Complex changes of GABAA and GABAB receptor binding in the spinal cord dorsal horn following peripheral inflammation or neurectomy.

Abstract:

:Chronic peripheral inflammation or peripheral neurectomy cause changes in GABA levels and GABA immunoreactivity in the spinal cord dorsal horn. The present study aimed to investigate if such changes are accompanied by alterations in GABA receptor binding. Neurectomy of the sciatic nerve caused an ipsilateral down-regulation of GABAB receptor binding in lamina II of the spinal cord 2-4 weeks after the nerve injury. Since approximately 50% of GABAB receptor binding in that region is located on primary afferent endings, degenerative changes of such endings caused by the nerve lesion can explain the observed reduction. In contrast, GABAA binding was substantially enhanced following neurectomy, which may be due to an up-regulation of the receptors issued by the concomitant decrease of endogenous GABA. In rats bearing unilateral chronic peripheral inflammation induced by intraarticular injection of complete Freund's adjuvant we found a reduction of GABAB binding in the superficial dorsal horn. This effect, which was maximal at 3-4 weeks after adjuvant injection, was attributed to an enhanced release of GABA by spinal interneurons. GABAA receptor binding was not changed in this experimental model. Together, these results suggest that the two receptor types may be located at different loci and are differently affected by variations in sensory input.

journal_name

Brain Res

journal_title

Brain research

authors

Castro-Lopes JM,Malcangio M,Pan BH,Bowery NG

doi

10.1016/0006-8993(95)00262-o

subject

Has Abstract

pub_date

1995-05-15 00:00:00

pages

289-97

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(95)00262-O

journal_volume

679

pub_type

杂志文章
  • Ischemia-induced changes of platelet endothelial cell adhesion molecule-1 in the hippocampal CA1 region in gerbils.

    abstract::We observed chronological changes of platelet endothelial cell adhesion molecule-1 (PECAM-1), final mediator of neutrophil transendothelial migration, immunoreactivity, and protein level in the gerbil hippocampus proper after 5 min of transient ischemia. One day after ischemic insult, PECAM-1 immunoreactivity and prot...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.04.049

    authors: Hwang IK,Kim DW,Yoo KY,Jung BK,Song JH,Jung JY,Choi SY,Kang TC,Lee JY,Kwon YG,Won MH

    更新日期:2005-06-28 00:00:00

  • Macular input to neurons of the spinoreticulocerebellar pathway.

    abstract::The present report summarizes the results obtained in previous experiments in which the responses to lateral tilt of both reticulocerebellar neurons located in the lateral reticular nucleus (NRL) and ascending spinoreticular tract axons, located in the lateral funiculi of the cervical segments C2-C3, had been recorded...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(75)90112-2

    authors: Pompeiano O

    更新日期:1975-09-23 00:00:00

  • Intracellular recordings from serotonergic dorsal raphe neurons: pacemaker potentials and the effect of LSD.

    abstract::Intracellular recordings in vivo from serotonergic dorsal raphe neurons of the rat brain reveal that these cells undergo a pronounced postspike hyperpolarization followed by a gradual interspike depolarization leading to the succeeding spike. Such repetitive cycles of interspike hyperpolarization and depolarization, w...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90124-x

    authors: Aghajanian GK,Vandermaelen CP

    更新日期:1982-04-29 00:00:00

  • Unit activity of amygdala and hippocampal neurons: effects of morphine and benzodiazepines.

    abstract::The effects of morphine sulfate and two benzodiazepine derivatives, chlordiazepoxide HCl and diazepam, were evaluated upon single unit activity of the amygdaloid nuclear complex and hippocampal formation in immobilized cats. All surgical procedures were performed under halothane anesthesia and all wound margins were i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(77)90595-9

    authors: Chou DT,Wang SC

    更新日期:1977-05-13 00:00:00

  • Regenerated hair cells exhibit a transient resistance to aminoglycoside toxicity.

    abstract::Recent studies have demonstrated that sensory hair cells in the avian inner ear are reproduced by cell proliferation in response to the death of the original hair cell population. The regenerated hair cells appear to construct functional synaptic contacts, thereby transmitting acoustic signals to the peripheral nervou...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)01467-5

    authors: Hashino E,Salvi RJ

    更新日期:1996-05-13 00:00:00

  • Anterograde axoplasmic transport of peroxidase in the rat visual system after intraocular neurotoxin injection.

    abstract::The effect of intraocular injection of the neurotoxin, kainic acid, on the retinofugal pathway has been examined by anterograde transport of horseradish peroxidase. Although less peroxidase was present in all the primary optic centers after the intraocular injection of kainic acid than in the controls, the area occupi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90939-9

    authors: Gomez-Ramos P,Perez-Rico C,Reinoso-Suarez F

    更新日期:1984-01-09 00:00:00

  • Short internodal lengths of canine tooth pulp axons in the young adult cat.

    abstract::Light-microscopical measurements have been made on teased pulpal nerve fibers from young adult cat canine teeth. In the root canal portion (apical to first branching point) the mean internodal length was approximately 250 micron. In the pulpal chamber portion (coronal to the first branching point) the pulpal nerve fib...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90221-x

    authors: Fried K,Erdélyi G

    更新日期:1984-06-11 00:00:00

  • Modulation of hypoxic depressions of ventilatory activity in the newborn piglet by mesencephalic mechanisms.

    abstract::In neonates, ventilatory responses to hypoxia are 'biphasic,' with an augmentation followed by a decline. The hypoxia-induced augmentations in ventilation are attenuated and the depressions are accentuated following denervation of the peripheral chemoreceptors. Piglets that were decerebrated at a rostral mesencephalic...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)01310-9

    authors: St-John WM,St Jacques R,Li A,Darnall RA

    更新日期:1999-02-20 00:00:00

  • Prefrontal cortical dopamine depletion enhances the responsiveness of mesolimbic dopamine neurons to stress.

    abstract::Mild footshock stress results in the metabolic activation of the prefrontal cortical dopamine (DA) innervation, but does not augment DA utilization in mesolimbic areas (such as the nucleus accumbens septi, NAS) or the striatum. However, increases in either the intensity or duration of footshock stress increase DA util...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91557-w

    authors: Deutch AY,Clark WA,Roth RH

    更新日期:1990-06-25 00:00:00

  • Cerebellar cortical lesions and reacquisition in classical conditioning of the nictitating membrane response in rabbits.

    abstract::Portions of cerebellar cortex, particularly Larsell's hemisphere VI, have been identified as involved but not essential for the acquisition and retention of classical conditioning of the nictitating membrane (NM) response in rabbit. The present experiment was undertaken to examine the effect of lesions of cerebellar c...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90775-i

    authors: Woodruff-Pak DS,Lavond DG,Logan CG,Steinmetz JE,Thompson RF

    更新日期:1993-04-09 00:00:00

  • WITHDRAWN: Pax genes during neural development and their potential role in neuroregeneration.

    abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2011.05.012

    authors: Thompson JA,Ziman M

    更新日期:2011-05-12 00:00:00

  • Collateralization and GAD immunoreactivity of descending pallidal efferents.

    abstract::The first phase of this study involves injecting a different fluorescent retrograde axonal tracer into the subthalamic nucleus, the substantia nigra, and the mesopontine tegmentum. Multiple labeled cells are found within the caudal third of the globus pallidus. The entopeduncular nucleus and adjacent basal forebrain s...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90948-7

    authors: Schmued L,Phermsangngam P,Lee H,Thio S,Chen E,Truong P,Colton E,Fallon J

    更新日期:1989-05-15 00:00:00

  • Dopamine protects cerebral autoregulation and prevents hippocampal necrosis after traumatic brain injury via block of ERK MAPK in juvenile pigs.

    abstract::Traumatic brain injury (TBI) contributes to morbidity in children, and more boys experience TBI. Cerebral autoregulation is impaired after TBI, contributing to poor outcome. Cerebral Perfusion Pressure (CPP) is often normalized by use of vasoactive agents to increase mean arterial pressure (MAP). In prior studies of n...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2017.06.010

    authors: Curvello V,Hekierski H,Pastor P,Vavilala MS,Armstead WM

    更新日期:2017-09-01 00:00:00

  • Characterization of mineralocorticoid and glucocorticoid receptors in primate brain.

    abstract::Characteristics of neural corticosteroid receptors were studied in 51 adrenally-intact macaque monkeys using a modification of a corticosteroid receptor assay developed in this laboratory for rodent studies. Using cortisol as a ligand, two receptor subtypes could be distinguished and with similar Kd's to those observe...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91249-1

    authors: Brooke SM,de Haas-Johnson AM,Kaplan JR,Sapolsky RM

    更新日期:1994-02-21 00:00:00

  • Calretinin and calbindin D-28k, but not parvalbumin protect against glutamate-induced delayed excitotoxicity in transfected N18-RE 105 neuroblastoma-retina hybrid cells.

    abstract::Excitotoxic effects leading to neuronal cell degeneration are often accompanied by a prolonged increase in the intracellular level of Ca(2+) ions and L-glutamate-induced toxicity is assumed to be mediated via a Ca(2+)-dependent mechanism. Due to their buffering properties, EF-hand Ca(2+)-binding proteins (CaBPs) can a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)02753-1

    authors: D'Orlando C,Celio MR,Schwaller B

    更新日期:2002-08-02 00:00:00

  • Effect of hyperbaric oxygenation on intracranial pressure elevation rate in rats during the early phase of severe traumatic brain injury.

    abstract::Intracranial pressure (ICP) was monitored to evaluate the therapeutic effect of hyperbaric oxygen (HBO(2)) treatment following traumatic brain injury (TBI). This subject is controversial. The aim of our study was to determine whether HBO(2) treatment has a therapeutic effect on ICP dynamics and survival following seve...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.02.049

    authors: Rogatsky GG,Kamenir Y,Mayevsky A

    更新日期:2005-06-21 00:00:00

  • Effects of methyl-beta-cyclodextrin on blood-brain barrier permeability in angiotensin II-induced hypertensive rats.

    abstract::The blood-brain barrier (BBB) permeability primarily increases in cerebral venules during acute hypertension. Methyl-β-cyclodextrin (MβCD), a cholesterol-depleting agent, decreases the expression of caveolins disrupting caveolar structures. We aimed to determine the effects of MβCD on the BBB permeability of angiotens...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2019.03.024

    authors: Atış M,Akcan U,Uğur Yılmaz C,Orhan N,Düzgün P,Deniz Ceylan U,Arıcan N,Karahüseyinoğlu S,Nur Şahin G,Ahıshalı B,Kaya M

    更新日期:2019-07-15 00:00:00

  • Increases in ribosomal RNA within the denervated neuropil of the dentate gyrus during reinnervation: evaluation by in situ hybridization using DNA probes complementary to ribosomal RNA.

    abstract::Previous studies have revealed that there are increases in the incorporation of [3H]amino acids into protein in the denervated neuropil of the dentate gyrus during periods of reactive synaptogenesis. The present study evaluates whether the increase in incorporation reflects an increase in protein synthetic machinery (...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0169-328x(87)90032-5

    authors: Phillips LL,Nostrandt SJ,Chikaraishi DM,Steward O

    更新日期:1987-09-01 00:00:00

  • A deeper reanalysis of a superficial feature: an ERP study on agreement violations.

    abstract::A morphosyntactic agreement violation during reading elicits a well-documented biphasic ERP pattern (LAN+P600). The cognitive variables that affect both the amplitude of the two components and the topography of the anterior negativity are still debated. We studied the ERP correlates of the violation of a specific agre...

    journal_title:Brain research

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.brainres.2008.06.064

    authors: Molinaro N,Vespignani F,Job R

    更新日期:2008-09-04 00:00:00

  • Neuronal correlates to consciousness. The "Hall of Mirrors" metaphor describing consciousness as an epiphenomenon of multiple dynamic mosaics of cortical functional modules.

    abstract::Humans share the common intuition of a self that has access to an inner 'theater of mind' (Baars, 2003). The problem is how this internal theater is formed. Moving from Cook's view (Cook, 2008), we propose that the 'sentience' present in single excitable cells is integrated into units of neurons and glial cells transi...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainres.2012.01.003

    authors: Agnati LF,Guidolin D,Cortelli P,Genedani S,Cela-Conde C,Fuxe K

    更新日期:2012-10-02 00:00:00

  • The development of the dorsal root potential and the responsiveness of primary afferent fibers to gamma-aminobutyric acid in the spinal cord of rat fetuses.

    abstract::The development of the dorsal root potential (DRP) and the responsiveness of primary afferent fibers to gamma-aminobutyric acid (GABA) were investigated in the isolated spinal cord of rat fetuses. At embryonic day 15.5, stimulation of the lumbar dorsal root was first effective in eliciting the DRP, which was not inhib...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(85)90127-0

    authors: Seno N,Saito K

    更新日期:1985-01-01 00:00:00

  • Effect of LPS on the permeability of the blood-brain barrier to insulin.

    abstract::Insulin has emerged as an important neuropeptide. Central actions of insulin appear to oppose those in the periphery. Insulin is transported across the blood-brain barrier (BBB) by a saturable transport system. The permeability of the BBB to insulin is altered by various events, but no studies exist that have examined...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)03247-9

    authors: Xaio H,Banks WA,Niehoff ML,Morley JE

    更新日期:2001-03-30 00:00:00

  • Reserpine attenuates D-amphetamine and MDMA-induced transmitter release in vivo: a consideration of dose, core temperature and dopamine synthesis.

    abstract::Amphetamine releases dopamine through a transporter-mediated mechanism. The purpose of this report was to further our understanding of the intracellular pool from which amphetamine releases dopamine: the cytoplasmic pool, the vesicular pool, or both. Rats were treated with D-amphetamine (AMPH) (1.0 or 10.0 mg/kg) or a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00720-3

    authors: Sabol KE,Seiden LS

    更新日期:1998-09-21 00:00:00

  • Quantitative studies on proliferative changes of reactive astrocytes in mouse cerebral cortex.

    abstract::Cell number and proliferation of reactive astrocytes were studied quantitatively in the stabbed cerebral cortex of adult mice, using immunohistochemistry for glial fibrillary acidic protein (GFAP) and [3H]thymidine autoradiography. GFAP-positive astrocytes increased in cell number gradually from 24 to 96 h after stabb...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90757-3

    authors: Miyake T,Hattori T,Fukuda M,Kitamura T,Fujita S

    更新日期:1988-06-07 00:00:00

  • Excitotoxicity induced by kainic acid provokes glycogen synthase kinase-3 truncation in the hippocampus.

    abstract::In neuronal cultures, glycogen synthase kinase 3(GSK3) is truncated at the N-terminal end by calpain downstream of activated glutamate receptors. However, the in vivo biological significance of that truncation has not been explored. In an attempt to elucidate if GSK3 truncation has a pathophysiological relevance, we h...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.03.016

    authors: Jurado-Arjona J,Goñi-Oliver P,Rodríguez-Prada L,Engel T,Henshall DC,Ávila J,Hernández F

    更新日期:2015-06-22 00:00:00

  • Furosemide- and bumetanide-sensitive ion transport and volume control in primary astrocyte cultures from rat brain.

    abstract::K+ and Cl- transport using 42K+ and 36Cl- was studied in primary astrocyte cultures prepared from neonatal rat brains. A component of 42K+ uptake was sensitive to both furosemide and bumetanide with maximum inhibition being obtained at 1 and 0.01 mM concentrations of the inhibitors, respectively. Furosemide and bumeta...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91282-x

    authors: Kimelberg HK,Frangakis MV

    更新日期:1985-12-30 00:00:00

  • Topography of cholinergic perikarya and nerve fibres as well as cholinergic vesicles in the rat duodenum.

    abstract::Using the acetylthiocholine staining method, it was possible to visualize acetylcholinesterase (AChE)-stained neuronal cell bodies and nerve endings as well as AChE-positive vesicles in the rat duodenum. AChE-reactive perikarya were seen with certainty only in the myenteric plexus. They were 40 micron in diameter and ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90100-3

    authors: Wolter HJ

    更新日期:1985-07-29 00:00:00

  • Intraparenchymal fetal striatal transplants and recovery in kainic acid lesioned rats.

    abstract::Striatal kainic acid (KA) lesions induce behavioral and biochemical deficits which resemble symptoms encountered in patients suffering from Huntington's disease. In rats with KA lesions, fetal striatal transplants have shown to reverse the pervasive nocturnal hyperactivity induced by the lesion. In the present study 4...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)91313-3

    authors: Giordano M,Hagenmeyer-Houser SH,Sanberg PR

    更新日期:1988-04-12 00:00:00

  • A quantitative electron microscopic study on synapse formation in dissociated fetal rat cerebral cortex in vitro.

    abstract::Occipital cortex of 19-day-old fetal rats was dissociated and cultured in vitro for 2-5 weeks in horse serum supplemented Eagle's MEM. The outgrowing neurons rapidly formed a dense network which started to degenerate after 3 weeks in vitro. By means of electron microscopy the numerical development of 6 different categ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(81)90011-0

    authors: Romijn HJ,Mud MT,Habets AM,Wolters PS

    更新日期:1981-07-01 00:00:00

  • Changes in the immunoreactivities of an opioid peptide leumorphin in the hypothalamus and anterior pituitary during the estrous cycle of the rat and their relation to sexual behavior.

    abstract::Leumorphin, an opioid peptide whose functions are unknown, is found in mammalian brain and pituitary and stimulates lordosis behavior in estrogen-treated female rats. To elucidate the role of leumorphin in the physiological control of female sexual behavior, the levels of immunoreactive (ir) leumorphin as well as ir d...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)90417-8

    authors: Suda M,Nakao K,Sakamoto M,Morii N,Sugawara A,Imura H

    更新日期:1986-05-28 00:00:00