Abstract：
:The distribution of immunocytochemically localized subunits that comprise ionotropic non-NMDA excitatory amino acid receptors was examined in human frontal, parietal and temporal association neocortex. AMPA/kainate receptor subunits were identified using a monoclonal antibody (3A11) that recognizes an epitope common to GluR2 and GluR4 [GluR2(4)], as well as polyclonal antisera that recognize GluR2 and GluR3 (GluR2/3). Kainate receptor subunits were identified using a monoclonal antibody (4F5) that recognizes an epitope common to GluR5/6/7. For all three antibodies used, labeling was observed in a large number of neurons throughout the human association neocortex with the highest immunoreactivity present in pyramidal-like neurons, a cellular pattern largely similar to that observed in the monkey neocortex. These data demonstrate the cellular localization patterns for some non-NMDA receptor subunits in human neocortex, details upon which further studies on the roles of these subunits in human neurological diseases can be based.
journal_name
Brain Resjournal_title
Brain researchauthors
Vickers JC,Huntley GW,Hof PR,Bederson J,DeFelipe J,Morrison JHdoi
10.1016/0006-8993(94)01372-osubject
Has Abstractpub_date
1995-02-06 00:00:00pages
175-80issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(94)01372-Ojournal_volume
671pub_type
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