Abstract:
:The present study using near-infrared spectroscopy (NIRS) examined prefrontal activation associated with maze-solving performance in adult humans. The participants were required to solve a plus-shaped maze, comparable to the one used for pigeons and human children to behaviorally assess planning processes, by moving a target square to a goal square presented on a touch-sensitive screen. The participants made incorrect responses toward a previous goal immediately after the goal jumped to the end of another arm, in parallel with but less frequently than previous participants, with shorter reaction times than when they correctly adjusted their responses. In these incorrect trials, relatively larger hemodynamic changes having two peaks were observed, especially in channels near the right inferior frontal cortex (IFC), suggesting use of additional cognitive resources for adjustment of responses after making errors. In addition to showing human adults' better behavioral inhibition than previous participants, the present NIRS data suggest a difference in prefrontal activation patterns according to whether inhibition of the forward plan was working well or not. The results also testify to the effective NIRS recording, while the participants were moving a computer-generated stimulus by actually making finger touches to the monitor.
journal_name
Brain Resjournal_title
Brain researchauthors
Miyata H,Watanabe S,Minagawa-Kawai Ydoi
10.1016/j.brainres.2010.12.047subject
Has Abstractpub_date
2011-02-16 00:00:00pages
90-9eissn
0006-8993issn
1872-6240pii
S0006-8993(10)02712-5journal_volume
1374pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The behavioral and physiological effects of electrical stimulation of the nucleus locus coeruleus (LC) were studied in the awake rat. LC electrodes consistently supported high rates of self-stimulation (SS). LC stimulation also inhibited spontaneous cellular discharges in the hippocampus (HPC). Both the LC-induced inh...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90140-2
更新日期:1976-05-14 00:00:00
abstract::Early brain injury (EBI) plays a pivotal role in the prognosis of patients with subarachnoid haemorrhage (SAH). Dexmedetomidine (DEX), a highly selective α2 receptor agonist, is reported to exert multiple protective effects in many neurological diseases. This study was designed to investigate whether DEX had neuroprot...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.05.040
更新日期:2018-11-01 00:00:00
abstract::Amyloid beta-protein (A beta) is the major protein of cerebrovascular and plaque amyloid in Alzheimer's disease (AD). Extensive evidence has demonstrated abnormal protein phosphorylation in this disease. We investigated the effect of synthetic A beta with the amino-acid sequence corresponding to cerebrovascular A beta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90479-7
更新日期:1993-11-26 00:00:00
abstract::The effects of midazolam, one of the most popular benzodiazepines, on synaptic transmissions were compared with intracellular recordings between CA1 pyramidal cells (CA1-PCs) and dentate gyrus granule cells (DG-GCs) in rat hippocampal slices. First, we studied the effects of midazolam on orthodromically evoked spikes,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00920-7
更新日期:1997-10-31 00:00:00
abstract::Previous studies suggested the existence of two populations of cells in the mammalian sympathetic nervous system which differ in their ability to express phenylethanolamine N-methyltransferase (PNMT), the enzyme which specifically subserves the biosynthesis of epinephrine: (1) sympathoblasts and their progeny, the nor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90163-9
更新日期:1984-04-01 00:00:00
abstract::Astaxanthin (AST) is a powerful antioxidant that occurs naturally in a wide variety of living organisms. Much experimental evidence has proved that AST has the function of eliminating oxygen free radicals and can protect organisms from oxidative damage. The present study was carried out to further investigate the neur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.09.016
更新日期:2010-11-11 00:00:00
abstract::Insulin has emerged as an important neuropeptide. Central actions of insulin appear to oppose those in the periphery. Insulin is transported across the blood-brain barrier (BBB) by a saturable transport system. The permeability of the BBB to insulin is altered by various events, but no studies exist that have examined...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03247-9
更新日期:2001-03-30 00:00:00
abstract::We have evaluated changes in the expression of neurotrophin-3 (NT-3) and its tyrosine kinase C (TrkC) receptor in the neuromuscular system as a result of voluntary physical activity. We assessed changes in the mRNAs and proteins for NT-3 and TrkC in the lumbar spinal cord and associated soleus muscle following 3 and 7...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)03258-x
更新日期:2003-10-10 00:00:00
abstract::The non-cholinergic excitatory potential elicited in neurons of the isolated inferior mesenteric ganglia was depressed by bath application of Met- or Leu-enkephalin and enhanced by naloxone or naltrexone. The membrane depolarization induced by exogenously applied putative transmitter substance P was not appreciably af...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90211-6
更新日期:1982-03-04 00:00:00
abstract::Few clinical or experimental studies have carried out systematic investigations of cutaneous and deep sensibility in areas with referred muscle pain. Therefore, no clear signs of increased or decreased psychophysical responses to various somatosensory stimuli are found in referred pain areas. In the present study, a t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01077-3
更新日期:1997-01-02 00:00:00
abstract::Adenylate cyclase activity accumulated proximal to a constriction placed around the frog sciatic nerve. The rate of accumulation was linear between 8 and 24 h following placement of the constriction; accumulation rate declined substantially after 24 h. Accumulation of activity distal to the constriction in normal nerv...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90284-0
更新日期:1982-01-28 00:00:00
abstract::This study examines projection to the cerebellar flocculus of eye movement-related neurons in the median and paramedian part of the cat pontine tegmentum between the trochlear and the abducens nucleus. They were identified by rhythmic activity related to horizontal vestibular nystagmus induced by sinusoidal rotation. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90465-5
更新日期:1980-02-10 00:00:00
abstract::Some occluded arteries of acute ischemic stroke (AIS) patients are not recanalized, even if thrombolytic therapy is performed. Considering such clinical settings, we examined the potential cerebroprotective efficacy of TAK-937, a novel cannabinoid receptor agonist, in young adult and aged rats with a permanent middle ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.06.014
更新日期:2013-08-14 00:00:00
abstract::Sleep-suppressive activity of prostaglandin synthesis inhibitors, diclofenac sodium (DF) and indomethacin (IM), was examined in unrestrained male rats. An intraperitoneal injection of 5 mg/kg IM, or an oral administration of 5 mg/kg DF and 10 mg/kg IM at an early phase of the light period transiently decreased slow wa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90173-4
更新日期:1988-06-21 00:00:00
abstract::The present study aimed to determine whether the observation of different grasps of the same object elicits automatic imitation of the kinematics of those grasps and this process influences the estimation of intrinsic target properties. In experiments 1 and 2, participants reached and grasped differently sized spheres...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.04.046
更新日期:2008-07-07 00:00:00
abstract::The participation of glutamatergic circuits of the ventral basal ganglia in feeding-related regulatory mechanisms has been extensively indicated in primate and rodent species. In avian species, it has been shown that ICV injections of MK-801 or of CNQX increase food intake and reduce the latency of feeding initiation ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04196-3
更新日期:2003-03-14 00:00:00
abstract::Febrile seizure (FS) remains the most common childhood neurological emergency. Although many studies have been done, controversy exists as to whether these seizures are associated with a significant risk for cognitive impairment. The aim of our study is to check whether there is a spatial learning and memory deficit i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.02.026
更新日期:2014-04-04 00:00:00
abstract::The effects of medial septal lesions on latent inhibition (LI) were assessed in a conditioned taste aversion paradigm. Animals were tested in a LI paradigm 2 weeks after receiving medial septal or sham lesions. The LI paradigm involved a pre-exposure phase in which water-deprived rats were allowed access to either wat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03192-9
更新日期:2001-02-02 00:00:00
abstract::Noxious stimulation of the leg increases hind limb blood flow (HBF) to the ipsilateral side and decreases to the contralateral in rat. Whether or not this asymmetrical response is due to direct control by sympathetic terminals or mediated by other factors such as local metabolism and hormones remains unclear. The aim ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.03.057
更新日期:2011-05-19 00:00:00
abstract::Spreading depression (SD) is characterized by a transient breakdown of neuronal function concomitant with a massive failure of ion homeostasis. It is a phenomenon that can be induced in neocortical tissue by raising excitability, e.g. injection of K(+), application of glutamatergic agonists, or blocking Na(+)/K(+) ATP...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02600-3
更新日期:2003-06-13 00:00:00
abstract::This study examines the preventive and therapeutic effects of curcumin on brain edema after hypoxic-ischemic brain damage (HIBD) in a rat model. Male Sprague-Dawley rats were divided into four groups: a sham group (SH), a hypoxic-ischemic group (HI) without drug treatment, a hypoxic-ischemic group (CU) with curcumin i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.07.055
更新日期:2012-09-26 00:00:00
abstract::In pentobarbitone-anesthetized cats, the spike sequences of dorsal horn neurons were recorded in response to random stimulation of branches of the suralis nerve. Combined frequency- and time-domain analysis was performed on the stimulus and spike trains. Coherence function estimates computed by spectral analysis were ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90598-7
更新日期:1988-10-11 00:00:00
abstract::The subfornical organ, along with other regions of the lamina terminalis, may contain osmoreceptors and is likely to be a site of action of blood-borne angiotensin II. The neural pathways by which these stimuli lead to vasopressin secretion, have been suggested to extend from the subfornical organ to hypothalamic site...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90708-4
更新日期:1991-08-30 00:00:00
abstract::Immunohistochemistry for three calcium-binding proteins calbindin D-28k, calretinin, and parvalbumin revealed neuronal heterogeneity within the GP. Each neurone appeared to express either a single type of calcium binding protein or none at all. The co-localisation of calcium binding proteins was not observed. Combined...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03263-2
更新日期:2002-03-08 00:00:00
abstract::Spinally-projecting A5 neurons were studied with anatomical and electrophysiological techniques in the rat. A detailed study of the number and distribution of spinally-projecting catecholaminergic (CA) and non-catecholaminergic neurons present in a defined area of ventrolateral pontine reticular formation was performe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90206-3
更新日期:1984-06-11 00:00:00
abstract::Intrathecally-administered clonidine inhibited the spontaneous firing of single neurons in the pontine nucleus locus coeruleus of rats. Such inhibition of neuron firing was not observed when the non-lipophilic alpha 2 adrenoceptor agonist (oxymetazoline) was administered intrathecally. It is concluded that lipophilic ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90752-7
更新日期:1983-10-16 00:00:00
abstract::Autoradiographic analysis of [(35)S]GTPgammaS binding was used to investigate functional activation of dopamine receptors in rat striatum. Dopamine-stimulated [(35)S]GTPgammaS binding was observed with a maximal increase of 38% over basal activity. A similar stimulatory response was obtained with the D(2) agonist quin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02981-4
更新日期:2000-12-01 00:00:00
abstract::The search for the neural substrate of a state of consciousness has led to the expectation that there may be neurons which discharge tonically and rhythmically during that state alone. We have now recorded in the cat the first evidence of neurons whose rhythmic discharge is consistent with the hypothesis of a tonicall...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90900-3
更新日期:1977-01-21 00:00:00
abstract::We examined the in vivo synthesis of brain phosphatidylcholine (PC) by the methylation of phosphatidylethanolamine (PE). [3H-methyl]methionine was infused i.c.v., by indwelling cannula, and brain samples were taken 0.5-18 h thereafter and assayed for [3H]PC, as well as for its biosynthetic intermediates [3H]phosphatid...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90576-2
更新日期:1987-09-01 00:00:00
abstract::To learn whether there are developmental changes in salt and acid taste responses from the posterior tongue, we recorded from the glossopharyngeal nerve, which innervates taste buds in circumvallate papillae, in sheep fetuses, lambs and adults. Multifiber responses to NH4Cl, KCl, NaCl, LiCl, citric and hydrochloric ac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90205-5
更新日期:1983-12-01 00:00:00