Abstract:
:When rabbit retinas are exposed in vitro to specific excitatory amino acid receptor agonists certain GABAergic amacrine cells are activated to cause a release of GABA. The GABA that is not released can be detected by immunohistochemistry. Exposure of tissues to kainate or NMDA each caused a characteristic change in the GABA immunoreactivity. CNQX antagonised the kainate effect specifically while MK-801 counteracted the influence of NMDA. The effect produced by kainate was mimicked by domoic acid while the influence of homocysteic acid was identical with NMDA. Flupirtine alone did not influence the nature of the GABA immunoreactivity and so did not act as a kainate or NMDA agonist. However, flupirtine counteracted the influence produced by NMDA and homocysteic acid but had no effect on the kainate and domoic acid responses. Thus in this system flupirtine acts as an NMDA antagonist.
journal_name
Brain Resjournal_title
Brain researchauthors
Osborne NN,Pergande G,Block F,Schwarz Mdoi
10.1016/0006-8993(94)91510-5subject
Has Abstractpub_date
1994-12-26 00:00:00pages
291-4issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(94)91510-5journal_volume
667pub_type
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