Abstract：
:Pretreatment with the alpha(2)-adrenoceptor agonist clonidine (31.25, 62.5, or 125 microg/kg, i.p.) dose-dependently reduced long-term potentiation (LTP) elicited in vivo in the occipital cortex of anesthetized rats, whereas pretreatment with the alpha(2)-adrenoceptor antagonist yohimbine (0.133, 0.4, or 1.2 mg/kg, i.p.) increased neocortical LTP in a dose-dependent fashion. These effects could be related to the reported disruptive and facilitatory actions induced on memory formation by pretreatment with alpha(2)-adrenoceptor agonists and antagonists, respectively.
journal_name
Brain Resjournal_title
Brain researchauthors
Mondaca M,Hernández A,Pérez H,Valladares L,Sierralta W,Fernández V,Soto-Moyano Rdoi
10.1016/j.brainres.2004.07.020subject
Has Abstractpub_date
2004-09-24 00:00:00pages
292-6issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(04)01138-2journal_volume
1021pub_type
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