brain of Rana pipiens during unilateral optic nerve regeneration, several frogs were allowed to survive for lengthy periods for use in the present investigation. Retina flat-mounts were prepared from both eyes at 42-50 weeks postoperation. In some cases, HRP was infiltrated into...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90804-2
更新日期：1985-10-07 00:00:00
abstract：:Activation of serotonin neurotransmission produces increase of plasma oxytocin, prolactin, vasopressin and ACTH levels. Using dual-immunocytochemistry, the number of oxytocinergic neurons in the hypothalamic magnocellular nuclei co-storing Fos after administration of D-fenfluramine was found to be 15-fold higher compa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01953-8
更新日期：1999-12-18 00:00:00
abstract：:Glia represents the most numerous group of nervous system cells and CNS development and function depend on glial cells. We developed a purified Muller glia culture to investigate the expression of several neurotransmitter markers on these cells, such as dopaminergic, cholinergic, GABAergic and peptidergic receptors or...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.01.031
更新日期：2005-03-21 00:00:00
abstract：:We have recently characterized the histopathological changes in an experimental model of mesial temporal lobe epilepsy (MTLE) induced by the intrahippocampal injection of low dose of kainate in mice. Although cerebral metabolism and blood flow are extensively studied and used in human MTLE to locate the regions involv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02092-2
更新日期：2000-01-10 00:00:00
abstract：:Maternal cigarette use during pregnancy is associated with increased incidence of neural impairments in offspring, but nicotine's unique contribution to any neuropathology remains unclear, and nicotine's neurodevelopmental effects assessed in animal models vary with concentration. During ontogenesis, the chick oculomo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.11.070
更新日期：2004-03-12 00:00:00
abstract：:Whether functional changes of the non-primary motor areas, e.g., dorsal premotor (PMd) and supplementary motor (SMA) areas, after stroke, reflect reorganization phenomena or recruitment of a pre-existing motor network remains to be clarified. We hypothesized that cellular changes in these areas would be consistent wit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.04.052
更新日期：2012-06-29 00:00:00
abstract：:The expression of the immediate-early gene c-fos was used as a marker of neuronal activity to investigate the cervical spinal interneuron populations involved in the corticomotoneuronal pathway. Adult rats received unilateral kainate injections in the forelimb area of the primary motor cortex. After a survival period ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00365-4
更新日期：1996-06-24 00:00:00
abstract：:Recent pharmacological and morphological studies have raised the likelihood of a regulatory link between the neuropeptide Y (NPY) and beta-endorphin (beta-END) networks in the hypothalamus. To evaluate this link we have examined the effects of NPY administration on the in vivo release of beta-END by push-pull perfusio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01284-2
更新日期：1995-12-24 00:00:00
abstract：:Light microscopic double labeling immunocytochemistry for vasoactive intestinal peptide (VIP) and gonadotrophin-releasing hormone (GnRH) was carried out on the hypothalami of male and female rats. It was found that the number of VIP boutons that terminate on GnRH neurons and the percentage of GnRH neurons contacted by...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00208-x
更新日期：1998-06-08 00:00:00
abstract：:In vivo proton magnetic resonance spectroscopy was used to investigate intracerebral phenylalanine (Phe) concentrations in nine patients with classical phenylketonuria (PKU). The study included serial examinations (n = 31; plasma Phe levels: 0.47-2.24 mmol/l) of patients either receiving a Phe-restricted diet (200 mg ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01054-8
更新日期：1997-12-19 00:00:00
abstract：:In the laboratory rat, inhalation (30 s) of high (> 70%) CO2 concentrations resulted in short-term (1-3 min) anesthesia, followed by a prolonged (up to 60 min) mild antinociception. Exposure to 100% CO2 resulted in significant thermal (hot-plate, 52 degrees, and tail-flick) and mechanical (tail-pinch, 886 g force) ant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91888-0
更新日期：1994-03-21 00:00:00
abstract：:The neurotoxic effects of exogenous glutamate were studied in the rat cochlea. Glutamate-treated rats (4 g/kg/day i.p., postnatal days 2-9) exhibited electrophysiologically-measured elevations in high frequency thresholds usually associated with hair cell loss in the basal region of the cochlea. While surface preparat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90090-i
更新日期：1991-06-28 00:00:00
abstract：:The present study examined the effect of chronic paroxetine (10 mg/kg p.o., 21 days) on the 5-HT1B and 5-HT1D autoreceptors controlling 5-HT efflux in slices of rat ventrolateral geniculate nucleus. Electrically stimulated 5-HT efflux (10 pulses, 200 Hz, 0.1 ms, 10 mA) was measured using fast cyclic voltammetry. Peak ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00289-8
更新日期：1997-06-20 00:00:00
abstract：:An in vitro method was developed to separately visualize dopaminergic, noradrenergic and serotoninergic terminals in the cerebral, hippocampal and cerebellar cortices of the rat, by means of the glyoxylic histochemical fluorescence method. Animals were pretreated with alpha-methylparatyrosine to deplete catecholamine ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90770-9
更新日期：1978-05-19 00:00:00
abstract：:By using a proteomic approach, we found increased levels of carbonic anhydrase II (CA II) in the brain of Ts65Dn mice, a mouse model for Down syndrome (DS). Further immunoblot analyses showed that the levels of CA II are increased not only in the brain of adult Ts65Dn mice but also in the brain of infants and young ch...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.11.023
更新日期：2008-01-23 00:00:00
abstract：:17β-estradiol (E2 or estrogen) is an endogenous steroid hormone that is well known to exert neuroprotection. Along these lines, one mechanism through which E2 protects the hippocampus from cerebral ischemia is by preventing the post-ischemic elevation of Dkk1, a neurodegenerative factor that serves as an antagonist of...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2012.12.015
更新日期：2013-06-13 00:00:00
abstract：:To determine the involvement of the hippocampal regions in a operant-type delayed alternation task of short delay or long delay, microinjections of muscimol into the hippocampus were used for temporal inactivation during the behavioral test in each rat. Dorsal hippocampal inactivation impaired the correct ratio of lon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02084-4
更新日期：2001-03-23 00:00:00
abstract：:Mouse brain was found by immunoblot analysis to have a protein of Mr 23,000 (P23k) that was clearly different from recoverin and was labeled with an antiserum raised against the NH2-terminus of recoverin. P23k could not be detected by an antiserum raised against the COOH-terminus of recoverin. Blots with 45Ca demonstr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90676-z
更新日期：1992-02-07 00:00:00
abstract：:Traumatic brain injury (TBI) is one of the largest health problems in the United States and affects both cognitive and motor function. Although weakness is common in TBI patients, few studies have demonstrated a reduction in strength in models of brain injury. We have developed a behavioral method to measure volitiona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.07.039
更新日期：2014-09-25 00:00:00
abstract：:The effect of hippocampal kindling on neuronal and glial marker proteins was studied in the rat by immunochemical methods. In hippocampus, pyriform cortex and amygdala there was an increase in glial fibrillary acidic protein (GFAP), indicating reactive gliosis, and an increase in the glycolytic enzyme NSE, suggesting ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90791-9
更新日期：1990-10-29 00:00:00
abstract：:Rats reared on a diet in which choline is replaced with N-aminodeanol (NADE), undergo > 50% replacement of brain acetylcholine with acetylated NADE, a false cholinergic transmitter. We examined amounts of sleep and wakefulness in 7 littermate pairs of rats fed either NADE-substituted, or a choline control diet for > 1...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90492-6
更新日期：1993-11-26 00:00:00
abstract：:High (2.5-5 micrograms) doses of ventral tegmental morphine, which normally facilitate brain stimulation reward, were found to cause a complete cessation of bar pressing for brainstem stimulation in animals pretreated with systemic pimozide (0.175-0.35 mg/kg). It was hypothesized that the behavioral failure was due to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91402-9
更新日期：1989-01-16 00:00:00
abstract：:Traumatic brain injury (TBI) affects 2.8 million people annually in the United States, with significant populations suffering from ongoing cognitive dysfunction. Impairments in decision-making can have major implications for patients and their caregivers, often enduring for years to decades, yet are rarely explored in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.10.004
更新日期：2019-02-01 00:00:00
abstract：:The intracellular injection technique of HRP with simultaneous recordings of intracellular potential was applied to the crab X-organ-sinus gland peptidergic neurosecretory neurons. At least two classes of neurons were discriminated from the usual type of neurosecretory neurons morphologically as well as electrophysiol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90468-3
更新日期：1986-01-08 00:00:00
abstract：:The expression of adenylyl cyclase (AC) isoforms in the adult rat vestibular periphery was investigated using reverse transcription polymerase chain reaction (RT-PCR). AC II, IV and V mRNAs were expressed in both Scarpa's ganglion and vestibular end organs. In addition, in the vestibular end organs, an AC mRNA not pre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02007-2
更新日期：2000-03-24 00:00:00
abstract：:This study was conducted on unanesthetized rainbow trout equipped with two ECG electrodes and with an intracerebroventricular (i.c.v.) micro-guide. The ECG signal was recorded during three experimental sessions of 30 min and the heart rate variability (HRV) spectral analysis was performed during stabilized periods of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02903-7
更新日期：2002-08-23 00:00:00
abstract：:Simultaneous extracellular recordings from one electrode of 'local' groups of 3-6 neurons were obtained from the auditory cortex of unanesthetized, paralyzed cats. The activity and functional connectivity of local microenvironments were examined under various auditory stimuli. Single cell response patterns were examin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90567-x
更新日期：1983-08-08 00:00:00
abstract：:Parkinson's disease (PD) is a common neurodegenerative disease characterized by progressive loss of midbrain dopaminergic neurons. To gain an insight into the mechanisms underlying the progression of PD, gene expression analysis was performed using two different brain regions, the substantia nigra pars compacta (SN) a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.066
更新日期：2010-07-30 00:00:00
abstract：:Mutations in two genes, alpha-synuclein and parkin, have been identified as some rare causes for familial Parkinson's disease (PD). alpha-Synuclein and parkin protein have subsequently been identified in Lewy bodies (LB). To gain further insight into the pathogenesis of PD we investigated the role of neurofilament lig...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03138-4
更新日期：2002-09-27 00:00:00
