Abstract：
:Glutamate (2.5 mg) was administered after the blood-brain barrier had been opened by a unilateral intracarotid infusion of 5 mg protamine sulfate in rats. Whereas the brain specific gravity, measured 24 h later, did not differ between the injected and non-injected side after protamine alone, glutamate significantly reduced the specific gravity in the right hemisphere indicating brain edema (P less than 0.01). NBQX, a potent AMPA receptor antagonist, significantly reduced the edema (P less than 0.01) and completely inhibited the glutamate mediated increase in albumin content in cerebrospinal fluid (P less than 0.01).
journal_name
Brain Resjournal_title
Brain researchauthors
Westergren I,Johansson BBdoi
10.1016/0006-8993(92)90781-4subject
Has Abstractpub_date
1992-02-28 00:00:00pages
324-6issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(92)90781-4journal_volume
573pub_type
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