Abstract：
:Twice daily injections of 1.0 or 5.0 mg/kg D-amphetamine for 6 consecutive days differentially affected the response of dopaminergic neurons in the substantia nigra pars compacta to challenge injections of apomorphine on the following day. Thus, whereas treatment with the high amphetamine dose produced a dramatic shift to the right of the apomorphine dose-response curve, rats treated with 1.0 mg/kg D-amphetamine responded to apomorphine in the same way as saline-treated controls. These results support the view that long-term treatment with relatively high amphetamine doses is required to produce autoreceptor subsensitivity in the substantia nigra.
journal_name
Brain Resjournal_title
Brain researchauthors
Kamata K,Rebec GVdoi
10.1016/0006-8993(84)90691-7subject
Has Abstractpub_date
1984-10-29 00:00:00pages
147-50issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(84)90691-7journal_volume
321pub_type
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