Immunohistochemical evidence for flupirtine acting as an antagonist on the N-methyl-D-aspartate and homocysteic acid-induced release of GABA in the rabbit retina.

Abstract:

:When rabbit retinas are exposed in vitro to specific excitatory amino acid receptor agonists certain GABAergic amacrine cells are activated to cause a release of GABA. The GABA that is not released can be detected by immunohistochemistry. Exposure of tissues to kainate or NMDA each caused a characteristic change in the GABA immunoreactivity. CNQX antagonised the kainate effect specifically while MK-801 counteracted the influence of NMDA. The effect produced by kainate was mimicked by domoic acid while the influence of homocysteic acid was identical with NMDA. Flupirtine alone did not influence the nature of the GABA immunoreactivity and so did not act as a kainate or NMDA agonist. However, flupirtine counteracted the influence produced by NMDA and homocysteic acid but had no effect on the kainate and domoic acid responses. Thus in this system flupirtine acts as an NMDA antagonist.

journal_name

Brain Res

journal_title

Brain research

authors

Osborne NN,Pergande G,Block F,Schwarz M

doi

10.1016/0006-8993(94)91510-5

subject

Has Abstract

pub_date

1994-12-26 00:00:00

pages

291-4

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(94)91510-5

journal_volume

667

pub_type

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