Abstract：
:The presynaptic neurotoxin omega-conotoxin (omega-CgTx) was tested for its ability to inhibit voltage-dependent calcium flux and transmitter release in rat brain synaptosomes. Conotoxin (0.001-10 microM) had no effect on calcium uptake or endogenous dopamine release from rat striatal synaptosomes in the absence of potassium depolarization. Fast-phase potassium stimulated calcium influx was only partially (20-30%) inhibited by conotoxin at concentrations between 1 nM and 10 microM. The fast-phase release of endogenous dopamine from the same synaptosomal preparation was inhibited by approximately 25% at 0.01 microM and by 60% at 10 microM. These results suggest that a subgroup of high affinity omega-CgTx-sensitive calcium channels may be involved in regulating the release of endogenous dopamine from brain synaptosomes.
journal_name
Brain Resjournal_title
Brain researchauthors
Woodward JJ,Rezazadeh SM,Leslie SWdoi
10.1016/0006-8993(88)90207-7subject
Has Abstractpub_date
1988-12-13 00:00:00pages
141-5issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(88)90207-7journal_volume
475pub_type
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