Abstract：
:We have developed a cell culture system for the rat suprachiasmatic nucleus, in which a clear circadian oscillation of vasopressin release was observed. Using this culture system, the effect of anisomycin, an inhibitor of protein synthesis, on the circadian rhythm was studied. A phase-delay of more than 15 h could be produced by a 6-h anisomycin pulse. The magnitude of the phase-shift was dependent on the circadian time of the drug treatment and on its dose. The phase-response curve was similar to the response curves that have been measured for protein synthesis inhibitors in other organisms. These results strongly suggest that protein synthesis may be involved in the generation of circadian rhythms in mammals.
journal_name
Brain Resjournal_title
Brain researchauthors
Watanabe K,Katagai T,Ishida N,Yamaoka Sdoi
10.1016/0006-8993(95)00414-lsubject
Has Abstractpub_date
1995-07-03 00:00:00pages
179-84issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(95)00414-Ljournal_volume
684pub_type
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