An autoradiographic study of the formation of the lateral motor column in the chick embryo.

Abstract:

:An autoradiographic determination of the time of origin of the lateral motor columns (LMC) of the chick embryo has been made. The first motor neurons of the brachial LMC are born at stage 15; the earliest birthdates of lumbar LMC neurons are at stage 17. At least 95% of the motor neurons of both brachial and lumbar columns are produced by stage 23 (4 days). The remaining 5% of the motor neurons are produced during the next two days. A clear rostrocaudal gradient of motor neuron production is seen beoth between the brachial and lumbar LMCs and within the LMCs themselves. The LMCs are assembled in a mediolateral sequence: the early-born motor neurons settle medially, the later-born motor neurons settle more laterally. Observations were made of other large early-born neurons which remain permanently in the dorsal gray of the spinal cord.

journal_name

Brain Res

journal_title

Brain research

authors

Hollyday M,Hamburger V

doi

10.1016/0006-8993(77)90416-4

subject

Has Abstract

pub_date

1977-08-26 00:00:00

pages

197-208

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(77)90416-4

journal_volume

132

pub_type

杂志文章
  • Prenatal choline supplementation in rats increases the expression of IGF2 and its receptor IGF2R and enhances IGF2-induced acetylcholine release in hippocampus and frontal cortex.

    abstract::Choline is an essential nutrient whose availability during the second half of gestation produces long-lasting cognitive effects. Rats that obtain supplemental choline during embryonic day (E) 11-17 have enhanced depolarization-evoked acetylcholine (ACh) release from hippocampal slices, whereas choline deficiency durin...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.08.046

    authors: Napoli I,Blusztajn JK,Mellott TJ

    更新日期:2008-10-27 00:00:00

  • Illness-induced hyperalgesia is mediated by spinal neuropeptides and excitatory amino acids.

    abstract::The spinal cord dorsal horn contains neural mechanisms which can greatly facilitate pain. We have recently shown that 'illness'-inducing agents, such as intraperitoneally administered lipopolysaccharide (LPS; bacterial endotoxin), can produce prolonged hyperalgesia. This hyperalgesic state is mediated at the level of ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91948-8

    authors: Watkins LR,Wiertelak EP,Furness LE,Maier SF

    更新日期:1994-11-21 00:00:00

  • Three-dimensional morphology and distribution of pallidal axons projecting to both the lateral region of the thalamus and the central complex in primates.

    abstract::This study presents a three-dimensional analysis of pallido-thalamic axons and axonal endings in the monkey (Macaca mulatta and M. irus). Injections of the anterograde tracer biocytin were made in the dorsal, associative region of the medial pallidum. Numerous axonal endings were observed within the pallidal territory...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00181-9

    authors: Arecchi-Bouchhioua P,Yelnik J,François C,Percheron G,Tandé D

    更新日期:1997-04-18 00:00:00

  • Age-related changes in CREB binding protein immunoreactivity in the cerebral cortex and hippocampus of rats.

    abstract::Although the role of cAMP-response-element-binding protein (CREB) binding protein (CBP) in the neuroprotective mechanisms has been the focus of many studies, very little is known about the expression or function of CBP in aged brains. We have therefore examined age-related changes in CBP expression in the cerebral cor...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)03562-x

    authors: Chung YH,Kim EJ,Shin CM,Joo KM,Kim MJ,Woo HW,Cha CI

    更新日期:2002-11-29 00:00:00

  • Neural activation deficits in a mouse genetic model of NMDA receptor hypofunction in tests of social aggression and swim stress.

    abstract::Mice with reduced expression of the NR1 subunit of the NMDA receptor (NR1 hypomorphic mice) display altered behavioral phenotypes that may relate to behavioral characteristics of schizophrenia. Altered phenotypes in the NR1 hypomorphs include marked deficits in species-typical behavioral interactions in tests of socia...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.02.002

    authors: Duncan GE,Inada K,Farrington JS,Koller BH,Moy SS

    更新日期:2009-04-10 00:00:00

  • Effects of m-CPP in altering neuronal function: blocking depolarization in invertebrate motor and sensory neurons but exciting rat dorsal horn neurons.

    abstract::The compound m-chlorophenylpiperazine (m-CPP) is used clinically to manipulate serotonergic function, though its precise mechanisms of actions are not well understood. m-CPP alters synaptic transmission and neuronal function in vertebrates by non-selective agonistic actions on 5-HT(1) and 5-HT(2) receptors. In this st...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)02271-6

    authors: Sparks GM,Brailoiu E,Brailoiu GC,Dun NJ,Tabor J,Cooper RL

    更新日期:2003-04-18 00:00:00

  • Changes in [3H]zolpidem and [3H]Ro 15-1788 binding in rat globus pallidus and substantia nigra pars reticulata following a nigrostriatal tract lesion.

    abstract::Changes in GABA(A) receptor alpha(1) subunit gene expression occur in the globus pallidus and substantia nigra pars reticulata following lesions of the nigrostriatal tract. To determine whether these changes are translated at the protein level, we performed quantitative autoradiography with the alpha(1) selective liga...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02081-3

    authors: Chadha A,Howell O,Atack JR,Sur C,Duty S

    更新日期:2000-04-17 00:00:00

  • Nerve growth factor selectively increases cholinergic markers but not neuropeptides in rat basal forebrain in culture.

    abstract::We have previously used organotypic cultures to study mechanisms regulating phenotypic expression of neurotransmitter characters in the brain. Our previous work indicated that nerve growth factor (NGF) specifically increased the activity of choline acetyltransferase (CAT) in striatal cholinergic interneurons. In the p...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)91136-x

    authors: Martínez HJ,Dreyfus CF,Jonakait GM,Black IB

    更新日期:1987-06-02 00:00:00

  • Sex-dependent and region-specific changes in TrkB signaling in BDNF heterozygous mice.

    abstract::Altered expression of neurotrophins may contribute to the pathogenesis of schizophrenia. Several studies suggest sex steroid hormones may be involved in the regulation of brain-derived neurotrophic factor (BDNF) signaling, as well as the symptoms of schizophrenia. This study aimed to identify sex differences in BDNF-T...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2011.01.060

    authors: Hill RA,van den Buuse M

    更新日期:2011-04-12 00:00:00

  • Involvement of N-methyl-D-aspartate receptor in the delayed transneuronal regression of substantia nigra neurons in rats.

    abstract::The substantia nigra pars reticulata (SNr) receives both inhibitory GABAergic and excitatory glutamatergic afferents from diverse origins. Ischemic injury to the striatum and/or the globus pallidus causes delayed transneuronal death of the SNr neurons, in the course of which neuronal disinhibition induced by loss of G...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(96)01052-9

    authors: Yamada K,Goto S,Yoshikawa M,Okamura A,Ushio Y

    更新日期:1996-12-16 00:00:00

  • Expression of only one myelin basic protein allele in mouse is compatible with normal myelination.

    abstract::Myelin deficiency (mld) is an autosomal recessive mutation in mice characterized by a severe myelin deficit in the central nervous system (CNS). The primary defect in mld is a reduction of the synthesis of the myelin basic protein (MBP) and probably lies in a regulatory element of the MBP gene. In young mld heterozygo...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0169-328x(87)90045-3

    authors: Roch JM,Cooper BJ,Ramirez M,Matthieu JM

    更新日期:1987-12-01 00:00:00

  • Functional rescue of the inactive splice variant of the dopamine D3 receptor D3nf.

    abstract::We previously found that the dopamine D3 receptor can be split at the third cytoplasmic loop into two fragments (D3trunk and D3tail), and that the mixture of the two fragments retains the binding and functional activity of the wild type receptor. The dopamine D3 receptor gene gives rise to several inactive receptor sp...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)03360-2

    authors: Scarselli M,Novi F,Corsini GU,Maggio R

    更新日期:2003-10-17 00:00:00

  • Unit activity of amygdala and hippocampal neurons: effects of morphine and benzodiazepines.

    abstract::The effects of morphine sulfate and two benzodiazepine derivatives, chlordiazepoxide HCl and diazepam, were evaluated upon single unit activity of the amygdaloid nuclear complex and hippocampal formation in immobilized cats. All surgical procedures were performed under halothane anesthesia and all wound margins were i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(77)90595-9

    authors: Chou DT,Wang SC

    更新日期:1977-05-13 00:00:00

  • G-protein effects on retrograde axonal transport.

    abstract::Movements of medium and large sized membranous organelles (0.5-1 microns in diameter) were visualized within segments of the crab walking leg nerve with Nomarski differential interference contrast optics and subjected to video contrast enhancement. Accessibility to the axoplasm was demonstrated by intra-axonal fluores...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)91754-g

    authors: Moshiach S,Nelson TJ,Sanchez-Andres JV,Sakakibara M,Alkon DL

    更新日期:1993-03-12 00:00:00

  • Behavioral, electrophysiological, and histopathological consequences of mild fluid-percussion injury in the rat.

    abstract::Metabolic dysfunction in the relay nuclei of the rat vibrissa circuit follows traumatic brain injury (TBI). This study examined the effects of mild (1.4-1.5 atm) parasagittal fluid-percussion injury on the electrophysiology of this circuit. TBI caused significant reductions in slope and increases in latency of vibriss...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02424-6

    authors: Sanders MJ,Dietrich WD,Green EJ

    更新日期:2001-06-15 00:00:00

  • Effects of sciatic nerve transplants after fimbria-fornix lesion: examination of the role of nerve growth factor.

    abstract::At two weeks post-transplantation, sciatic nerves inserted into the lesioned septo-hippocampal pathway contain NGF levels more than twice that of normal nerves. These transplanted nerves also contain regenerating cholinergic axons. Moreover, transplanted animals exhibit septal NGF levels that are significantly greater...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90147-n

    authors: Messersmith DJ,Fabrazzo M,Mocchetti I,Kromer LF

    更新日期:1991-08-23 00:00:00

  • Estrogen-induced neurochemical and electrophysiological changes in the parabrachial nucleus of the male rat.

    abstract::Estrogen has previously been shown to significantly change sympathetic and parasympathetic system output via an action within the central nuclei responsible for regulating autonomic tone. These estrogen-induced changes were observed within 30 min of systemic administration and could be blocked by the direct microinjec...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)03387-0

    authors: Saleh TM,Connell BJ,McQuaid T,Cribb AE

    更新日期:2003-11-14 00:00:00

  • Sleep deprivation in rats with preoptic/anterior hypothalamic lesions.

    abstract::Chronic total sleep deprivation (TSD) of rats by the disk-over-water method reliably produces initial increases and subsequent decreases in waking intraperitoneal (Tip) and hypothalamic (Thy) temperatures, progressive increases in energy expenditure, skin lesions on the tail and plantar surfaces, debilitated appearanc...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)01071-8

    authors: Feng PF,Bergmann BM,Rechtschaffen A

    更新日期:1995-12-12 00:00:00

  • The ontogeny of seizures in a rat model of limbic epilepsy: evidence for a kindling process in the development of chronic spontaneous seizures.

    abstract::Kindling is an experimental model for epilepsy in which repeated stimuli induce longer electrographic seizures and eventually cause behavioral convulsions. Although kindling has some features that are similar to chronic human epilepsy, it is not known whether this process plays a role in the development of chronic sei...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)91071-y

    authors: Bertram EH,Cornett J

    更新日期:1993-10-22 00:00:00

  • Neurotoxicity of MPTP and MPP+ in vitro: characterization using specific cell lines.

    abstract::The effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its putative toxic metabolite 1-methyl-4-phenylpyridinium ion MPP+ were studied with specific neuronal and glial cell lines in vitro. MPTP had no morphological effect on actively growing neuroblastoma N2AB-1 cells or C6 glioma cells nor did it affe...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90225-9

    authors: Notter MF,Irwin I,Langston JW,Gash DM

    更新日期:1988-07-26 00:00:00

  • The accumulation of brain injury leads to severe neuropathological and neurobehavioral changes after repetitive mild traumatic brain injury.

    abstract::Traumatic brain injury (TBI) is a major public health problem with long-term neurobehavioral sequela. The evidences have revealed that TBI is a risk factor for later development of neurodegenerative disease and both the single and repetitive brain injury can lead to the neurodegeneration. But whether the effects of ac...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2016.11.028

    authors: Gao H,Han Z,Bai R,Huang S,Ge X,Chen F,Lei P

    更新日期:2017-02-15 00:00:00

  • Chronoamperometry in brain slices: quantitative evaluations of in vivo electrochemistry.

    abstract::Practical utilization of in vivo electrochemistry for brain studies has been impeded by difficulties with specificity and quantitative measurements. Studies in brain slices combined with similar data from intact animals have provided important new information on the nature of the electrochemical studies. Using the enz...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90901-0

    authors: Schenk JO,Miller E,Rice ME,Adams RN

    更新日期:1983-10-24 00:00:00

  • Influenza A(H1N1) vaccination during early pregnancy transiently promotes hippocampal neurogenesis and working memory. Involvement of Th1/Th2 balance.

    abstract::The 2009 influenza A(H1N1) pandemic led to a particularly high risk of morbidity and mortality among pregnant women. Therefore, inactivated influenza vaccines have been widely recommended for women in any period of gestation. Recent studies have shown that the peripheral adaptive immune system plays an important role ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2014.09.076

    authors: Xia Y,Qi F,Zou J,Yao Z

    更新日期:2014-12-10 00:00:00

  • A method for recording miniature inhibitory postsynaptic currents in the central nervous system suitable for quantal analysis.

    abstract::Quantal analysis of transmitter release is useful in examining presynaptic mechanisms involved in synaptic transmission. However, in central neurons, the presence of multiple synapses makes it difficult to use the traditional quantal analysis, developed for the neuromuscular transmission. We developed a method to mini...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.02.056

    authors: Singh G,Xu JY,Sastry BR

    更新日期:2008-05-01 00:00:00

  • In vivo and in vitro labelling of perineuronal nets in rat brain.

    abstract::Previous lectin-histochemical and immunocytochemical investigations using fixed tissue revealed perineuronal nets as lattice-like accumulations of extracellular matrix proteoglycans at the surface of several types of neurons. In the present study, perineuronal nets in the rat brain were labelled for the first time in ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(96)00152-7

    authors: Brückner G,Bringmann A,Köppe G,Härtig W,Brauer K

    更新日期:1996-05-13 00:00:00

  • Reticularis thalami afferents to the ventrobasal complex of the rat thalamus: an electron microscope study.

    abstract::Afferents from the nucleus reticularis thalami (RT) to the thalamic ventrobasal complex were studied in the rat by looking for degenerating terminals after selective neurotoxic lesion of RT using injections of kainic acid. Several lines of evidence are presented indicating that RT afferents terminate in the VB by F ty...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90607-8

    authors: Peschanski M,Ralston HJ,Roudier F

    更新日期:1983-07-04 00:00:00

  • A firing rate model of Parkinsonian deficits in interval timing.

    abstract::To account for deficits in interval timing observed in Parkinson's Disease (PD) patients, we develop a model based on the accumulating firing rate of a neural population with recurrent excitation. This model naturally produces the curvilinear accumulation of neural activity introduced to timing psychophysics by Miall ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.10.070

    authors: Shea-Brown E,Rinzel J,Rakitin BC,Malapani C

    更新日期:2006-01-27 00:00:00

  • Concordance of quantitative damage within the diencephalon and telencephalon following systemic pilocarpine (380 mg/kg) or lithium (3 mEq/kg)/pilocarpine (30 mg/kg) induced seizures.

    abstract::We tested the hypothesis that a single systemic injection of 380 mg/kg of the muscarinic agonist pilocarpine would produce more diffuse and severe seizure-induced brain damage than a single injection of lithium (3 mEq/kg) followed 4 h later by < 1/10 the dosage of pilocarpine. The hypothesis was not supported; the pat...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91126-6

    authors: Bureau YR,Peredery O,Persinger MA

    更新日期:1994-06-20 00:00:00

  • Long-lasting distortion of GABA signaling in MS/DB neurons after binge-like ethanol exposure during initial synaptogenesis.

    abstract::Using a well-established model of binge-like ethanol treatment of rat pups on postnatal days (PD) 4-9, we found that maturation of GABAA receptor (GABAAR) miniature postsynaptic currents (mPSCs) was substantially blunted for medial septum/diagonal band (MS/DB) neurons in brain slices on PD 11-16. Ethanol reduced mPSC ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2013.04.054

    authors: Wang H,DuBois DW,Tobery AN,Griffith WH,Brandt P,Frye GD

    更新日期:2013-07-03 00:00:00

  • Expression of secreted semaphorins and their receptors in specific neuromeres, boundaries, and neuronal groups in the developing mouse and chick brain.

    abstract::Semaphorins constitute a family of signaling molecules with functions in axon pathfinding and neuronal migration. Neuropilins 1 and 2 have been identified as the ligand-binding component of semaphorin receptors. Both ligands and receptors are expressed in embryonic and adult organs in complementary and sometimes redun...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.10.028

    authors: Meléndez-Herrera E,Varela-Echavarría A

    更新日期:2006-01-05 00:00:00