Abstract：
:Binding of [125I]-labeled Bolton-Hunter substance P ([125I]-BHSP) to NK1 receptors was investigated in the spinal cord of young (3-4 month) and aged (14-16 month) rats. In homogenates of whole spinal cord, the affinity (equilibrium dissociation constant, approximately 210 pM) and maximum density of [125I]-BHSP binding sites ( approximately 0.25 fmol/mg wet weight) were similar for young and aged rats. Autoradiographic studies revealed a similar distribution of [125I]-BHSP sites in both young and old rats at all spinal levels. Intense binding was observed in the superficial dorsal horn (laminae I-III), grey commissure (lamina X) and thoracic intermediolateral cell column (IML) with lower levels of binding in the deeper dorsal horn (laminae IV-VI) and ventral horn (laminae VII-IX). However, the density of [125I]-BHSP sites was significantly (P<0.05) lower in lamina X of lumbar sections of aged rats compared with young controls. These studies suggest that ageing is associated with a selective loss of NK1 receptors in lamina X of the lumbar spinal cord, although the affinity of NK1 receptors in aged rats is unchanged.
journal_name
Brain Resjournal_title
Brain researchauthors
Maguire CM,Geraghty DPdoi
10.1016/s0006-8993(97)01463-7subject
Has Abstractpub_date
1998-03-09 00:00:00pages
263-6issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(97)01463-7journal_volume
786pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The projections to the striatum from two cytoarchitectonically and functionally distinct subdivisions of the cat precruciate motor cortex were studied using anatomical and electrophysiological techniques. Our results indicate that the medial precruciate cortex (stimulation of which leads to movements of the axial and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90960-0
更新日期：1979-07-20 00:00:00
abstract：:This article has been removed, consistent with Elsevier Policy on Article Withdrawal. Please see (http://www.elsevier.com/locate/withdrawalpolicy). The Publisher apologizes for any inconvenience this may cause. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.003
更新日期：2009-10-14 00:00:00
abstract：:Fast cyclic voltammetry (FCV) at carbon fibre microelectrodes was used to monitor stimulated noradrenaline (NA) efflux in slices of the ventral part of the rat bed nucleus of stria terminalis (BSTV) superfused with artificial cerebrospinal fluid at 32 degrees C. NA efflux was evoked by local electrical stimulation (tr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91498-h
更新日期：1993-04-02 00:00:00
abstract：:Albino rats received 10 s of sub-seizure electrical stimulation applied to the dentate gyrus granule cells immediately after acquisition of information on trial 1 of a 2-trial radial maze spatial memory task. Granule cell stimulation selectively reduced the probability of accessing information held in declarative memo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90166-5
更新日期：1984-09-24 00:00:00
abstract：:We characterized acute intracerebral hemorrhage (ICH) in the rat by sequential magnetic resonance imaging (MRI) and correlated MRI findings with neurobehavior and histopathology. In addition, we investigated whether albumin treatment would reduce ICH-induced brain injury. ICH was produced in rats by a double-injection...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.077
更新日期：2007-07-09 00:00:00
abstract：:Central activation of excitatory amino acid receptors has been implicated in neuropathic pain following nerve injury. In a rat model of painful peripheral mononeuropathy, we compared the effects of non-competitive NMDA receptor antagonists (MK 801 and HA966) and a non-NMDA receptor antagonist (CNQX) on induction and m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90193-d
更新日期：1992-12-11 00:00:00
abstract：:Hydrocephalus with aqueduct stenosis was a consistent feature in mice which received a single intraperitoneal injection of 6-aminonicotinamide (6-AN) on day 5 postnatal. Chronological investigation revealed that 6-AN-treated mice had aqueductal obstruction with edematously swollen ependymal cells and spongy changes in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90180-4
更新日期：1985-10-01 00:00:00
abstract：:We used double staining immunocytochemical techniques to determine whether nitric oxide (NO) and Fos immunoreactivity induced by noxious visceral stimulation were colocalized in the neurons of the supraspinal areas. We observed a considerable increase in Fos-positive neurons in many brain areas after noxious stimulati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01434-1
更新日期：1999-07-10 00:00:00
abstract：:Fetal mouse retinal ganglion cell axons have been shown to ramify within co-cultured basement membrane secreting tumor explants and upon isolated basement membranes. Here we report that laminin, a glycoprotein found in basement membranes and adhesion sites of a variety of cell types, acted as a substrate for retinal e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90184-6
更新日期：1984-01-01 00:00:00
abstract：:This study examined the hypothesis that the subfornical organ (SFO), a circumventricular organ with both osmosensitive elements and dipsogenic receptors for circulating angiotensin (ANG) II, is important for the water drinking response that follows an intragastric (ig) load of hypertonic NaCl. A 2-ml saline load was a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00249-2
更新日期：1998-06-08 00:00:00
abstract：:To test the hypothesis that enkephalins, substance P, bradykinin and angiotensin II could act as neurohumoral modulators of hypothalamic function, these peptides (0.01-20 microgram) were injected into the general circulation of anesthetized rats, and changes in hypothalamo-neurohypophysial activity were determined by ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90214-6
更新日期：1981-09-07 00:00:00
abstract：:Extracellular recordings from the supraoptic nucleus of the rat established that vasopressinergic neurosecretory cells were excited by stimulation of cervical but not abdominal vagal afferents. This response was absent or significantly attenuated after microinjection of gamma-aminobutyric acid into a region of the cau...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91131-w
更新日期：1992-10-30 00:00:00
abstract：:This report deals with the effect of substance P (SP) and capsaicin on blood pressure and heart rate after administration into different sites of the nucleus tractus solitarii (NTS) of urethane-anesthetized rats. Microinjection of SP at 6 different coordinates throughout the NTS showed 3 sites where SP administration ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90938-3
更新日期：1987-10-06 00:00:00
abstract：:The effects of morphine sulfate and two benzodiazepine derivatives, chlordiazepoxide HCl and diazepam, were evaluated upon single unit activity of the amygdaloid nuclear complex and hippocampal formation in immobilized cats. All surgical procedures were performed under halothane anesthesia and all wound margins were i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90595-9
更新日期：1977-05-13 00:00:00
abstract：:Our research group recently presented the distribution of thyrotropin-releasing hormone (TRH) in the chicken brain. In this study we measured somatostatin (SRIH) concentrations in different brain parts and nuclei. The distribution of SRIH and TRH in peripheral tissues was also studied. Although the highest SRIH conten...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02550-6
更新日期：2000-08-11 00:00:00
abstract：:cGMP was proposed to be the agent which directly opens the light-sensitive channel in Limulus ventral photoreceptors. However, the light-sensitive rhabdomeral-lobe (R-lobe) is not uniformly responsive to cGMP injection; that is, there are 'hot spots' of sensitivity. A potent phosphodiesterase which rapidly hydrolyses ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90094-c
更新日期：1991-06-28 00:00:00
abstract：:Using an immunoperoxidase technique, somatostatin-28-like immunoreactive (LIR) neurons were observed in the main and accessory olfactory bulb (MOB and AOB) of adult rats. In the MOB, a restricted population of periglomerular cells in the glomerular layer, some superficial short-axon cells in the juxtaglomerular layer,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91242-9
更新日期：1990-09-03 00:00:00
abstract：:Previous studies have reported that high concentrations of homocysteine and lower concentrations of vitamins B6, B12, and folate increase the risk for cognitive decline and pathology in aging populations. In this cross-sectional study, high resolution magnetic resonance imaging (MRI) scans and a 3-day food diary were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.01.030
更新日期：2008-03-14 00:00:00
abstract：:Previous studies have demonstrated that some anticonvulsant drugs can modulate tolerance to the opioid analgesia. In the present study, the effects of lamotrigine (LTG) on the development and expression of tolerance to the morphine-induced antinociception were evaluated using tail-flick test. To assess the LTG effects...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.014
更新日期：2009-09-29 00:00:00
abstract：:Neurturin (NTN) is a recently discovered neurotrophic factor related to glial cell line-derived neurotrophic factor (GDNF) and has a wide spectrum of biological roles in different types of neurons in the central and peripheral nervous systems. However, information on its expression in peripheral tissues has been limit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01590-5
更新日期：1999-07-24 00:00:00
abstract：:The resurgent Na(+) current (I(NaR)) is a component of neuronal voltage-dependent Na(+) currents that is activated by repolarization and is believed to result from an atypical path of Na(+)-channel recovery from inactivation. So far, I(NaR) has only been identified in a small number of central neuronal populations in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.05.065
更新日期：2007-08-13 00:00:00
abstract：:Protein uptake and transport within the brain stem vasculature of mechanically brain injured cats was studied by means of both light and electron microscopy utilizing intravenously injected horseradish peroxidase as the protein tracer. In animals sustaining low grade head injuries not of sufficient intensity to elicit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90404-3
更新日期：1978-09-22 00:00:00
abstract：:The competitive CB1 receptor antagonist SR141716A was used to test the hypothesis that endogenous cannabinoids modulate tonic pain sensitivity. Pretreatment with the antagonist significantly enhanced the response to a chemical nociceptive stimulus in the formalin test. Postreatment with the antagonist 5 min following ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01031-2
更新日期：1998-12-07 00:00:00
abstract：:To determine whether oculomotor internuclear neurons (INOs) establish unilateral or bilateral connections with the abducens nucleus (nVI), horseradish peroxidase (HRP) and either DAPI or Nuclear Yellow (NY) were injected into nVI and the oculomotor complex (nIII) examined for retrogradely labeled cells. Such injection...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90464-x
更新日期：1983-02-28 00:00:00
abstract：:Slices of rat hippocampus were exposed to 700 MHz continuous wave radiofrequency (RF) fields (25.2-71.0 V m(-1), 5-15 min exposure) in a stripline waveguide. At low field intensities, the predominant effect on the electrically evoked field potential in CA1 was a potentiation of the amplitude of the population spike by...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02434-9
更新日期：2001-06-15 00:00:00
abstract：:Maternal melatonin readily crosses the placenta to provide the fetus with time-of-day and day length information. To determine if melatonin could have a broader role during development than is currently recognized, melatonin receptor expression was examined in somatic sites during Siberian hamster embryogenesis. Using...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91424-y
更新日期：1991-12-24 00:00:00
abstract：:Hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons, the central regulators of the hypothalamic-pituitary-thyroid axis, are located in the paraventricular nucleus of the hypothalamus (PVN). These neurons are well-known to be stimulated by cold exposure through activation of ascending brainstem pa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.094
更新日期：2009-10-19 00:00:00
abstract：:The effect of the xanthine derivative propentofylline (HWA 285) on metabolic and functional recovery in rabbit spinal cord after 20 and 30 min ischemia and 4 days of reperfusion was investigated. Pre-treatment with 20 mg/kg significantly improved recovery of the energy state in the spinal cord, however, without signif...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91114-t
更新日期：1992-09-11 00:00:00
abstract：:The optic nerve of anesthetized cats was completely cut and the autologous sciatic nerve was transplanted. Sixty days later some populations of retinal ganglion cells were shown to regenerate the axon with retrograde HRP labeling. We verified that ganglion cells that had projected to the lateral geniculate nucleus (LG...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91253-w
更新日期：1991-09-27 00:00:00
abstract：:The objective of this study was to determine whether the aging process influences the changes in the electrophysiological properties of motoneurons that occur as a consequence of axotomy. Accordingly, using intracellular recording and stimulating techniques, the basic electrical properties of control (unaxotomized) an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90594-y
更新日期：1992-01-20 00:00:00
