Abstract：
:Previous studies have clearly shown that the progressive decrease of growth hormone (GH) secretion occurring during ageing is coupled with a reduced responsiveness of pituitary GHRH receptors both in terms of GH secretion and activation of the adenylyl cyclase (AC), in the presence of increased basal values of the enzyme. The mechanism(s) subserving the age-associated alterations of GHRH-sensitive AC is likely related to the progressive decrease of hypothalamic GHRH function occurring with ageing. In this context, in old male rats, short-term administration of GHRH decreased the high basal AC activity and enhanced the GHRH-stimulated AC activity. Along this line, we decided to investigate whether experimentally induced abrogation of GHRH function in adult rats would induce the same alterations of AC-coupled GHRH receptors present in aged rats. Passive immunization of male young-adult rats with supra-maximal doses of GHRH antiserum (Ab-GHRH) significantly reduced the AC responsiveness to GHRH, an effect already evident 5 days post-injection and still present at 10 days. At this time interval, the treatment also evoked a significant increase of basal AC levels and of Gs alpha protein in the pituitary and completely blocked the GH-releasing effect of a bolus injection of GHRH. Furthermore, mechanical disruption of brain-pituitary links by complete stereotaxical ablation of the mediobasal hypothalamus induced a significant increase of basal AC levels and Gs alpha protein in the pituitary and a strikingly lower AC responsiveness to GHRH.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Brain Resjournal_title
Brain researchauthors
Qing Y,Parenti M,Guzzi F,Ceresoli G,Müller EE,Cocchi Ddoi
10.1016/0006-8993(94)90340-9subject
Has Abstractpub_date
1994-04-25 00:00:00pages
13-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(94)90340-9journal_volume
644pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Golgi examination of neurons of self-stimulation areas of the lateral hypothalamus and substantia nigra-ventral tegmental areas of adult Wistar rats that had experienced self-stimulation for 10 days revealed a significantly higher number of dendritic branching points in the two self-stimulation areas, and also in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91079-v
更新日期：1990-09-10 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF) is a family of neurotrophins that plays crucial roles in neural development, survival, maintenance and regeneration both in central and peripheral nervous systems. To examine the effects of BDNF on mastication, jaw movement trajectories and masticatory muscle activities were el...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.04.061
更新日期：2004-07-30 00:00:00
abstract：:Neonatal rat superior cervical ganglia were mechanically dissociated, and the sympathetic neurons grown in dispersed cell cultures. Intracellular microelectrodes were used to study the effects of tetraethylammonium (TEA+), a blocker of outward K+ currents, on the excitable properties of these neurons. Addition of TEA+...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91234-4
更新日期：1984-02-20 00:00:00
abstract：:An initial decrement followed by a significant recovery of choline acetyltransferase and acetylcholinesterase activities in the ipsilateral hippocampus was observed in rats with unilateral, partial transection of the fimbria. Regeneration of hippocampal cholinergic terminals could account for the parallel return towar...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90921-6
更新日期：1983-10-24 00:00:00
abstract：:The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01952-6
更新日期：1999-10-16 00:00:00
abstract：:The effects of estrus and prolonged estradiol benzoate (EB) treatment on estrogen receptor-like immunoreactivity (ER-LI) were studied in the female Brazilian opossum (monodelphis domestica) brain. In general, both estrus animals and EB treated animals had reduced ER-LI in specific brain regions when compared to ovarie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90632-w
更新日期：1993-07-16 00:00:00
abstract：:An isoindolin-1-one derivate, JM-1232(-), was recently developed as a sedative and hypnotic agent with a strong affinity for the central benzodiazepine binding site of gamma-aminobutyric acid(A) (GABA(A)) receptors. The purpose of this study was to examine the effects of JM-1232(-) on the cardiovascular and sympatheti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.092
更新日期：2009-12-01 00:00:00
abstract：:Previous studies have shown that pyramidal neurons in hippocampal regions CA1 and CA3 are selectively vulnerable in several neurodegenerative disorders and that a subpopulation of pyramidal neurons in cell cultures of embryonic hippocampus are sensitive to glutamate neurotoxicity. In order to determine whether the pat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90436-8
更新日期：1989-06-19 00:00:00
abstract：:The nictitating membrane response to periocular electrostimulation was investigated in anesthetized and paralyzed rabbits. Recordings from the abducens nerve, which carries the fibers innervating retractor bulbi muscles that are primarily involved in this reflex, showed two distinct volleys to effective stimulation: a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91143-5
更新日期：1983-01-10 00:00:00
abstract：:The avian pineal exhibits a daily rhythm in the synthesis and secretion of the hormone, melatonin, which is involved in maintaining temporal order within the circadian system of some species. The pineal is richly innervated by sympathetic nerves which originate in the superior cervical ganglia (SCG) and, in the chicke...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90636-n
更新日期：1992-01-13 00:00:00
abstract：:Serotonin 1A receptor (5-HT(1A)R) agonists have emerged as valuable supplements to l-DOPA therapy, demonstrating that they can decrease side effects and enhance motor function in animal models of Parkinson's disease (PD) and human PD patients. The precise mechanism by which these receptors act remains unknown and ther...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.05.005
更新日期：2007-07-16 00:00:00
abstract：:An apparent binding activity of [3H]glutathione was examined by using synaptic membrane preparations of the rat brain. The activity was found to be more than two times as high at 30 degrees C as that found at 2 degrees C. At 2 degrees C, the apparent binding sites consisted of a single component with a Kd of 0.77 micr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90524-0
更新日期：1988-10-25 00:00:00
abstract：:In the present study we investigated whether nitroflurbiprofen (NFP) or nitro-aspirin can reduce the inflammatory response induced by continuous infusion of lipopolysaccharide (LPS) into the fourth ventricular space of the rat's brain for 30 days. The chronic LPS infusion produced an extensive inflammation that was pa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01081-6
更新日期：1999-01-02 00:00:00
abstract：:Altered expression of neurotrophins may contribute to the pathogenesis of schizophrenia. Several studies suggest sex steroid hormones may be involved in the regulation of brain-derived neurotrophic factor (BDNF) signaling, as well as the symptoms of schizophrenia. This study aimed to identify sex differences in BDNF-T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.060
更新日期：2011-04-12 00:00:00
abstract：:The understanding of sarcasm reflects a complex process, which involves recognizing the beliefs of the speaker. There is a clear association between deficits in mentalizing, which is the ability to understand other people's behavior in terms of their mental state, and the understanding of sarcasm in individuals with a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.09.088
更新日期：2006-12-08 00:00:00
abstract：:The present study has shown that after intravenous injection of [125I]NGF the time-course of appearance of radioactivity in all organs studied with the exception of sympathetic and sensory ganglia, roughly paralleled that of the blood. The highest levels were reached immediately after injection, after which the radioa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90530-8
更新日期：1976-06-11 00:00:00
abstract：:In rats under urethane or pentobarbitone anesthesia, Ca2+ -sensitive microelectrodes were inserted into CA3 and CA1 hippocampal cells. In 23 neurons with a mean resting membrane potential (Vm) of -56.9 mV, the Ca potential (VCa) fell below Vm by an average of -22.1 mV (S.D. +/- 19.1 mV), indicating a mean intracellula...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90388-4
更新日期：1986-05-21 00:00:00
abstract：:The present studies examined the hypothesis that the N-methyl-D-aspartate (NMDA) receptor-nitric oxide (NO) pathway might be involved in the acute and chronic actions of delta 9-tetrahydrocannabinol (THC). The ability of dizocilpine (MK-801), a competitive NMDA receptor antagonist and NG-monomethyl-L-arginine (L-NMMA)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91715-9
更新日期：1994-12-19 00:00:00
abstract：:The stimulated (40 Hz) release of enkephalin from the myenteric plexus can be modulated by multiple types of opiate receptor. The direction of the modulation is not fixed but is bimodal. Both an inhibition and an enhancement of evoked release is observed depending on the concentration of opioid agonist that is used. E...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91594-1
更新日期：1989-12-11 00:00:00
abstract：:Early brain injury (EBI) refers to the direct injury to the brain during the first 72 h after subarachnoid hemorrhage (SAH), which is one of the major causes for the poor clinical outcome after SAH. In this study, we investigated the effect and the related mechanism of Salvinorin A (SA), a selective kappa opioid recep...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.05.026
更新日期：2019-09-15 00:00:00
abstract：:The linear nucleus (Li) is a prominent cell group in the caudal hindbrain, which was first described in a study of cerebellar afferents in the rat by [Watson, C.R.R., Switzer, R.C. III, 1978. Trigeminal projections to cerebellar tactile areas in the rat origin mainly from N. interpolaris and N. principalis. Neurosci. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.02.068
更新日期：2009-05-19 00:00:00
abstract：:Radioautography was used to study the intraneuronal distribution of [3H]-serotonin (5-HT) and/or its derivatives selectively taken up by the olfactory bulb (OB) serotonergic terminals and subsequently transported to their parent cell bodies in the midbrain raphe nuclei. This was done 24 h after injection of [3H]5-HT i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90405-9
更新日期：1980-09-08 00:00:00
abstract：:The presynaptic neurotoxin omega-conotoxin (omega-CgTx) was tested for its ability to inhibit voltage-dependent calcium flux and transmitter release in rat brain synaptosomes. Conotoxin (0.001-10 microM) had no effect on calcium uptake or endogenous dopamine release from rat striatal synaptosomes in the absence of pot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90207-7
更新日期：1988-12-13 00:00:00
abstract：:Recent studies, which have shown an increase of plasma vasopressin (VP) in experimental motion sickness and the efficacy of VP antagonists for motion sickness, suggest an important role of VP in the development of vestibulo-autonomic responses. We have recently found evidence of the co-existence of vasopressinergic ne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02799-8
更新日期：2001-09-28 00:00:00
abstract：:Histamine is one of the neurotransmitters suppressing appetite, but the interactions of histaminergic neurons with other neurons in satiety centers have not been clarified. Noradrenaline in the para-ventricular nucleus (PVN) has been shown to stimulate feeding. This study was designed to determine whether histamine mo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01339-6
更新日期：1999-05-15 00:00:00
abstract：:We examined whether there are the neurotransmitter candidate amino acid L-proline containing neurons localized in the rat brain. Antibodies against L-proline conjugated with rabbit serum albumin were raised in a rabbit and purified with affinity chromatography. Strong L-proline-like immunoreactivity was confined to se...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.12.064
更新日期：2006-02-16 00:00:00
abstract：:Following the injection of small volumes of horseradish peroxidase conjugated with wheatgerm agglutinin into the substantia nigra of the rat, a high proportion of the total neuronal population in parts of the ipsilateral neostriatum was retrogradely labelled with horseradish peroxidase. Quantitative estimates in 1-mic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91222-1
更新日期：1981-09-14 00:00:00
abstract：:Unilateral injections of 6-hydroxydopamine into the lateral hypothalamus or ventral tegmental area that damage extensively the mesotelencephalic dopaminergic projection result in significant hemispheric asymmetries in autoradiographic labeling after [14C]2-deoxy-D-glucose (2DG) administration. The incorporation of thi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90442-4
更新日期：1980-09-15 00:00:00
abstract：:Repetitive stimulation of an axon in the right visceropleural connective to the abdominal ganglion of Aplysia californica produces post-tetanic potentiation (PTP) of a unitary monosynaptic EPSP recorded from cell R15. PTP decays within one half hour following cessation of repatitive stimulation. Stimulation of the lef...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91262-7
更新日期：1980-01-06 00:00:00
abstract：:The relationship between seizure propensity and the vascular anatomy of the anterior cerebral arteries, or stroke induced by unilateral ligation of the common carotid artery, was investigated utilizing well differentiated colonies of seizure-prone (SP) and non-seizure-prone (NSP) gerbils. Twenty SP and 20 NSP gerbils ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90867-8
更新日期：1982-02-25 00:00:00
