Abstract：
:In this study, we aimed at investigating the effect of an enriched environment (EE) on the recovery from chronic inflammatory pain. Inflammatory pain was induced by the injection of 2 mg of carrageenan (CAR) into the right knee of male Sprague-Dawley rats (n=34). Rats were housed either singly (S-housed) or in an EE (EE-housed). The EE consisted of a large cage (L x W x H=2.0 x 1.0 x 0.8 m) containing various attributes (e.g. running wheels, shelter house, climbing frame). Withdrawal response to von Frey filament was used to assess mechanical allodynia at days post-operative (DPO) -1, 1, 7, 14, 21 and 28. S-housed animals showed a marked tactile sensitivity in the ipsilateral paw from DPO1 to DPO21. Four weeks after the CAR injection, S-housed rats were no longer allodynic. In contrast, EE-housed rats showed a significantly faster recovery: already at DPO21, they were no longer allodynic. In a first attempt to analyse the possible role of astroglial cells in the EE-induced effect, histological analysis at DPO21 was performed. Immunohistochemical staining of the spinal dorsal horn at L3-L5 indeed showed that spinal levels of astroglial activation are different between the two housing groups and therefore may play a role in the EE-induced effect on the duration of mechanical allodynia. In conclusion, our results showed that EE-housing results in a reduced duration of mechanical allodynia in chronic inflammatory pain in rats. Astroglial activation is suggested to be involved in this housing effect.
journal_name
Brain Resjournal_title
Brain researchauthors
Gabriel AF,Marcus MA,Honig WM,Helgers N,Joosten EAdoi
10.1016/j.brainres.2009.04.039subject
Has Abstractpub_date
2009-06-18 00:00:00pages
83-90eissn
0006-8993issn
1872-6240pii
S0006-8993(09)00821-Xjournal_volume
1276pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The selective dopaminergic antagonist ligands [3H]SCH 23390 and [3H]sulpiride were used to reveal autoradiographically dopamine D1 and D2 receptors, respectively, in brain sections from rats which had received unilateral 6-hydroxydopamine (6-OHDA) injections destroying ascending nigrostriatal neurones. The binding of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90439-i
更新日期：1990-04-23 00:00:00
abstract：:In the urethane-anesthetized rat both electrical stimulation (20 microA, 0.2 ms, 30 s) through micropipettes and glutamate injections (0.1 M, 100 nl) within an area including the dorsal lateral parabrachial nucleus, the adjacent central lateral parabrachial nucleus, the external lateral parabrachial nucleus, the Kölli...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90570-7
更新日期：1988-10-18 00:00:00
abstract：:Glioblastoma stem cells (GSCs) are thought to contribute to the diffuse invasiveness of malignant gliomas. Emerging evidence supports a role for a disintegrin and metalloproteinase 17 (ADAM17) in proteolytic ectodomain shedding of several EGFR-binding ligands, which subsequently activate PI3K/AKT and MEK/ERK pathways ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.02.025
更新日期：2013-11-13 00:00:00
abstract：:Multiple dose administration of methamphetamine (MA) results in long-lasting toxic effects in the nigrostriatal dopaminergic system. These effects are considered to be primarily due to oxidative damage mediated by increased production of hydrogen peroxide or other reactive oxygen species in the dopaminergic system. Th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02122-8
更新日期：1999-12-18 00:00:00
abstract：:We previously showed indirectly that the increase in diacylglycerol (DAG) levels caused by exposing differentiating PC12 cells to nerve growth factor (NGF) must derive mainly from de novo synthesis and, to a lesser and transient extent, from the hydrolysis of [3H]phosphatidylinositol (PI). To explore further the bioch...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01280-3
更新日期：1999-02-13 00:00:00
abstract：:Intraventricular injections of carbachol, a cholinergic agonist, into free-running mice can cause phase dependent phase shifts, in both directions, in the circadian rhythm of wheel-running activity. These effects mimic the action of light in entraining the circadian pacemaker, and suggest that acetylcholine may play a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90059-7
更新日期：1981-05-11 00:00:00
abstract：:The beneficial effects of angiotensin II type 1 (AT1) receptor blockers (ARB) in cerebrovascular disease have been shown in clinical trials. However, the effects of ARBs vary based on their unique pharmacologic properties. In this study, we focused on telmisartan, a fat-soluble ARB with selective peroxisome proliferat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.101
更新日期：2010-06-22 00:00:00
abstract：:The induction of gene expression has been correlated with long-lasting neuronal plasticity and long-term memory (LTM) formation. The fast activation of constitutive transcription factors by signaling mechanisms is thought to be the link between synaptic events and gene expression. However, only one constitutive transc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02358-6
更新日期：2000-02-14 00:00:00
abstract：:Within the framework of the dual process model of recognition memory, prior work with event-related potentials (ERPs) has suggested that an early component, the FN400, is a correlate of familiarity while a later component, the Late Positive Complex (LPC), is a correlate of recollection. However, other work has questio...
journal_title：Brain research
pub_type： 临床试验,杂志文章
doi：10.1016/j.brainres.2006.04.050
更新日期：2006-06-22 00:00:00
abstract：:This study attempted to ascertain whether heatstroke-induced ischemia is associated with augmented striatal glutamate release and can be attenuated by NMDA receptor antagonists. Mean arterial pressure (MAP), striatal cerebral blood flow (CBF), striatal glutamate release and striatal neuronal damage score were assessed...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00282-0
更新日期：1998-06-08 00:00:00
abstract：:Intracranial pressure (ICP) was monitored to evaluate the therapeutic effect of hyperbaric oxygen (HBO(2)) treatment following traumatic brain injury (TBI). This subject is controversial. The aim of our study was to determine whether HBO(2) treatment has a therapeutic effect on ICP dynamics and survival following seve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.02.049
更新日期：2005-06-21 00:00:00
abstract：:In the dorsal lateral geniculate nucleus (LGN) of the adult cat there is no evidence for translaminar sprouting of retinal axons to fill sites freed of retinal endings from the other eye. We tested the possibility that retinal axons will sprout to fill denervated retinal sites within laminae of the monkey LGN. In 4 mo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90721-1
更新日期：1977-05-06 00:00:00
abstract：:Ethylcholine aziridinium ion (AF64A) diluted in artificial perilymph, or artificial perilymph alone was infused into the cochlea of chinchillas. After a survival time of 7 days, the cochleas were fixed with aldehydes, post-fixed in osmium and embedded in epoxy resin for light and electron microscopy. The ultrastructur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90889-4
更新日期：1991-03-22 00:00:00
abstract：:Appetite suppressants lose efficacy when given chronically; the mechanisms are unknown. We gave male rats once-daily dl-fenfluramine (dl-FEN, 5 mg/kg, i.p.) injections for 15 days and measured mRNA expression of corticotropin releasing factor (CRF), neuropeptide Y (NPY) and proopiomelanocortin (POMC) in hypothalamic n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.129
更新日期：2006-05-04 00:00:00
abstract：:Chronic total sleep deprivation (TSD) of rats by the disk-over-water method reliably produces initial increases and subsequent decreases in waking intraperitoneal (Tip) and hypothalamic (Thy) temperatures, progressive increases in energy expenditure, skin lesions on the tail and plantar surfaces, debilitated appearanc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01071-8
更新日期：1995-12-12 00:00:00
abstract：:The binding of the adenosine receptor agonists, [3H]N-ethylcarboxamidoadenosine (NECA) and [3H]cyclohexyladenosine (CHA) to membrane preparations and to cryostat sections of the rat brain was examined. The xanthine derivative, 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) was ca. 500-fold more effective at A1 than at A2 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90589-5
更新日期：1986-03-19 00:00:00
abstract：:The choroid plexus (CP) performs the vital function of producing up to 90% (450-1000 ml/day) of cerebrospinal fluid (CSF) to nourish and to protect the brain in the CSF suspension. The CP also acts as a selective barrier between blood and CSF to regulate ions and other essential molecules. However, the accumulation of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01466-3
更新日期：1999-06-19 00:00:00
abstract：:Amyloid deposition, a histopathological feature of Alzheimer's disease brain, may be the underlying cause of this disease. The isolation of enzymes involved in both the normal and aberrant or alternative processing of the beta-amyloid precursor protein may lead to an understanding of how beta-protein, the major compon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91279-n
更新日期：1992-09-04 00:00:00
abstract：:Responsiveness of single inferotemporal (IT) neurons to a tone as a start or warning signal in each test trial was investigated in monkeys performing visual discrimination of 4 patterns. It was found that the same IT neurons were responsive to both auditory signal and visual discriminanda with different response chara...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(87)80031-8
更新日期：1987-04-28 00:00:00
abstract：:Recent evidence indicates that the superior colliculus (SC), in addition to its functions in sensory detection, also participates in controlling the generalized activation state of the forebrain, as measured by the electroencephalogram (EEG) or electrocorticogram (ECoG). The mechanisms by which the SC modulates forebr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04062-3
更新日期：2003-02-21 00:00:00
abstract：:Using a dual-serial-arithmetic paradigm, we examined whether a capacity limitation constrains the neural activation that underlies dual-task performance. Six conditions were run in the experiment (the baseline, single-addition, single-subtraction, dual-addition, dual-subtraction, and the dual-operation condition). In ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.12.070
更新日期：2008-03-14 00:00:00
abstract：:Little is known about the movement of 5-aminolevulinic acid (delta-aminolevulinic acid; ALA) between blood and brain. This is despite the fact that increases in brain ALA may be involved in generating the neuropsychiatric symptoms in porphyrias and that systemic administration of ALA is currently being used to delinea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03749-6
更新日期：2003-01-10 00:00:00
abstract：:Previous research has demonstrated that in the Siberian hamster, both photoperiod and estrous cyclicity alter the profile of noradrenergic activity with the paraventricular nucleus of the hypothalamus (PVN), and that noradrenergic activity is correlated with changes in circulating levels of prolactin. Work from our la...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.05.009
更新日期：2004-08-06 00:00:00
abstract：:The monoamine levels in the locus coeruleus (LC) were determined by HPLC following specific lesions of the ventral mesencephalic tegmental-A10 regions (VMT-A10) and raphé dorsalis (RD). Only lesions in the VMT-A10 area decreased the dopamine (DA) content, which strongly suggests that the projection from this region to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90327-x
更新日期：1983-03-21 00:00:00
abstract：:Frontal and temporal sections of 4 normal human brains and 3 brains from patients with a diagnosis of Alzheimer-type dementia (ATD) were stained with Vicia villosa lectin conjugated to biotin to localize glycoproteins containing terminal N-acetylgalactosamine. These lectin binding sites were localized at the surface o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90416-2
更新日期：1989-09-25 00:00:00
abstract：:Bilirubin, a product of haemoglobin metabolism, has been suggested to damage neurons by increasing activation of N-methyl-D-aspartate (NMDA) receptors when it reaches high levels in the blood [15,19], as occurs in neonatal jaundice [7]. Bilirubin is also generated in the brain following synthesis of the messenger carb...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02676-7
更新日期：2000-10-06 00:00:00
abstract：:Sustained seizure activity can be induced in rabbit olfactory bulb by application of brief low-level current via chronically implanted micro-electrodes. Sensitivity to such stimulation is markedly augmented by prior surgical isolation of the ipsilateral or contralateral bulb. The isolated rabbit olfactory bulb appar...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90056-6
更新日期：1975-08-29 00:00:00
abstract：:beta-Amyloid is the primary protein component of neuritic plaques, which are degenerative foci in brains of patients with Alzheimer's disease (AD). The effects of this naturally occurring beta-amyloid on the cells of the central nervous system have not been completely understood. beta-Amyloid increases the vulnerabili...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00043-7
更新日期：1997-04-18 00:00:00
abstract：:Brains of reptiles, Caiman crocodilus, were processed by standard immunocytochemical methodology using a polyclonal antibody to gamma-aminobutyric acid (GABA) raised in rabbit and a polyclonal antibody to glutamic acid decarboxylase (GAD) raised in sheep. No GABA(+) or GAD(+) cells or puncta were observed over any tha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90068-6
更新日期：1988-08-02 00:00:00
abstract：:Intracellular Ca2+, measured in NCB-20 cells with the fluorescent indicator fura-2, was elevated by K(+)-depolarization and by ethanol, but not by the excitatory amino acids L-glutamate and N-methyl-D-aspartate. These amino acids failed to raise intracellular Ca2+ levels even in the presence of elevated extracellular ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91639-i
更新日期：1991-01-25 00:00:00
