Abstract：
:We investigated the protective effects of minocycline following white matter damage (WMD) in the rat striatum. Excitotoxic lesions were induced by N-Methyl-d-Aspartate (NMDA) microinjections and caused striatal damage, concomitant with microglial/macrophage activation. The excitotoxic lesion both damaged oligodendrocytes (Tau-1(+) cells) and caused a decrease in tissue reactivity for myelin basic protein (MBP) after post-lesional day 3 (PLD). Treatment with the semi-synthetic tetracycline antibiotic minocycline, however, led to oligodendrocyte preservation and decreased myelin impairment. Taken together, these results suggest that white matter damage (WMD) is an important component of the physiopathology of acute striatal damage and that microglial/macrophage activation contributes to this pathological phenomenon.
journal_name
Brain Resjournal_title
Brain researchauthors
Guimarães JS,Freire MA,Lima RR,Picanço-Diniz CW,Pereira A,Gomes-Leal Wdoi
10.1016/j.brainres.2010.03.007subject
Has Abstractpub_date
2010-05-06 00:00:00pages
182-93eissn
0006-8993issn
1872-6240pii
S0006-8993(10)00531-7journal_volume
1329pub_type
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