Abstract：
:Intake of an unconditionally preferred taste stimulus (e.g., saccharin) is reduced by contingent administration of a drug of abuse (e.g., morphine). We examined the influence of insular cortex (IC) lesions on morphine-induced suppression of an olfactory cue and two taste stimuli with different levels of perceived innate reward value. Two major findings emerged from this study. First, morphine suppressed intake of an aqueous odor as well as each taste stimulus in neurologically intact rats. Second, IC lesions disrupted morphine-induced suppression of the taste stimuli but not the aqueous odor cue. These results indicate that the perceived innate reward value of the CS is not a factor that governs drug-induced intake suppression.
journal_name
Brain Resjournal_title
Brain researchauthors
Lin JY,Roman C,Reilly Sdoi
10.1016/j.brainres.2009.07.033subject
Has Abstractpub_date
2009-10-06 00:00:00pages
52-60eissn
0006-8993issn
1872-6240pii
S0006-8993(09)01438-3journal_volume
1292pub_type
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