Abstract:
:In the hippocampus, pyramidal cells (PCs) are not the only cell type sensitive to cholinergic stimulation. Two non-pyramidal cell types from animals as young as 8 days demonstrated clear, direct responses to application of cholinergic agonists. These cholinergic actions are excitatory, mostly blocked by muscarinic antagonists, and persist under conditions which block synaptic transmission (TTX, low Ca2+/high Mg2+). Cholinergic agonists may affect different conductances in interneurons than in PCs, sometimes resulting in rapid depolarization. Demonstration of direct excitatory cholinergic effects on inhibitory interneurons supports the view that cholinergically-evoked hyperpolarizations in PCs are due to local circuit interactions.
journal_name
Brain Resjournal_title
Brain researchauthors
Reece LJ,Schwartzkroin PAdoi
10.1016/0006-8993(91)91688-wsubject
Has Abstractpub_date
1991-12-06 00:00:00pages
115-26issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(91)91688-Wjournal_volume
566pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The present studies examined the hypothesis that the N-methyl-D-aspartate (NMDA) receptor-nitric oxide (NO) pathway might be involved in the acute and chronic actions of delta 9-tetrahydrocannabinol (THC). The ability of dizocilpine (MK-801), a competitive NMDA receptor antagonist and NG-monomethyl-L-arginine (L-NMMA)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91715-9
更新日期:1994-12-19 00:00:00
abstract::EEG recordings of hippocampal theta activity and neocortical activity were correlated with direct observations and photographic recordings of the behaviour of unrestrained cats. The behaviour studied included (1) both spontaneous and induced changes in level of arousal (sleep-wakefulness), (2) different types of orien...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90110-9
更新日期:1975-09-23 00:00:00
abstract::We have studied magnetic and electrical fields of the brain in normal subjects during the performance of an auditory verbal short-term memory task. On each trial 3 digits, selected from the numbers 'one' through 'nine', were presented for memorization followed by a probe number which could or could not be a member of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90767-p
更新日期:1991-09-06 00:00:00
abstract::Histochemical investigation by means of light and electron microscopy revealed the presence of dipeptidylpeptidase IV activity in Meissner corpuscles of macaque glabrous skin. The enzyme activity was found in fibroblast-like cells forming an incomplete capsule around the Meissner corpuscle. Distinct electron-dense rea...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90739-1
更新日期:1988-09-27 00:00:00
abstract:BACKGROUND AND PURPOSE:The present study analyzed whether administration of sulindac, a non-steroidal anti-inflammatory drug (NSAID) would prevent, attenuate or repair ischemia induced brain injury and reverse functional impairment in a focal ischemia model of stroke. METHODS:Male Sprague-Dawley rats (weight 250-300 g...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.06.019
更新日期:2014-08-12 00:00:00
abstract::The amount of estradiol benzoate with progesterone required to induce lordosis in ovariectomized hamsters was determined to compare the responsiveness of hamsters to estradiol benzoate with that of rats and guinea pigs. In addition, the uptake and metabolism of tritiated estradiol in ovariectomized rats, guinea pigs...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(74)90193-0
更新日期:1974-05-10 00:00:00
abstract::The response properties of neurons in the region of striate cortex subserving central retina (0 degrees-2 degrees) and in a region of representation of parafoveal retina (4 degrees-7 degrees) were studied in unanesthetized paralyzed macaque monkeys. Neurons sensitive to the orientation of the stimulus in the visual fi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90240-1
更新日期:1975-12-12 00:00:00
abstract::The sympathetic preganglionic neurons in the spinal cord receive dense serotonergic (5-HT) and catecholaminergic (CA) afferent inputs from the descending supraspinal pathways. In the rat spinal cord, the levels of these biogenic amines and their receptors are low at birth, but undergo rapid ontogenetic increases in th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90231-7
更新日期:1985-03-01 00:00:00
abstract::Solid pieces of the fetal septal region (SG) or hippocampus (HPC) were implanted in a cavity formed by aspiration of the fimbria fornix (FF) and the overlying cingulate cortex on one side in adult rats. In other lesioned animals cell suspensions obtained from the fetal septal area (SS) or the locus coeruleus region of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90632-9
更新日期:1987-01-06 00:00:00
abstract::The petrosal ganglia contain the somata of the sensory fibers of the glossopharyngeal nerves, innervating structures of the tongue, pharynx, carotid sinus and carotid body. Petrosal ganglia were excised from adult cats and their neurons were dissociated and kept in tissue culture for 7-12 days. Intracellular recording...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02817-1
更新日期:2000-11-03 00:00:00
abstract::Chronic pain tends to be intractable, regardless of whether the etiology has improved or is persistent. This intractability may be due, in part, to conditioning factors, but studies of the underlying mechanism are limited. We predicted that the body might learn pain sensation during sustained pain. In the present stud...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.06.028
更新日期:2011-08-11 00:00:00
abstract::Histaminergic neurons of the tuberomammillary nucleus (TMN) are hypothesized to promote wakefulness, but little is known about the activity of these cells during spontaneous behavior. We measured histaminergic neuron activity in the dorsomedial, ventrolateral, and caudal TMN at four different times using Fos and adeno...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.08.044
更新日期:2003-12-05 00:00:00
abstract::Noradrenergic and dopaminergic regulation of thyrotropin (TSH) secretion was investigated in adult male Wistar rats. TSH secretion displayed a circadian variation with peak serum TSH levels at 10.00 h. The alpha 2-adrenoceptor agonist, clonidine (250 micrograms/kg, i.p.), was found to cause an enhancement of serum TSH...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91378-3
更新日期:1987-02-24 00:00:00
abstract::Various chemical and physical lesions were employed to elucidate the cellular localization of cholecystokinin (CCK) receptors in the rat caudate nucleus. A wide knife cut severing all caudal afferents reduced caudate CCK receptors by approximately 25%, indicating that some receptors lie on axons and (or) terminals of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90284-5
更新日期:1981-08-24 00:00:00
abstract::Hippocampal neurogenesis plays a very important role in learning and memory functions. In a search for best neurological drugs that protect neuronal cells and stimulate neurogenesis with no side effects, cannabinoids proved to be a strong group of substances having many beneficial properties. The aim of this study was...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.07.028
更新日期:2015-10-22 00:00:00
abstract::It is suggested that altered neuroplasticity contributes to the pathophysiology of schizophrenia and antipsychotics may exhibit some of their therapeutic efficacies by improving neurogenesis and/or proliferation of neural progenitors. The aim of this study is to investigate whether chronic antipsychotics treatment aff...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.09.006
更新日期:2017-12-01 00:00:00
abstract::In the present report the effects of postpuberal gonadectomy on vomeronasal organ (VO) morphology were studied. Postpuberal gonadectomy induced in both male and female rats a decrement in the height of the epithelium and in the nuclear size of the bipolar neurons. These results show that the maintenance of neurosensor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90315-8
更新日期:1984-06-01 00:00:00
abstract::Although dendritic release was first proposed in the 1970s, the mechanism of release is still subject to debate. We have used in vivo microdialysis to study the acute effects of botulinum toxin A, B and tetanus toxin injected in the substantia nigra or striatum of freely moving rats. Spontaneous and evoked dopamine re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03047-0
更新日期:2002-09-20 00:00:00
abstract::Odorant-stimulated formation of cAMP in olfactory receptor neurons may mediate olfactory signal transduction. The response is short and desensitization occurs rapidly, possibly by induction of cyclic nucleotide phosphodiesterase (PDE) activity. Previously, we showed that two low Km PDEs regulate hydrolysis of cAMP in ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91401-d
更新日期:1993-05-07 00:00:00
abstract::There have been few reports concerning facilitation and depression in sympathetic ganglia9,17,40. In the present investigation, pairs of excitatory postsynaptic potentials (EPSPs) were recorded intracellularly from bullfrog paravertebral sympathetic ganglia for an analysis of the site and mechanism responsible for the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90840-4
更新日期:1976-12-10 00:00:00
abstract::It is now well known that dopamine (DA) receptors agonists can reduce striatal DA release. These compounds are generally thought to produce short-term effects. However, in a recent in vivo study we have reported that the D1/D2 receptor agonist apomorphine might induce decrements in striatal DA release that lasted seve...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90922-9
更新日期:1994-04-11 00:00:00
abstract::NMDA receptor activation leads to elevated Ca2+ in cultured rat cortical and retinal ganglion cell neurons. If excessive, this Ca2+ response is associated with delayed neurotoxicity. We used dantrolene and ionomycin to test if the Ca2+ response to NMDA was due to mobilization of intracellular Ca2+ stores rather than m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90183-a
更新日期:1992-12-11 00:00:00
abstract::The presynaptic neurotoxin omega-conotoxin (omega-CgTx) was tested for its ability to inhibit voltage-dependent calcium flux and transmitter release in rat brain synaptosomes. Conotoxin (0.001-10 microM) had no effect on calcium uptake or endogenous dopamine release from rat striatal synaptosomes in the absence of pot...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90207-7
更新日期:1988-12-13 00:00:00
abstract::The effects of two drugs with anxiolytic actions, diazepam (0.1, 0.3 and 1 mg/kg) and nicotine (0.1 and 0.5 mg/kg) were examined on the time spent in social interaction by pairs of male gerbils. In a test arena lit by high light, diazepam (0.1 mg/kg) increased social interaction, without changing locomotor activity. D...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03102-4
更新日期:2001-01-12 00:00:00
abstract::The purpose of this study was to investigate the influence of different adenosine triphosphate (ATP) concentrations (ranging from 400 nM to 250 microM) on hippocampal potentials recorded from pyramidal neurons. ATP applied at a concentration of 400 nM induced a 100% increase in the size of the population spike (potent...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90070-x
更新日期:1989-07-10 00:00:00
abstract::In the present study, the light responses of ganglion cells to chromatic stimulus were recorded from isolated retina of neonatal chick. It was found that for some non-color-opponent ganglion cells, the spatiotemporal patterns of the cells' light responses were related to the chromatic information that they received. W...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.07.077
更新日期:2005-10-12 00:00:00
abstract::The kindling process represents a progressively augmenting electrical and behavioral response to brain stimulation, that has been proposed as a model for the development of epileptogenesis. The first experiment examined the effects of hypophysectomy on the kindling process. The effects of hypophysectomy were found to ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)91032-1
更新日期:1979-06-22 00:00:00
abstract::The present study was undertaken to disclose temporal changes in the distribution of Fos-like immunoreactive (-IR) neurons in the trigeminal subnucleus caudalis (SpVc), one of the important relay nuclei for processing the nociceptive information from the oro-facial regions, following induction of experimental tooth mo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01323-7
更新日期:1999-02-20 00:00:00
abstract::To determine the presence and distribution of cerebrovascular Abeta production we investigated amyloid beta precursor protein (AbetaPP)-mRNA expression by RNA in situ hybridization in patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type, Alzheimer disease and controls. In all subjects, AbetaPP-mRN...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01361-x
更新日期:1999-05-15 00:00:00
abstract::We monitored the protein expression profiles of collapsin response mediator protein 2 and 4 (CRMP2 and CRMP4) throughout cat primary visual area 17 at different postnatal ages. Single immunocytochemical stainings revealed a clear effect of cortical maturation on the spatial and laminar distribution profile of CRMP2 an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.03.028
更新日期:2006-05-09 00:00:00