Abstract:
:The distribution of S-100-immunoreactive material was examined in the central nervous system of the gastropod snail. Helix pomatia, and electrophysiological properties of S-100-positive neurons were characterized. Immunocytochemical studies revealed S-100-like protein to be present in neurons localized in the cerebral, left parietal, and visceral ganglia, but not in glial cells. Among the immunoreactive neurons we identified the giant cells LPa3 and LPa4. Western blots showed a single S-100-immunoreactive band at 12-14 kDa. S-100-positive neurons are distinguished by spontaneous discharge activity in a beating or bursting mode and a prominent Ca(2+)-activated potassium outward current. Our result show that a S-100-like protein exclusively present in neurons of the Helix central nervous system is correlated with spontaneous discharge activity of these cells.
journal_name
Brain Resjournal_title
Brain researchauthors
Kubista H,Kerschbaum HH,Hermann Adoi
10.1016/0006-8993(95)01584-1subject
Has Abstractpub_date
1996-04-15 00:00:00pages
53-8issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(95)01584-1journal_volume
716pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Single unit extracellular recordings were obtained from cat lumbar spinal cord dorsal horn neurons activated by cutaneous inputs. The effect of electrical conditioning stimuli applied to the red nucleus (RN) was predominantly that of inhibition although in some cases excitation was seen. All the neurons that projected...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91413-6
更新日期:1984-10-08 00:00:00
abstract::Effect of beta-agkistrodotoxin (beta-AgTx), a presynaptic neurotoxin purified from snake venom, on large-conductance calcium-activated potassium channels (BK(Ca)) was studied in rat hippocampal CA1 pyramidal neurons using inside-out configuration of patch-clamp technique. The results showed that in equimolar K+ (150 m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02560-x
更新日期:2002-06-14 00:00:00
abstract::Buffy coat of three members from a family with Alzheimer's disease was inoculated into hamster brains. Eighteen months after the inoculation, all experimental animals were sacrificed for the neuropathological study. Hematoxylin-eosin staining showed no gross vacuolar degeneration, or neuronal loss in the cortex. The s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90949-v
更新日期:1991-06-14 00:00:00
abstract::The mismatch negativity is an electrophysiological marker of auditory change detection in the event-related brain potential and has been proposed to reflect an automatic comparison process between an incoming stimulus and the representation of prior items in a sequence. There is evidence for two main functional subcom...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.07.079
更新日期:2008-07-18 00:00:00
abstract::Normal adult albino and Sprague-Dawley rats, under intraperitoneal Nembutal anesthesia, were used to demonstrate enzymatic activity in the choroid plexus and ventricular ependyma. The brain tissues were perfused or immersed with cold 2% glutaraldehyde and 8% sucrose in 0.1 M cacodylate buffer (pH 7.2-7.4) for 30 min a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)91035-0
更新日期:1981-10-19 00:00:00
abstract::We examined the expression of IL-6 in the substantia nigra pars reticulata (SNr) at various time points after transient (3 h) middle cerebral artery occlusion (MCAO) in rats. The animals were killed at 1, 3, 7 or 14 days following operation. Coronal brain sections were processed for immunohistochemistry with antibodie...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03129-2
更新日期:2001-01-19 00:00:00
abstract::The effects of ventromedial hypothalamic (VMH) stimulation on various metabolic parameters in freely moving animals were measured using a specific indirect calorimetric chamber associated with a quantitative measurement of locomotor activity, which allows the separate measurement of locomotor energy expenditure from t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01922-8
更新日期:1999-10-30 00:00:00
abstract::Many of our everyday actions are only appropriate in certain situations and selecting the appropriate behavior requires that we use current context and previous experience to guide our decisions. The current study examined hippocampal functional connectivity with prefrontal and striatal regions during a task that requ...
journal_title:Brain research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brainres.2011.09.038
更新日期:2011-11-14 00:00:00
abstract::The mechanisms responsible for the rate of rise (RR) of cumulative depolarization induced by dorsal root stimulus trains were investigated with intracellular recordings from motoneurones of the rat isolated spinal cord. The NMDA receptor antagonists CPP or APV depressed the cumulative depolarization but not its RR whi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00997-3
更新日期:1996-11-04 00:00:00
abstract::Aggression is a major source of social stress with negative effects on health and well-being, yet limited information is known about the molecular mechanisms mediating aggressive behavior in swine. Ractopamine (RAC) is a β-adrenoreceptor agonist that enhances growth but increases aggressive behaviors in female pigs. T...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.11.035
更新日期:2011-03-24 00:00:00
abstract::The 2009 influenza A(H1N1) pandemic led to a particularly high risk of morbidity and mortality among pregnant women. Therefore, inactivated influenza vaccines have been widely recommended for women in any period of gestation. Recent studies have shown that the peripheral adaptive immune system plays an important role ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.09.076
更新日期:2014-12-10 00:00:00
abstract::The role of mu opioid receptors in the nucleus raphe dorsalis (DR) in the control of apomorphine-induced aggression was studied in rats. Administration in the DR of a selective mu opioid receptor agonist, (D-Ala2,N-Me-Phe4,Gly5-ol)-enkephalin (DAGO), in doses ranging from 0.01 to 1 microgram/0.5 microliter, dose-depen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90706-3
更新日期:1989-05-29 00:00:00
abstract::We here review modulation of olfactory guided behavioral tasks by noradrenaline. In this review we focus on modulation of the main olfactory system in adult rodents. We detail behavioral paradigms commonly used and discuss how sensory perception and learning can be measured using these paradigms. We then describe neur...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2018.03.021
更新日期:2019-04-15 00:00:00
abstract::Peripheral afferent innervation appears to be required for the expression of the dopamine phenotype in the rodent main olfactory bulb. Experiments utilizing neonatal naris closure as a means of sensory deprivation also suggest that odor-induced afferent activity is required for the expression of the phenotype. These e...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91023-l
更新日期:1993-06-18 00:00:00
abstract::The subfornical organ (SFO), a neuroendocrine structure implicated in saltwater homeostasis, contains secretory structures histochemically similar to those in the neurohypophysis. Because of these morphological similarities, we compared levels of vasopressin (vp) in the SFO area and the adjacent hippocampal commissure...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90458-4
更新日期:1978-01-27 00:00:00
abstract::This study examined the hypothesis that the subfornical organ (SFO), a circumventricular organ with both osmosensitive elements and dipsogenic receptors for circulating angiotensin (ANG) II, is important for the water drinking response that follows an intragastric (ig) load of hypertonic NaCl. A 2-ml saline load was a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00249-2
更新日期:1998-06-08 00:00:00
abstract:BACKGROUND AND PURPOSE:The present study analyzed whether administration of sulindac, a non-steroidal anti-inflammatory drug (NSAID) would prevent, attenuate or repair ischemia induced brain injury and reverse functional impairment in a focal ischemia model of stroke. METHODS:Male Sprague-Dawley rats (weight 250-300 g...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.06.019
更新日期:2014-08-12 00:00:00
abstract::The present study was designed to investigate the role of activation of Kca+2 channels and cAMP in opioid-induced pial artery dilation in newborn pigs equipped with closed cranial windows. Methionine enkephalin, an endogenous mu agonist, elicited dilation that was modestly attenuated by the Kca+2 channel antagonist, i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01284-x
更新日期:1997-02-07 00:00:00
abstract::Our previous study [32] indicated that blockade of kappa-opioid receptors with nor-binaltorphimine (nor-BNI) in the medial preoptic area (MPOA) produced two different LH responses during midpregnancy in the rat: an increase in basal pulsatile LH secretion, followed in many cases by a larger and/or sustained increase i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00874-p
更新日期:1995-11-06 00:00:00
abstract::Structural and functional alterations of the putamen have been reported in patients with attention deficit hyperactivity disorder (ADHD), but the functional relationships between this area and other brain regions are seldom explored. In the present study, seed-based correlation analyses were performed in the resting-s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.08.029
更新日期:2009-12-15 00:00:00
abstract::Neural plasticity of afferent pain pathways that is induced by prolonged or repeated noxious stimuli may contribute to activate intrinsic inhibitory mechanisms in CNS. In order to clarify the role of the monoaminergic descending inhibitory system in acute nociception and inflammatory pain, we examined if this inhibito...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01086-5
更新日期:1998-12-14 00:00:00
abstract::In continuation of earlier computer simulation studies 15 of the feedback inhibition exercised by the Golgi cells of the cerebellum, an attempt is made at modeling the behavior of Purkinje and basket cells under somewhat more complex functional circumstances. The simulation study is based on a realistic network model ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(74)90531-9
更新日期:1974-03-15 00:00:00
abstract::Purkinje cell dendritic arborizations were studied in HRP intracellularly stained mature neurons grown during 30-50 days in organotypic cerebellar cultures from newborn kittens. The effects of afferent fiber depletions on the final dendritic topological parameters were investigated by computer assisted methods. Three ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90051-3
更新日期:1983-12-05 00:00:00
abstract::Acute forebrain ischemia reduced protein kinase C (PKC) activity in the adult rat cortex, striatum and hippocampus by 60-70% after 20 min ischemia episodes, followed by 48 h of recirculation. Ischemia of 1 min, followed by recirculation, produced a less pronounced but significant decrease in PKC activity. The ischemia...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91094-h
更新日期:1991-02-08 00:00:00
abstract::Short, high frequency stimulation bursts (4 pulses at 100 Hz) were applied to Schaffer/commissural projections to the CA1 field of rat hippocampal slices at 0.1, 0.2, 1.0 or 2.0-s intervals to assess their efficacy in eliciting long-term potentiation (LTP). Bursts repeated at 2-s intervals induced very little LTP; sho...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90579-2
更新日期:1986-03-19 00:00:00
abstract::The effect of a single subcutaneous (s.c.) injection of the ultrapotent capsaicin analogue resiniferatoxin (RTX) on responses of adult rats to noxious thermal and mechanical stimulation was examined. The effects of RTX treatment on the nociceptive flexor reflex and activity-dependent increase in spinal excitability af...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01444-8
更新日期:1997-03-28 00:00:00
abstract::Arg-vasopressin (AVP) containing neurons are one of the output paths from the suprachiasmatic nucleus (SCN), the center of the biological clock. AVP mRNA transcription is controlled by a negative feedback loop of clock genes. Circadian rhythm of melatonin release from the pineal gland is regulated by the SCN via the p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.04.052
更新日期:2004-07-09 00:00:00
abstract::In this study, we aimed at investigating the effect of an enriched environment (EE) on the recovery from chronic inflammatory pain. Inflammatory pain was induced by the injection of 2 mg of carrageenan (CAR) into the right knee of male Sprague-Dawley rats (n=34). Rats were housed either singly (S-housed) or in an EE (...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.04.039
更新日期:2009-06-18 00:00:00
abstract::The effects of retinoic acid (RA), a naturally occurring metabolite of vitamin A, on the growth, morphology and neurochemical differentiation of the PC12 clone of rat pheochromocytoma cells were investigated. RA added to the medium inhibited the growth of PC12 cells in a dose-dependent manner up to 10 microM without a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90460-5
更新日期:1989-11-13 00:00:00
abstract::These experiments examined the effects of intra-amygdala injections of NMDA receptor antagonists on the acquisition and retention of inhibitory avoidance. In Expt. I, rats received bilateral intra-amygdala injections of the NMDA antagonists D,L-AP5 (1-10 micrograms), D-AP5 (0.03-1 micrograms), CPP (0.125 or 0.375 micr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91188-k
更新日期:1992-07-10 00:00:00