Abstract：
:Regeneration of severed hypothalamic peptidergic neurosecretory axons into the ventral pia-arachnoid was observed in rats at the light microscopic and fine-structural levels. A temporal increase occurred in the number of neurophysin-positive axons regenerating into the leptomeninges for distances up to 3.3 mm by 40 days post-lesioning. A consistent pattern of parallel, meshed and clustered axons, occurring either singly or in bundles, was present within the connective tissue, while plexus and bundles were observed in association with leptomeningeal blood vessels. Axons were characterized by preterminal and terminal dilatations. Neurosecretory granulated vesicles occurred throughout axons. The presence of microvesicles at contact points with basal lamina suggests the possibility of hormone release. Most axons were arranged as fascicles associated closely with basal lamina-bounded support cells whose thin lamellar processes wrapped single axons or fascicles of axons. We conclude, therefore, that cellular and intercellular leptomeningeal microenvironments support and sustain the growth and regeneration of transected neurosecretory axons.
journal_name
Brain Resjournal_title
Brain researchauthors
Dellmann HD,Lue LF,Bellin SI,Ouassat Mdoi
10.1016/0006-8993(88)91557-0subject
Has Abstractpub_date
1988-05-31 00:00:00pages
181-9issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(88)91557-0journal_volume
450pub_type
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