Reduction of protein kinase C activity in the adult rat brain following transient forebrain ischemia.

abstract：:In vivo microdialysis combined with high performance liquid chromatography (HPLC) with electrochemical detection, was used to study the effect of MK-801 (0.1 mg/kg i.p.) on extracellular concentrations of dopamine (DA) 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT), norepinephrine (NE) and DOPAC/DA ratio in ...

journal_title：Brain research

authors： Hatip-Al-Khatib I,Mishima K,Iwasaki K,Fujiwara M

更新日期：2001-05-25 00:00:00

abstract：:Portions of cerebellar cortex, particularly Larsell's hemisphere VI, have been identified as involved but not essential for the acquisition and retention of classical conditioning of the nictitating membrane (NM) response in rabbit. The present experiment was undertaken to examine the effect of lesions of cerebellar c...

journal_title：Brain research

authors： Woodruff-Pak DS,Lavond DG,Logan CG,Steinmetz JE,Thompson RF

更新日期：1993-04-09 00:00:00

abstract：:In the present study, we assessed the beneficial synergistic effects of concurrent treatment with low doses of cilostazol and probucol against focal cerebral ischemic infarct in rats. The ischemic infarct induced by 2-h occlusion of middle cerebral artery (MCA) and 22-h reperfusion was significantly reduced in rat bra...

journal_title：Brain research

authors： Park SY,Lee JH,Kim CD,Rhim BY,Hong KW,Lee WS

更新日期：2007-07-09 00:00:00

abstract：:Using event-related potentials (ERPs), this study investigated the neuromechanism underlying verbal analogical reasoning of two different metaphorical relations: attributive metaphor and relational metaphor. The analogical reasoning of attributive metaphor (AM-AR) involves a superficial similarity between analogues, w...

journal_title：Brain research

authors： Zhao M,Meng H,Xu Z,Du F,Liu T,Li Y,Chen F

更新日期：2011-11-24 00:00:00

abstract：:Estrogen has previously been shown to significantly change sympathetic and parasympathetic system output via an action within the central nuclei responsible for regulating autonomic tone. These estrogen-induced changes were observed within 30 min of systemic administration and could be blocked by the direct microinjec...

journal_title：Brain research

authors： Saleh TM,Connell BJ,McQuaid T,Cribb AE

更新日期：2003-11-14 00:00:00

abstract：:Stress can precipitate onset of multiple mood-related disorders, including depression. Examination of the neural basis of this phenomenon has highlighted the amygdala as a key component. Alterations in amygdalar activity and structure accompany various mood-related disorders, and interestingly, amygdalar morphology an...

journal_title：Brain research

authors： Reznikov LR,Reagan LP,Fadel JR

更新日期：2009-02-23 00:00:00

abstract：:Variables influencing decision-making in real settings, as in the case of voting decisions, are uncontrollable and in many times even unknown to the experimenter. In this case, the experimenter has to study the intention to decide (vote) as close as possible in time to the moment of the real decision (election day). H...

journal_title：Brain research

authors： da Rocha AF,Rocha FT,Burattini MN,Massad E

更新日期：2010-09-10 00:00:00

abstract：:In the present studies we have examined the effects of a new calcium channel blocker, LY393615 ((N-Butyl-[5,5-bis-(4-fluorophenyl)tetrahydrofuran-2-yl]methylamine hydrochloride, NCC1048) in a model of hypoxia-hypoglycaemia in vitro and in a gerbil model of global and in two rat models of focal cerebral ischaemia in vi...

journal_title：Brain research

authors： O'Neill MJ,Hicks CA,Ward MA,Osborne DJ,Wishart G,Mathews KS,McLaughlin DP,Stamford JA,McCarty DR,Patrick KE,Roman C,Fleisch JH,Gilmore J,Boot JR

更新日期：2001-01-05 00:00:00

abstract：:In humans, tendon vibration evokes illusory sensations of movement that are usually associated with an excitatory tonic response in muscles antagonistic to those vibrated (antagonist vibratory response, AVR), i.e., in the muscle groups normally contracted if the illusory movement had been performed. The aim of the pre...

journal_title：Brain research

authors： Calvin-Figuière S,Romaiguère P,Roll JP

更新日期：2000-10-27 00:00:00

abstract：:The purpose of the current study is to investigate the functional connections between the central histaminergic and cholinergic systems at NTS level in hypotensive condition. Experiments were carried out in male Wistar Albino rats. The hypotension was achieved by withdrawing a total volume of 1.5ml blood/100g bodyweig...

journal_title：Brain research

authors： Altinbas B,Guvenc G,Erkan LG,Ilhan T,Niaz N,Yalcin M

更新日期：2016-10-15 00:00:00

abstract：:The effects of medial septal lesions on latent inhibition (LI) were assessed in a conditioned taste aversion paradigm. Animals were tested in a LI paradigm 2 weeks after receiving medial septal or sham lesions. The LI paradigm involved a pre-exposure phase in which water-deprived rats were allowed access to either wat...

journal_title：Brain research

authors： Turgeon SM,Kegel G,Davis MM

更新日期：2001-02-02 00:00:00

abstract：:Combined amylin+leptin (AMN+LEP) can reduce diet induced obesity and is very effective in combating LEP resistance. The purpose of this study was to evaluate the effect of AMN+LEP on central histaminergic signaling in lean and obese rats. Male rats were administered LEP (300 μg/kg/d), AMN (100 μg/kg/d), AMN+LEP or veh...

journal_title：Brain research

authors： Seth R,Terry DE,Parrish B,Bhatt R,Overton JM

更新日期：2012-03-09 00:00:00

abstract：:Effects of alpha-adrenoceptor agents on electrophysiologically and immunohistochemically identified supraoptic nucleus (SON) vasopressin (VP) units were investigated by intracarotid infusion. Clonidine, an alpha 2-adrenoceptor agonist always excited SON units and alpha 2-adrenoceptor antagonists consistently inhibited...

journal_title：Brain research

authors： Mitchell LD,Callahan MF,Wilkin LD,Johnson AK

更新日期：1986-12-10 00:00:00

abstract：:Cortical stimulation has been demonstrated to alleviate certain pain conditions. The aim of this study was to determine the responses of the spinal cord dorsal horn neurons to stimulation of the primary somatosensory cortex (SSC). We hypothesized that direct stimulation of the SSC will inhibit the activity of spinal d...

journal_title：Brain research

authors： Senapati AK,Huntington PJ,LaGraize SC,Wilson HD,Fuchs PN,Peng YB

更新日期：2005-09-28 00:00:00

abstract：:It is well known that the nerve growth factor (NGF) may serve as a link between inflammation and hyperalgesia. Recent experiments showed that systemic injection of NGF dramatically stimulated the expression of brain-derived neurotrophic factor (BDNF) mRNA in the dorsal root ganglion (DRG). In the present study, we eva...

journal_title：Brain research

authors： Cho HJ,Kim SY,Park MJ,Kim DS,Kim JK,Chu MY

更新日期：1997-02-28 00:00:00

abstract：:The rate and pattern of seizure development provoked by repeated electrical stimulation of the amygdala (kindling) was assessed in rats that had been pretreated with intracerebral injections of the selective catecholaminergic neurotoxin 6-hydroxy-dopamine. Rats with selective depletion of forebrain noradrenaline displ...

journal_title：Brain research

authors： Corcoran ME,Mason ST

更新日期：1980-05-26 00:00:00

abstract：:Transient ischemia increases tyrosine phosphorylation of N-methyl-D-aspartate (NMDA) receptor. Several tyrosine kinases are involved in this process. In this study, effect of ischemia and reperfusion (I/R) on tyrosine phosphorylation of NMDA receptor subunit 2A (NR2A) and the interaction of two tyrosine kinases, Src a...

journal_title：Brain research

authors： Liu Y,Zhang G,Gao C,Hou X

更新日期：2001-08-03 00:00:00

abstract：:Fibrates are activators of peroxisome proliferator-activated receptor (PPAR) α. Pretreatment with fibrates has been shown to protect brain against ischemia in mice. We hypothesized that fibrates elevate superoxide dismutase (SOD) levels in the brain microvessels (BMVs). BMVs were isolated from male C57BL/6 and PPARα n...

journal_title：Brain research

authors： Wang G,Liu X,Guo Q,Namura S

更新日期：2010-11-04 00:00:00

abstract：:Prenatal exposure to opiates, which is invariably followed by postnatal withdrawal, can affect cognitive performance. To further characterize these effects, we examined radial 8-arm maze performance and expression of brain derived neurotrophic factor (BDNF) in male rats prenatally exposed to the opiate l-alpha-acetylm...

journal_title：Brain research

authors： Schrott LM,Franklin L',Serrano PA

更新日期：2008-03-10 00:00:00

abstract：:The response of trunk neural crest cells taken from precise levels of the neural axis and cultured together with adjacent somites to Brain-derived neurotrophic factor (BDNF), was examined in cultures grown in a chemically defined medium. In control cultures, the number of neural crest-derived neurons expressing the HN...

journal_title：Brain research

authors： Kalcheim C,Gendreau M

更新日期：1988-06-01 00:00:00

abstract：:We investigated the effects of collagen II-induced arthritis on two cerebrospinal fluid (CSF) enzymes converting dynorphin A and substance P (SP), namely dynorphin-converting enzyme (DCE) and substance P endopeptidase (SPE). The products generated by these enzymes are the bioactive fragments Leu-enkephalin-Arg6 and su...

journal_title：Brain research

authors： Persson S,Post C,Holmdahl R,Nyberg F

更新日期：1992-05-29 00:00:00

abstract：:Proechimys, a rodent living in the Amazon region, has shown resistance to developing chronic epilepsy when submitted to different experimental models. Recently, many studies have attributed a potent anticonvulsant action to cannabinoid receptor CB1. This study investigated the distribution and expression of the CB1 re...

journal_title：Brain research

authors： Araujo BH,Torres LB,Cossa AC,Naffah-Mazzacoratti Mda G,Cavalheiro EA

更新日期：2010-06-04 00:00:00

abstract：:The effect of intracerebroventricular (i.c.v.) infusion of various iso- and hypertonic saccharide solutions on water intake stimulated by intracarotid (i.c.) infusion of hypertonic NaCl was studied in sheep. Without an i.c.v. infusion, water intake during a 10-min period following an i.c. infusion of 4 M NaCl (1.4 ml/...

journal_title：Brain research

authors： Park R,Denton DA,McKinley MJ,Pennington G,Weisinger RS

更新日期：1989-07-24 00:00:00

abstract：:Electrical stimulation of the mesencephalic locomotor region (MLR) in the precollicular-postmammillary transected cat is known to induce controlled locomotion on a treadmill. We have been able to induce and block locomotion in this preparation by using localized infusions of transmitters and their agonists and antagon...

journal_title：Brain research

authors： Garcia-Rill E,Skinner RD,Fitzgerald JA

更新日期：1985-03-18 00:00:00

abstract：:Single-electrode depth profiles of the hippocampal EEG were made in urethane-anesthetized rats and rats trained in an alternating running/drinking task. Current source density (CSD) was computed from the voltage as a function of depth. A problem inherent to AC-coupled profiles was eliminated by incorporating sustained...

journal_title：Brain research

authors： Brankack J,Stewart M,Fox SE

更新日期：1993-07-02 00:00:00

abstract：:Stress stimulates the adrenal medulla to rapidly secrete catecholamines (CAs), and the adrenal cortex to release progesterone (PROG), which may locally regulate stress-induced CA release. We used bovine chromaffin cells to investigate the effects of PROG on CA secretion. PROG dose-dependently inhibited CA secretion in...

journal_title：Brain research

authors： Armstrong SM,Stuenkel EL

更新日期：2005-05-10 00:00:00

abstract：:Intracellular recordings from CA3b/c neurons in rat hippocampal slices showed that reduction of the extracellular Cl- concentration from 136 to 53 mM produced a positive (+10 mV) shift in the reversal potential of GABAergic inhibitory postsynaptic potentials (IPSPs). This shift was not significantly different from the...

journal_title：Brain research

authors： Chamberlin NL,Dingledine R

更新日期：1988-03-29 00:00:00

abstract：:When rabbit retinas are exposed in vitro to specific excitatory amino acid receptor agonists certain GABAergic amacrine cells are activated to cause a release of GABA. The GABA that is not released can be detected by immunohistochemistry. Exposure of tissues to kainate or NMDA each caused a characteristic change in th...

journal_title：Brain research

authors： Osborne NN,Pergande G,Block F,Schwarz M

更新日期：1994-12-26 00:00:00

abstract：:The effects of systemically administered interleukin-1beta (1.0 microg) on in vivo variations of monoamines was assessed in several brain regions. Administration of the cytokine provoked a modest increase of extracellular 5-HIAA and HVA from the nucleus accumbens, and 5-HIAA from the hippocampus. Following mild neurog...

journal_title：Brain research

authors： Merali Z,Lacosta S,Anisman H

更新日期：1997-07-04 00:00:00

abstract：:We have recently characterized the histopathological changes in an experimental model of mesial temporal lobe epilepsy (MTLE) induced by the intrahippocampal injection of low dose of kainate in mice. Although cerebral metabolism and blood flow are extensively studied and used in human MTLE to locate the regions involv...

journal_title：Brain research

authors： Bouilleret V,Boyet S,Marescaux C,Nehlig A

更新日期：2000-01-10 00:00:00