Abstract：
:This study investigated the effects of REM (rapid eye movement) sleep deprivation (RSD) on the activity of central cholinergic receptors and passive avoidance retention in rats treated neonatally with clomipramine. Male rat pups treated with clomipramine (15 mg/kg, s.c.) twice daily from postnatal day 5 to 21 were subjected to RSD procedure at three months of age, for 4 days consecutively. In the post-RSD phase, RSD-control rats showed a significantly enhanced cholinomimetic-induced hypothermia and an improved retention in passive avoidance task. However, these measures were not significantly different in RSD-experimental group as compared to rats treated neonatally with saline. These results suggest that RSD reverses the sensitivity of central cholinergic receptors in rats given clomipramine neonatally, and this mechanism may be involved in mediating the antidepressant effects of RSD treatment in clomipramine model of depression.
journal_name
Brain Resjournal_title
Brain researchauthors
Prathiba J,Kumar KB,Karanth KSdoi
10.1016/s0006-8993(00)02248-4subject
Has Abstractpub_date
2000-06-09 00:00:00pages
243-5issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02248-4journal_volume
867pub_type
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