Abstract：
:The influence of the inhibitory transmitter gamma-aminobutyric acid (GABA) on depolarizations elicited by the excitatory amino acid N-methyl-D-aspartate (NMDA) was tested in neurons of organotypic neocortical tissue cultures (newborn rat) and in CA3 neurons of the hippocampal slice (guinea pig). Drugs were applied through a 3-barrelled micropipette by pressure ejection. Applications of GABA before the ejection of NMDA increased the amplitude of the depolarizations induced by the excitatory amino acid. It is suggested that the enhancement of NMDA responses by GABA may be mainly mediated by an intracellular common pathway.
journal_name
Brain Resjournal_title
Brain researchauthors
Walden J,Speckmann EJ,Bingmann D,Straub Hdoi
10.1016/0006-8993(90)90737-vsubject
Has Abstractpub_date
1990-02-26 00:00:00pages
127-9issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(90)90737-Vjournal_volume
510pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:A procedure has been developed for the stable long-term recording of nerve signals in unanesthetized mammals, which should have wide application in basic research on the nervous system and also in clinical areas such as the derivation of control signals for powered prostheses. Methods are fully described for construct...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90233-5
更新日期：1977-06-03 00:00:00
abstract：:Chronic peripheral inflammation or peripheral neurectomy cause changes in GABA levels and GABA immunoreactivity in the spinal cord dorsal horn. The present study aimed to investigate if such changes are accompanied by alterations in GABA receptor binding. Neurectomy of the sciatic nerve caused an ipsilateral down-regu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00262-o
更新日期：1995-05-15 00:00:00
abstract：:Iontophoresis of baclofen produced hyperpolarization and a decrease in input resistance in 32 neurons and no effect in 24 neurons of the ventral respiratory group in cats. Iontophoresed phaclofen antagonized the effect of baclofen, but had negligible effects on periodic fluctuations in membrane potential and spike act...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90832-8
更新日期：1993-09-17 00:00:00
abstract：:Regulation of tyrosine hydroxylase (TH) by second messenger pathway activators was examined in rat olfactory bulb cell cultures. The number of TH-immunoreactive neurons was increased 2-3-fold by 36 h treatments with forskolin (Fsk, 10(-6) M) or phorbol myristate acetate (PMA, 10(-7) M), but was not significantly incre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(09)90015-4
更新日期：1994-09-26 00:00:00
abstract：:The role of cat's primary auditory cortex (AI) in both pattern discrimination and sound localization has been demonstrated by observing that ablations of it disrupt these functions. This research studied effective connectivity variations as a function of modifications in the temporal pattern of acoustic stimulation. R...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91542-9
更新日期：1988-05-31 00:00:00
abstract：:Cocaine increases dopamine concentration in the nucleus accumbens through competitive binding to the dopamine transporter (DAT). However, it also increases the frequency of dopamine release events, a finding that cannot be explained by action at the DAT alone. Rather, this effect may be mediated by cocaine-induced mod...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.10.022
更新日期：2017-01-15 00:00:00
abstract：:Extracellular recordings from the supraoptic nucleus of the rat established that vasopressinergic neurosecretory cells were excited by stimulation of cervical but not abdominal vagal afferents. This response was absent or significantly attenuated after microinjection of gamma-aminobutyric acid into a region of the cau...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91131-w
更新日期：1992-10-30 00:00:00
abstract：:The duration of the sensitive period of the kitten visual cortex to the effects of monocular deprivation was explored by studies of the behavioral and physiological recovery from extended periods of monocular occlusion imposed from birth, and by examination of the physiological effects of a 3 month period of monocular...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91303-7
更新日期：1980-06-09 00:00:00
abstract：:The biosynthetic activity of extra-hypothalamic vasopressin (VP) neurons in the bed nucleus of the stria terminalis (BNST) is regulated by gonadal steroids. These neurons have also been implicated in a number of behaviors that are impaired in aging. We previously reported that VP mRNA labelling in the BNST is decrease...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(10)80030-7
更新日期：1992-06-26 00:00:00
abstract：:The present experiments showed that there is a cortico-thalamo-cortical projection system in the cat, which originates from the primary visual cortex, relayed by the lateral part of the lateral posterior nucleus of the thalamus, and reaching the medial bank of the lateral suprasylvian visual area. This finding suggest...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90323-4
更新日期：1990-02-12 00:00:00
abstract：:C57BL/6J (B6) and DBA/2J (D2) mice have been characterized previously as seizure-resistant and seizure-sensitive, respectively, a distinction based primarily upon a differential response to the convulsant effects of various drugs. In the present study, electroconvulsive shock (ECS) was used to assess maximal electrosh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01013-0
更新日期：1998-11-30 00:00:00
abstract：:The effect of high concentrations of L-ascorbic acid on the in vivo and in vitro growth of human neuroblastoma has been investigated. Directly implemented into cell culture it decreased the DNA, RNA and protein synthesis, and mitosis of neuroblastoma cells, without affecting normal neuronal cells. In vivo treatment of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91139-4
更新日期：1985-09-09 00:00:00
abstract：:Electrophysiological studies on the entopedunculo- and cerebello-thalamic projections were performed by intracellular recordings in the thalamic VA, VL and VM nuclei of cats under sodium pentobarbital anesthesia. Identification of the thalamic neurons were performed electrophysiologically by antidromic activation on s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91091-6
更新日期：1984-06-03 00:00:00
abstract：:Previous studies have shown that steroid receptor coactivator-1 (SRC-1) is involved in the regulation of Purkinje cell development and motor learning, neural stem cell differentiation and reproductive-related plasticity. It is widely distributed in the adult brain, but the aging-related changes in the brain remain unc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.024
更新日期：2011-03-25 00:00:00
abstract：:Inflammatory reactions occurring in the brain after ischemia may contribute to secondary damage. In the present study effects of minocycline, an anti-inflammatory agent, alone or in combination with mild hypothermia, on focal embolic brain ischemia have been examined. Focal ischemic injury was induced by embolizing a ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04045-3
更新日期：2003-02-14 00:00:00
abstract：:Using fMRI, cerebral activations were studied in 24 classically-trained keyboard performers and 12 musically unskilled control subjects. Two groups of musicians were recruited: improvising (n=12) and score-dependent (non-improvising) musicians (n=12). While listening to both familiar and unfamiliar music, subjects eit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.06.050
更新日期：2015-10-22 00:00:00
abstract：:The effect of different steady-state cocaine concentration maintenance on the microdialysis extraction fraction of cocaine (in situ recovery; Ed) in the medial prefrontal cortex (mPFC) was examined. Male, adult Sprague-Dawley rats anesthetized with chloral hydrate were used. All rats were randomly divided into three g...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00456-z
更新日期：1995-07-24 00:00:00
abstract：:In the present study, the role of medial septal receptors in behaviour-induced increase in acetylcholine (ACh) release in hippocampus was investigated using dual-probe microdialysis in combination with a simple behavioural procedure. gamma-Aminobutyric acid (GABA) and glutamate receptor agonists and antagonists were a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01445-5
更新日期：1998-04-06 00:00:00
abstract：:Increases in concentration of brain NO are proposed to initiate and mediate migraine headache. Triggered by focal depolarisation, spreading depression (SD) represents a suitable mechanism for eliciting widespread release of nitric oxide. The current study examines the effect of sumatriptan, a 5-HT(1B/1D) agonist and e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02400-8
更新日期：2000-07-07 00:00:00
abstract：:Evidence exists that repeated injections of melatonin in rather large doses inhibit sexual performance in male rats. In contrast, systemic injection of small doses of this hormone stimulates sexual activity of normal male rats. In these experiments, systemic acute administration of melatonin in small doses (10-100 mic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02715-3
更新日期：2000-09-29 00:00:00
abstract：:Increased permeability of the brain-blood barrier (BBB) in the piriform cortex (PC) has been reported in various animal models of temporal lobe epilepsy. Since BBB disruption induced by epileptogenic insult has not fully clarified, we attempted to determine whether changes in BBB-related molecules are associated with ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.10.080
更新日期：2011-01-19 00:00:00
abstract：:The effect of a single subcutaneous (s.c.) injection of the ultrapotent capsaicin analogue resiniferatoxin (RTX) on responses of adult rats to noxious thermal and mechanical stimulation was examined. The effects of RTX treatment on the nociceptive flexor reflex and activity-dependent increase in spinal excitability af...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01444-8
更新日期：1997-03-28 00:00:00
abstract：:The present experiments were performed to demonstrate in vivo the existence of a modulatory role of Na+ in the inhibitory control of prolactin (PRL) secretion. Groups of adult male rats were either adrenalectomized (adrenex) or sham-operated (normals) and implanted in the right atrium with a chronic cannula for the in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91158-9
更新日期：1987-01-13 00:00:00
abstract：:Single unit activities of Y, X and W cells were recorded in the cat lateral geniculate nucleus to study how their responses to stationary light spots change with the cortical EEG. The shift from desynchronized to synchronized EEG drastically suppressed W cell activities, depressed both transient and sustained componen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90102-3
更新日期：1988-07-12 00:00:00
abstract：:Cortical sensory neurons synchronize their activity at multiple frequency bands after an external stimulation. In the somatosensory cortical areas, previous reports describe more discrete and somatotopically specific neural synchronization at the gamma band. Therefore, an efficient gamma synchronization of the neurons...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03171-8
更新日期：2003-10-03 00:00:00
abstract：:The response of granule cells and CA1 pyramidal neurones to NMDA was studied in the presence and absence of Mg2+ using an in vitro slice preparation. In the absence of Mg2+ the depolarizing response of hippocampal neurones to NMDA is accompanied by a decrease in input resistance. In the presence of Mg2+ ions, however,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90107-0
更新日期：1984-10-08 00:00:00
abstract：:The human neostriatum was found to contain large neurons (maximum diameter: 30-40 microns) that stain intensely for acetylcholinesterase (AChE). These neurons are few in number, representing less than 5% of the total striatal neuronal population, and appear uniformly scattered throughout the caudate nucleus and putame...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90663-2
更新日期：1984-01-16 00:00:00
abstract：:Binding of [125I]-labeled Bolton-Hunter substance P ([125I]-BHSP) to NK1 receptors was investigated in the spinal cord of young (3-4 month) and aged (14-16 month) rats. In homogenates of whole spinal cord, the affinity (equilibrium dissociation constant, approximately 210 pM) and maximum density of [125I]-BHSP binding...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01463-7
更新日期：1998-03-09 00:00:00
abstract：:In this report we have described several aspects of glial development in cultures containing dissociated DRG neurons and glial cells obtained from dissociated spinal cord at least a week prior to the onset of in vivo myelination. With time in culture the dissociated neurons and glia interact and become organized into ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90045-2
更新日期：1984-02-01 00:00:00
abstract：:The insular cortex (IC) has been reported to modulate the cardiac parasympathetic activity of the baroreflex in unanesthetized rats. However, which neurotransmitters are involved in this modulation is still unclear. In the present study, we evaluated the possible involvement of local IC-noradrenergic neurotransmission...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.013
更新日期：2009-10-27 00:00:00
