Abstract:
:We previously found that the dopamine D3 receptor can be split at the third cytoplasmic loop into two fragments (D3trunk and D3tail), and that the mixture of the two fragments retains the binding and functional activity of the wild type receptor. The dopamine D3 receptor gene gives rise to several inactive receptor splice variants, one of which is the D3nf. Since this gene variant very closely resembles our D3trunk fragment, in this study we investigated if the transfection of D3nf with D3tail could result in the rescue of a functional dopamine receptor. Our experiments showed that D3tail can indeed rescue the activity of D3nf, and that the pharmacological profile of this split D3nf/D3tail receptor is identical to that of the wild type D3 receptor.
journal_name
Brain Resjournal_title
Brain researchauthors
Scarselli M,Novi F,Corsini GU,Maggio Rdoi
10.1016/s0006-8993(03)03360-2subject
Has Abstractpub_date
2003-10-17 00:00:00pages
244-7issue
2eissn
0006-8993issn
1872-6240pii
S0006899303033602journal_volume
987pub_type
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