Abstract：
:Adult male rats, intact (N) or with complete (CHD), anterior (AHD), or posterior (PHD) hypothalamic deafferentations were bilaterally adrenalectomized. At 3, 6, 12 and 20 days post-adrenalectomy they were decapitated and trunk blood was collected for ACTH determinations. In N rats, ACTH markedly elevated up to 850 pg/ml. A similar ACTH response was found in PHD rats but the values were lower by approximately 20%. In contrast, in either AHD or CHD rats, ACTH responses were markedly attenuated and reached a plateau of about 350 pg/ml. These data suggest that: (1) neural inputs entering the medio-basal hypothalamus (MBH) from both the caudal and rostral directions are important for obtaining maximal ACTH responses following adrenalectomy; (2) at least part of this ACTH response is mediated by sites inside the MBH or in the pituitary.
journal_name
Brain Resjournal_title
Brain researchauthors
Weidenfeld J,Siegel RA,Conforti N,Chowers I,Feldman Sdoi
10.1016/0006-8993(84)90127-6subject
Has Abstractpub_date
1984-11-26 00:00:00pages
329-31issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(84)90127-6journal_volume
322pub_type
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