Abstract:
:The choroid plexus (CP) performs the vital function of producing up to 90% (450-1000 ml/day) of cerebrospinal fluid (CSF) to nourish and to protect the brain in the CSF suspension. The CP also acts as a selective barrier between blood and CSF to regulate ions and other essential molecules. However, the accumulation of intracellular inclusions called Biondi ring tangles (BRTs) in CP cells of Alzheimer's disease (AD)/aging brains may affect these vital functions of the CP. Statistical analysis of quantitative data on the numbers of CP cells containing BRTs from 54 brains (29 AD and 25 normal control), age range 1-100 years, indicated a significant difference (p<0.00004) between AD and control brains, using analysis of covariance (ANCOVA) with age as covariate. This study compiled the first set of archives to reveal the distribution pattern of BRTs in the CP of AD brains at various ages. Electron microscopy of negatively stained isolated BRTs revealed that these tangles are made of tightly packed bundles of long filaments with diameter around 10 nm that are morphologically distinct from the more loosely packed/shorter bundles of 6-8 nm amyloid fibrils of neuritic plaques (NPs) and from the 24 nm paired helical filaments of neurofibrillary tangles (NFTs) in AD brain. These data suggest that BRTs may represent a significant and measurable biomarker for AD in addition to NPs and NFTs.
journal_name
Brain Resjournal_title
Brain researchauthors
Wen GY,Wisniewski HM,Kascsak RJdoi
10.1016/s0006-8993(99)01466-3subject
Has Abstractpub_date
1999-06-19 00:00:00pages
40-6issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)01466-3journal_volume
832pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Evolutionary selection pressures have been one of the factors proposed to underlie sex differences in inhibitory control. Consequently, inhibitory control may vary as a function of the menstrual cycle and may be modulated by the stimuli being processed if these stimuli are related to reproductive success. We used func...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.05.061
更新日期:2008-08-11 00:00:00
abstract::We monitored biosynthetic activity of optic tract glia during regeneration of retinal ganglion cell axons in the goldfish and found that the greatest level of incorporated [3H]thymidine and [3H]leucine occurred in glia by 10-15 days after axotomy. During this period there was a marked increase in the number of oligode...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90624-9
更新日期:1985-07-22 00:00:00
abstract::In this study, we aimed at investigating the effect of an enriched environment (EE) on the recovery from chronic inflammatory pain. Inflammatory pain was induced by the injection of 2 mg of carrageenan (CAR) into the right knee of male Sprague-Dawley rats (n=34). Rats were housed either singly (S-housed) or in an EE (...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.04.039
更新日期:2009-06-18 00:00:00
abstract::The effect of anesthesia upon the functional outcome after experimental spinal cord injury (SCI) was studied in 221 rats subjected to graded weight drop contusion in the thoracic cord. Neurologic function was assessed in a blinded fashion for one week after injury using a modification of the method of Tarlov. The post...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91521-h
更新日期:1990-06-25 00:00:00
abstract::This study deals with the synaptology, morphologically identified postsynaptic targets, and origin of somatostatin (SOM) fibers in the rat lateral septal area (LSA) with special reference to those forming pericellular baskets. Septal vibratome sections were immunostained for SOM-14 in 3 experimental groups: control an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91743-k
更新日期:1991-11-22 00:00:00
abstract::Trials of neuroprotection in ischemic stroke mainly concern gray matter protection, with little information on white matter damage. Olfactory ensheathing cells (OECs) are capable of providing continuous neurotrophic factor and of promoting growth and remyelination of damaged axons. We evaluated OECs for the repair of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.12.061
更新日期:2010-03-04 00:00:00
abstract::The injured spinal cord does not heal properly. In contrast, tissue repair and functional recovery occur after skin or muscle injuries. The reason for this dichotomy in wound repair is unclear but inflammation, and specifically macrophage activation, likely plays a key role. Macrophages have the ability to promote the...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2014.12.045
更新日期:2015-09-04 00:00:00
abstract::Rabbits passively oscillated in the horizontal plane with a free hand tended to stabilize their head in space (re: earth-fixed surroundings) by moving the head on the trunk (neck angular deviation, NAD) opposite the passively imposed body rotation. The gain (NAD/body rotation) of head stabilization varied from 0.0 to ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90346-2
更新日期:1981-02-02 00:00:00
abstract::To characterize central nervous system changes that occur with anabolic steroid abuse in humans, immunocytochemical localization of androgen receptors in the brains of 10 intact and 10 castrated male rats was conducted after the administration of high levels of androgenic-anabolic steroids (AAS; 14 daily injections of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90823-6
更新日期:1993-09-17 00:00:00
abstract::We investigated the protective effects of minocycline following white matter damage (WMD) in the rat striatum. Excitotoxic lesions were induced by N-Methyl-d-Aspartate (NMDA) microinjections and caused striatal damage, concomitant with microglial/macrophage activation. The excitotoxic lesion both damaged oligodendrocy...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.03.007
更新日期:2010-05-06 00:00:00
abstract::The ability to ponder the future is a hallmark of human imagination. Neuroimaging research so far has focused on episodic prospection, or thinking about hypothetical future personal events. What has received no attention is semantic prospection or contemplating hypothetical future world events. Using functional magnet...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.07.084
更新日期:2008-10-03 00:00:00
abstract::The effects of glucose injection into the hepatic portal vein on neural activity of the lateral hypothalamic area (LHA) were studied in rats. A majority of identified glucose-sensitive neurons in the LHA were inhibited by portal injection of glucose. This was found to be mediated through the alpha-noradrenergic pathwa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91332-x
更新日期:1983-04-11 00:00:00
abstract::Kindling of the ventral tegmental area (VTA), a major source of the mesolimbic dopamine pathway, was examined in rats. We applied two quantitative measurements of dopamine sensitivity before and 2 weeks after VTA kindling (20 times electrical stimulations (100 microA at 1 min intervals) delivered once per day for 14 c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.01.006
更新日期:2004-04-02 00:00:00
abstract::The muscarinic cholinergic receptor of rat eccrine sweat gland was characterized using quantitative autoradiography and [3H]QNB as radioligand. The distribution of radioligand was maximal in the secretory coil. Autoradiographic competition binding studies were performed using selective antagonists to M1 (pirenzepine),...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90415-r
更新日期:1991-05-31 00:00:00
abstract::Choline is an essential nutrient whose availability during the second half of gestation produces long-lasting cognitive effects. Rats that obtain supplemental choline during embryonic day (E) 11-17 have enhanced depolarization-evoked acetylcholine (ACh) release from hippocampal slices, whereas choline deficiency durin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.08.046
更新日期:2008-10-27 00:00:00
abstract::The effects of forced swimming for 30 min on extracellular 5-hydroxytryptamine (5-HT) levels were examined in five brain regions in rats using in vivo microdialysis. A single dialysis probe was implanted under surgical anesthesia into either the striatum, ventral hippocampus, frontal cortex, amygdala, or lateral septu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00349-u
更新日期:1995-06-05 00:00:00
abstract::Adenosine and its agonists exert a depressant effect on neuronal activity by interacting with the adenosine A1 receptor. There is now also evidence for electrophysiological effects mediated by adenosine receptors other than the A1 type, possibly A2 receptors. A1 and A2 receptor-induced changes in the electrical proper...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91160-3
更新日期:1991-04-12 00:00:00
abstract::Anorexia nervosa is associated with vasopressin, oxytocin and serotonin abnormalities. Because of the relationship between exercise and anorexia nervosa, we explored the weight-loss syndrome produced by wheel running in food-deprived rats. Its effects on regional vasopressin and oxytocin concentrations were determined...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91659-g
更新日期:1993-05-28 00:00:00
abstract::Endogenous levels of salsolinol and dopamine were measured by a gas chromatography/mass spectrometry (GC/MS)--selected ion monitoring technique using deuterated internal standards in rats allowed to self-inject either acetaldehyde, ethanol or saline control solution over 20 days for 1 h/day. Significant increases in m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90955-2
更新日期:1985-12-09 00:00:00
abstract::Following codepletion of endogenous serotonin (5-HT, greater than 90%) and thyrotropin-releasing hormone (TRH, 66%) by neonatal treatment with the serotonergic neurotoxin, 5,7-dihydroxytryptamine (DHT), a 33% (n = 12, P less than 0.01) increase in specific TRH receptor binding was observed in adult rat spinal cord (SC...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90209-6
更新日期:1989-02-20 00:00:00
abstract::We sought to determine whether the global increase in regional cerebral blood flow (rCBF) produced by electrical stimulation of the rostral cerebellar fastigial nucleus (FN) is a consequence of excitation of intrinsic neurons of the FN or of axons of fibers passing through or projecting into it. Studies were conducted...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90312-0
更新日期:1989-10-23 00:00:00
abstract:BACKGROUND:It is unclear whether spinal cord stimulation (SCS) at higher frequencies induces further increases in vasodilation and enhances clinical efficacy. OBJECTIVES:This study investigated effects of SCS at both a normal frequency (as used clinically) and two higher frequencies on peripheral vasodilation. METHOD...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.11.072
更新日期:2010-02-08 00:00:00
abstract::We have sought to determine if changes in arterial and gastric pressure occurred with selective chemical stimulation of the dorsomedial NTS. Substance P (SP) and L-glutamate (L-glu), but not acetylcholine (ACh), elicited a dose-dependent decrease in tonic gastric pressure and inhibited gastric phasic activity. As prev...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91085-1
更新日期:1986-10-22 00:00:00
abstract::The bag cell neurons of Aplysia are capable of generating an afterdischarge, which, in vivo, triggers egg-laying behavior. Pharmacologic elevation of cyclic AMP levels in isolated bag cell neurons has been shown to initiate repetitive firming similar to that seen during an afterdischarge, and to decrease outward curre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91733-w
更新日期:1990-11-05 00:00:00
abstract::Peroxisome proliferator-activated receptor gamma (PPAR-gamma) has been described to have a role in the modulation of various genes involved in Abeta homeostasis, inflammation, and energy metabolism, making it a candidate gene for risk of Alzheimer's disease (AD). A functional polymorphism in exon 2 of the PPAR-gamma g...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.07.034
更新日期:2009-09-29 00:00:00
abstract::Indirect immunofluorescence cytochemistry of ovine corticotropin releasing factor (oCRF) was performed by use of an antiserum raised against a conjugate of oCRF and bovine thyroglobulin. The staining intensity was quantitated by use of an automated microfluorimeter. In cryostat sections of formaldehyde fixed oCRF cont...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91458-6
更新日期:1984-02-13 00:00:00
abstract::Slowness of goal-directed movements is a frequent symptom following cerebellar lesions. So far it has not been demonstrated whether this slowness represents compensation for impaired braking which is a feature of cerebellar dysfunction with the consequence of hypermetria, or whether it is an independent part of cerebe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01514-0
更新日期:1996-03-25 00:00:00
abstract::Projection neurons from the superior colliculus (SC) to the cuneiform region (CFR) of the midbrain form distinct cell clusters in the intermediate gray layer which precisely overlap the cholinergic fiber patches in this region of the cat SC (Jeon and Mize, J. Comp. Neurol., 337 (1993) 127-150). The acetylcholine (ACh)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00563-x
更新日期:1996-09-16 00:00:00
abstract::The content and turnover of dopamine, norepinephrine and 5-hydroxytryptamine (serotonin), and the content of their respective major metabolites were evaluated in 19 discrete brain areas of rats exposed to conditioned emotional response (CER), and in control groups which received either equivalent yoked shock (shock on...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90647-3
更新日期:1982-05-20 00:00:00
abstract::Intracerebral hemorrhage (ICH) is a devastating stroke often modelled in rats. Isoflurane anesthetic, commonly used in preclinical research, affects general physiology (e.g., blood pressure) and electrophysiology (e.g., burst suppression) in many ways. These physiological changes may detract from the clinical relevanc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.146593
更新日期:2020-02-01 00:00:00