Abstract：
:Male rats were treated with barbital in their drinking fluid for about 40 weeks (daily dose 200 mg/kg). The treatment was stopped on day 0 and the number of muscarinic binding sites was measured in 3 brain parts (striatum; cortex and hippocampus; medulla oblongata and midbrain) during the abstinence with labeled quinuclidinyl benzilate (QNB) as ligand. Nicotine-like binding sites were quantified in the cortex with labeled tubocurarine. An increased number of QNB-binding sites was found in the striatum during the early part of the abstinence (days 0--3), found by another increase later in the abstinence (days 12--21). In the cortex preparation a variable increase in QNB binding was measured from days 2--9 of the abstinence, whereas in the midbrain preparation the QNB binding was found to be increased only on day 9 in comparison to controls. A change in the proportion between high and low affinity muscarinic binding sites (measured by agonist-antagonist competition) was found in the cortex preparation during the period when the QNB binding was increased. Prior to the maximum abstinence convulsions the QNB binding was higher in rats without recorded spontaneous convulsions in comparison to rats with convulsions. A negative correlation between the time after the last convulsion and the number of QNB binding sites was observed in data from rats where the maximum convulsions had occurred before sacrifice. In addition, a negative relationship between the number of muscarine- and nicotine-like binding sites was found in the cortex during days 5--9 of the abstinence.
journal_name
Brain Resjournal_title
Brain researchauthors
Nordberg A,Wahlström Gdoi
10.1016/0006-8993(82)90146-9subject
Has Abstractpub_date
1982-08-19 00:00:00pages
105-12issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(82)90146-9journal_volume
246pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Proliferative response of astrocytes to unilateral injury of the cerebral hemisphere was investigated in 30-day-old rats using a combination of [3H]thymidine autoradiography and immunocytochemical staining for glial fibrillary acidic protein. At different intervals following injury the animals were injected with [3H]t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90566-0
更新日期：1989-04-24 00:00:00
abstract：:To elucidate the intracellular mechanism of seizure discharge, phosphorylation of cellular protein during pentylenetetrazole (PTZ)-induced bursting activity in snail neurons was investigated. PTZ markedly enhanced the phosphorylation of proteins of 34,000 and 50,000 molecular weight. Similar effects were observed by a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91395-8
更新日期：1986-01-01 00:00:00
abstract：:For the evaluation of glutamatergic and GABAergic transmission during seizures, rat hippocampal CA1 and CA3 areas were separately assessed by brain microdialysis, and extracelluar glutamate and GABA were measured through the course of the seizures after a systemic administration of kainic acid (KA). The generalized co...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00507-1
更新日期：1998-07-27 00:00:00
abstract：:Thalamocortical connections were studied after injections of retrograde tracers were made into rostral or caudal parts of cortical area Fr2 in adult rats. The data reveal that both rostral Fr2 (rFr2) and caudal Fr2 (cFr2) receive input from the centrolateral, central medial, interanteromedial, mediodorsal, paracentral...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91420-6
更新日期：1991-12-24 00:00:00
abstract：:To test the hypothesis that there is a functional modulation of conventional EEG bands associated with preparatory attention, putative changes in the spontaneous brain rhythms and their associated cerebral sources were addressed. The goals of the present report were, first, to find the brain areas with maximal rhythmi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.06.019
更新日期：2006-08-30 00:00:00
abstract：:Generation and persistence of tinnitus following hearing loss may be due to aberrant engagement of attention. Here, functional MRI was used to determine differences in auditory and visual attention processing in adults with tinnitus and hearing loss compared to two age-matched control groups, one with matched hearing ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.05.010
更新日期：2015-09-16 00:00:00
abstract：:A highly specific antibody to alpha-melanocyte stimulating hormone (alpha-MSH) was used to histochemically localize and biochemically identify and quantitate alpha-MSH immunoreactivity in nerve fibers and cell bodies of the rat brain. alpha-MSH-like immunoreactivity was contained in fibers throughout the brain. The di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90873-4
更新日期：1979-10-26 00:00:00
abstract：:Electrical stimulation of the chorda tympani nerve (CT; innervating taste buds on the rostral tongue) is known to initiate recurrent inhibition in cells in the nucleus of the solitary tract (NTS, the first central relay in the gustatory system). Here, we explored the relationship between inhibitory circuits and the br...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.03.069
更新日期：2009-06-12 00:00:00
abstract：:To test the hypothesis that enkephalins, substance P, bradykinin and angiotensin II could act as neurohumoral modulators of hypothalamic function, these peptides (0.01-20 microgram) were injected into the general circulation of anesthetized rats, and changes in hypothalamo-neurohypophysial activity were determined by ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90214-6
更新日期：1981-09-07 00:00:00
abstract：:During normal aging, men experience a significant decline in testosterone levels and a compensatory elevation in levels of gonadotropin luteinizing hormone (LH). Both low testosterone and elevated LH have been identified as significant risk factors for the development of Alzheimer's disease (AD) in men. It is unclear ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.05.011
更新日期：2012-07-23 00:00:00
abstract：:The effects of repetitive pilocarpine-induced status epilepticus (SE) in the hippocampal Na(+)/K(+)ATPase activity were studied in developing rat. Na(+)/K(+)ATPase is a membrane-bound enzyme responsible for the active transport of sodium and potassium ions through the membrane. It is necessary to maintain neuronal exc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.12.068
更新日期：2007-03-23 00:00:00
abstract：:In larval lamprey 4 weeks after a spinal transection locomotor patterns were usually complete along the body in whole animals. In in vitro preparations locomotor activity was restricted to a few millimeters below the transection. Retrograde labeling indicated that descending axons from a few brainstem neurons had grow...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90252-i
更新日期：1993-01-29 00:00:00
abstract：:Using an immunocytochemical technique we have analyzed changes in substance P, somatostatin, calcitonin gene-related peptide, and galanin immunoreactivity pattern in the rat dorsal root ganglia. After 7 days of adrenalectomy, sham operated rats were compared with adrenalectomized animals either receiving a daily intra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91893-7
更新日期：1994-03-21 00:00:00
abstract：:In order to establish the basic connectivity of physiologically identified somatosensory regions of the thalamus and telencephalon in the pigeon, injections of wheatgerm agglutinin-horseradish peroxidase were made under electrophysiological control and the projections were charted following conventional neurohistochem...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/0006-8993(87)91127-9
更新日期：1987-06-02 00:00:00
abstract：:The effects of the dopamine transporter (DAT) inhibitors cocaine and GBR12909 on DAT and dopamine D(2) receptors were evaluated in the brains under awake and isoflurane-anesthetized monkeys using high-resolution positron emission tomography (PET) in combination with microdialysis. The striatal DAT availability and dop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02018-1
更新日期：1999-12-04 00:00:00
abstract：:Unilateral visual cortex ablations in neonatal rabbits produced no detectable loss of ganglion cells in the contralateral retina following a survival period of 3, 4 or 8 months. Analysis of neuron size distributions and neuron densities from whole-mounted retinas indicate that transneuronal retrograde degeneration doe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90218-4
更新日期：1985-08-01 00:00:00
abstract：:Inhibitory GABAergic synaptic transmission in the mammalian hippocampus depends upon a hyperpolarized reversal potential for Cl(-) (ECl). To examine the regulation of ECl hyperpolarization we cultured hippocampal neurons for two weeks in either a low- or a high-concentration of KCl (2.6 or 18.7 mM, respectively). Neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.038
更新日期：2008-04-18 00:00:00
abstract：:Extracellular recordings from the supraoptic nucleus of the rat established that vasopressinergic neurosecretory cells were excited by stimulation of cervical but not abdominal vagal afferents. This response was absent or significantly attenuated after microinjection of gamma-aminobutyric acid into a region of the cau...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91131-w
更新日期：1992-10-30 00:00:00
abstract：:Sokoloff's [14C]2-deoxyglucose method has been applied to investigate circadian variations in local cerebral glucose utilization (LCGU). Freely moving rats were tested during two phases of the circadian light/dark cycle. In the rats tested during darkness, elevations in LCGU, when compared with animals tested during t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91460-1
更新日期：1989-12-29 00:00:00
abstract：:Small injections of the lectin Phaseolus vulgaris-leucoagglutinin (PHA-L) in the external segment of the pallidum (GPe) in the squirrel monkey (Saimiri sciureus) and in the rhesus monkey (Macaca mulatta) led to anterograde labeling of fibers in the internal segment of the pallidum (GPi). These fibers formed numerous l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91813-v
更新日期：1990-11-12 00:00:00
abstract：:Newly synthesized serotonin (5-HT) can be released in the nodose ganglion from the nerve cell bodies of vago-aortic serotoninergic neurones. Free-calcium led to a decrease of spontaneous and potassium-evoked release. The veratridine-stimulating response was abolished by TTX. The concept that 5-HT released from perikar...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90877-1
更新日期：1984-06-18 00:00:00
abstract：:We sought to identify the areas that have altered neuronal activity within the hypothalamus of rats with heart failure (HF) by mapping neuronal staining of c-Fos protein (Fos) 6-8 weeks following coronary artery ligation (HF group; n=17) or sham surgery (sham-operated control group, n=15). Fos-like immunoreactivity wa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02186-7
更新日期：2000-05-19 00:00:00
abstract：:Cerebral accumulation of amyloid beta protein (Abeta) is believed to play a central role in the pathogenesis of Alzheimer's disease (AD). Insulin degrading enzyme (IDE) is involved in Abeta degradation, therefore the gene encoding for insulin degrading enzyme is one of the candidate genes risky for AD. In Chinese Han ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.10.034
更新日期：2009-01-16 00:00:00
abstract：:Most experimental spinal cord injury studies described to date have relied on a limited number of injury gradations, and have tacitly assumed that outcome (functional, histological, and/or neurophysiological) is a monotonically graded function of injury severity. In contrast, the present study provides evidence that f...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-08-05 00:00:00
abstract：:The intracerebroventricular injection (1 microgram) of murine corticotropin-releasing factor (r-CRF) to rats after 72 h of sleep deprivation markedly postponed the sleep onset, reduced slow wave sleep and prolonged the duration of paradoxical sleep (PS) episodes. Moreover, CRF is-to our knowledge-the first compound to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90614-h
更新日期：1990-05-07 00:00:00
abstract：:Previously brain norepinephrine (NE) neurons in the locus coeruleus (LC) have been shown to respond profoundly to external, environmental stimuli and are thought to be involved in behavioral functions such as vigilance, alarm and anxiety reactions to novel and, especially, threatening stimuli. Here we have used electr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90964-9
更新日期：1986-06-04 00:00:00
abstract：:Systemic administration of the protein synthesis inhibitor, cycloheximide, induced both phase advances and phase delays in the circadian rhythm of wheel-running activity in hamsters (Mesocricetus auratus) maintained in constant darkness or constant light. The magnitude and direction of the phase shifts were dependent ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91053-6
更新日期：1989-09-04 00:00:00
abstract：:An autoradiographic determination of the time of origin of the lateral motor columns (LMC) of the chick embryo has been made. The first motor neurons of the brachial LMC are born at stage 15; the earliest birthdates of lumbar LMC neurons are at stage 17. At least 95% of the motor neurons of both brachial and lumbar co...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90416-4
更新日期：1977-08-26 00:00:00
abstract：:The effects of diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), on the fast tetrodotoxin-sensitive (TTX-S) and the slow tetrodotoxin-resistant (TTX-R) sodium currents in rat dorsal root ganglion neurons were investigated using the whole-cell patch-clamp method. Diclofenac suppressed both sodium currents in a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.08.048
更新日期：2003-11-28 00:00:00
abstract：:Pretreatment with the alpha(2)-adrenoceptor agonist clonidine (31.25, 62.5, or 125 microg/kg, i.p.) dose-dependently reduced long-term potentiation (LTP) elicited in vivo in the occipital cortex of anesthetized rats, whereas pretreatment with the alpha(2)-adrenoceptor antagonist yohimbine (0.133, 0.4, or 1.2 mg/kg, i....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.07.020
更新日期：2004-09-24 00:00:00
