Abstract：
:We monitored biosynthetic activity of optic tract glia during regeneration of retinal ganglion cell axons in the goldfish and found that the greatest level of incorporated [3H]thymidine and [3H]leucine occurred in glia by 10-15 days after axotomy. During this period there was a marked increase in the number of oligodendroglia and multipotential glia near the site of injury with no change occurring in the astroglial population. Electron microscopic autoradiography showed that oligodendroglia and multipotential cells incorporated 5-7-fold more thymidine than did cells of intact control preparations. Though all glial cell types incorporated more [3H]leucine during axonal regeneration, oligodendroglia and multipotential cells together accounted for more than 90% of measured radioactivity. In order to characterize glial-stimulating events specific to axonal regeneration, we produced axonal degeneration in the optic tract by removal of the retina. Optic tract glia during axonal degeneration incorporated less amino acid when compared to glia associated with regenerating axons. The degenerating optic tract also had less 2',3'-cyclic nucleotide 3'-phosphohydrolase, an enzyme produced by oligodendroglia, than that found in the regenerating visual system. Our results suggest that in response to ganglion cell axotomy oligodendroglia and multipotential glia of the goldfish optic tract proliferate. Moreover, regenerating axons provide one type of stimulant for glial protein biosynthesis.
journal_name
Brain Resjournal_title
Brain researchauthors
Giulian D,Iwanij V,Stuckenbrok Hdoi
10.1016/0006-8993(85)90624-9subject
Has Abstractpub_date
1985-07-22 00:00:00pages
87-96issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(85)90624-9journal_volume
339pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The present study examines the brain-level representation and composition of meaning in scalar quantifiers (e.g., some), which have both a semantic meaning (at least one) and a pragmatic meaning (not all). We adopted a picture-sentence verification design to examine event-related potential (ERP) effects of reading inf...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.10.042
更新日期：2013-01-15 00:00:00
abstract：:Fifty-three cell pairs in the somatosensory cerebral cortex were examined in pentobarbital-anesthetized cats for evidence of short latency interactions. Many neuronal pairs separated by distances of 150 to 500 micron were observed to have temporal dependencies. In a subset of 19 pairs where the surrounding multiunit a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91479-9
更新日期：1985-08-19 00:00:00
abstract：:Visual-spatial working memory tasks can be decomposed into encoding and retrieval phases. It was hypothesized that encoding of visual-spatial information is cognitively more challenging than retrieval. This was tested by combining electroencephalography with a virtual reality paradigm to observe the modulation in EEG ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.086
更新日期：2010-08-06 00:00:00
abstract：:Horseradish peroxidase (HRP) injected into developing limb buds of Xenopus laevis tadpoles is carried by retrograde axonal transport to the somata of motoneurones in the ventral horn. Small injection of 10% HRP were found to remain well localised to specified sites in the limb bud. Two types of labelled cells were fou...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)91067-8
更新日期：1977-10-07 00:00:00
abstract：:Subtypes of muscarinic receptors were characterized in the frontal cortices of control and Alzheimer brains, with labelled quinuclidinyl benzilate [3H]QNB and the unlabelled muscarinic antagonists pirenzepine, AF-DX 116, hexahydro-sila-diphenidol (HHSiD), para-fluoro-hexahydro-sila-diphenidol (p-F-HHSiD) and himbacine...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91541-l
更新日期：1992-11-20 00:00:00
abstract：:The substantia nigra pars reticulata (SNr) receives both inhibitory GABAergic and excitatory glutamatergic afferents from diverse origins. Ischemic injury to the striatum and/or the globus pallidus causes delayed transneuronal death of the SNr neurons, in the course of which neuronal disinhibition induced by loss of G...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01052-9
更新日期：1996-12-16 00:00:00
abstract：:Estrogen has previously been shown to significantly change sympathetic and parasympathetic system output via an action within the central nuclei responsible for regulating autonomic tone. These estrogen-induced changes were observed within 30 min of systemic administration and could be blocked by the direct microinjec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03387-0
更新日期：2003-11-14 00:00:00
abstract：:The current study explored the effects of prolonged antidepressant treatment on mRNA levels of two nuclear receptors in specific brain regions of an animal model of depression, the Wistar-Kyoto (WKY) rat. Both nuclear receptors have been implicated in the development or treatment of depression. The expression of nucle...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.041
更新日期：2010-11-29 00:00:00
abstract：:Electrophysiological studies suggest that an increase in excitatory amino acid release may occur in the locus coeruleus during opiate withdrawal. The present study examined directly by microdialysis in anesthetized rats the effect of naltrexone-precipitated opiate withdrawal on the efflux of excitatory amino acids in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90186-4
更新日期：1994-02-04 00:00:00
abstract：:Previous reports from our laboratory have demonstrated that ethanol- and cannabinoid-induced ataxia is modulated by cerebellar adenosine A(1) receptor because intracerebellar (i.c.b.) adenosine A(1) agonists potentiated and A(1) antagonist attenuated ataxia by these psychoactive drugs. In this study, the novel approac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03599-0
更新日期：2002-12-06 00:00:00
abstract：:Brain-derived angiotensin II (ANG II) and prostaglandins have important roles in the regulation of body fluid and blood pressure homeostasis. In the present studies we investigated the central interactions between these two neurochemical products in regulating the hypothalamo-neurohypophysial system during dehydration...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03113-9
更新日期：2001-01-19 00:00:00
abstract：:Neuronal expression of brain-derived neurotrophic factor (BDNF) has been implicated in the mechanism of infarct tolerance (resistance to stroke) (H. Yanamoto et al., Infarct tolerance accompanied enhanced BDNF-like immunoreactivity in neuronal nuclei, submitted to Brain Res.), a process that takes more than 7 days fol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)01966-1
更新日期：2000-03-24 00:00:00
abstract：:Previous studies have observed that pial artery dilation to activators of the ATP sensitive K (K(ATP)) and calcium sensitive K (K(ca)) channel was blunted following fluid percussion brain injury (FPI) in the piglet. In recent studies in the rat, protein tyrosine kinase (PTK) activation was observed to contribute to K(...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02703-8
更新日期：2002-07-12 00:00:00
abstract：:Our previous studies have shown that there is a lower cGMP concentration in the aged brain as well as an alteration in the activity of cGMP-hydrolyzing phosphodiesterases (PDEs) and nitric oxide synthase (NOS). The aim of this study was to investigate the effect of specific inhibitors of selected PDEs on object recogn...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.108
更新日期：2008-06-24 00:00:00
abstract：BACKGROUND:Diminished dopaminergic neurotransmission contributes to decreased reward and negative eating behaviors in obesity. Bariatric surgery is the most effective therapy for obesity and rapidly reduces hunger and improves satiety through unknown mechanisms. We hypothesized that dopaminergic neurotransmission would...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.064
更新日期：2010-09-02 00:00:00
abstract：:Repetitive stimulation of an axon in the right visceropleural connective to the abdominal ganglion of Aplysia californica produces post-tetanic potentiation (PTP) of a unitary monosynaptic EPSP recorded from cell R15. PTP decays within one half hour following cessation of repatitive stimulation. Stimulation of the lef...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91262-7
更新日期：1980-01-06 00:00:00
abstract：:The divalent cation zinc has been reported to possess several physiological properties such as blocking apoptotic cell death through an inhibitory effect on Ca(2+)-Mg2+ endonuclease activity, or modulating the neurotoxicity via glutamate receptor subtypes. In the present study, we investigated the effect of peripheral...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01112-2
更新日期：1996-12-16 00:00:00
abstract：:Whole-cell voltage-clamp techniques were used to study the comparative effects of delta-9-tetrahydrocannabinol (THC) and its principal metabolite, 11-hydroxy-delta-9-tetrahydrocannabinol (11-OH-THC), on the voltage-gated sodium current in neuroblastoma cells. The parent compound markedly depressed the inward sodium cu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91239-w
更新日期：1991-09-27 00:00:00
abstract：:In this study we present data supporting a heterogeneous distribution of the brain-specific S-100 protein on nerve cell plasma membranes from isolated neurons. This has been shown in a previous study by immunoelectron microscopy using peroxidase-conjugated anti-S-100 antiserum and in this study by immunofluorescence u...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90161-4
更新日期：1975-12-26 00:00:00
abstract：:The ultrastructural localizations of rat corticoliberin (rCRF) and methionine-enkephalin octapeptide (Met-Enk-8) in the external layer of the rat median eminence were examined by double-immunogold labeling with anti-rCRF and anti-Met-Enk-8 sera labeled with small-sized (Gs) and medium-sized (Gm) gold particles, respec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90487-7
更新日期：1986-04-09 00:00:00
abstract：:We examined the effects of nicotinic drugs on the metabolites of [3H]dopamine (DA) released from rat striatal synaptosomes in comparison with the effects of high K+ and methamphetamine stimulation. The pattern of outflow of [3H]DA and its metabolites induced by nicotine stimulants, acetylcholine (ACh), nicotine and lo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90204-4
更新日期：1983-11-21 00:00:00
abstract：:While genetic predisposition is a major factor, it is not known how development of attention-deficit/hyperactivity disorder (ADHD) is modulated by early life stress. The spontaneously hypertensive rat (SHR) displays the behavioral characteristics of ADHD (poorly sustained attention, impulsivity, hyperactivity) and is ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.11.019
更新日期：2016-06-15 00:00:00
abstract：:Neuronal expression of c-fos product in the cat rostral ventrolateral medulla was studied by immunohistochemistry. Spinally projecting neurons of the subretrofacial (SRF) nucleus were pre-labeled by retrograde transport of fluorescent latex microspheres from the lumbar cord. In 3 animals which were bled by approximate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90099-u
更新日期：1992-03-20 00:00:00
abstract：:To determine the involvement of the hippocampal regions in a operant-type delayed alternation task of short delay or long delay, microinjections of muscimol into the hippocampus were used for temporal inactivation during the behavioral test in each rat. Dorsal hippocampal inactivation impaired the correct ratio of lon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02084-4
更新日期：2001-03-23 00:00:00
abstract：:The epileptogenic properties of the mast cell degranulating peptide (MCD) have been investigated in the CA3 region of the hippocampal slice preparation. Brief (3-5 min) bath application of MCD (0.5-2 microM) to CA3 hippocampal neurones produced an enhancement of the spontaneous synaptic activity and the appearance of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91077-3
更新日期：1988-03-29 00:00:00
abstract：:Using a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD), this study investigated on the neuroprotective effects of acupuncture by examining whether acupuncture contributed to inhibiting microglial activation and inflammatory events. C57BL/6 mice were treated with MPT...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.089
更新日期：2007-02-02 00:00:00
abstract：:A basic experiment of peripheral nerve regeneration using neuronal progenitor cells embedded in collagen gel was performed in a rat sciatic nerve defect. First, when neuronal progenitor cells derived from the fetal rat hippocampus were cultured in atelocollagen-containing medium, neurospheres positive for anti-nestin ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02539-3
更新日期：2003-06-06 00:00:00
abstract：:A startle-like response can be evoked at low currents by one-pulse electrical stimulation of reticular formation sites from the rostrolateral pons to the caudomedial medulla. To test whether this response is mediated by the same reticular formation neurons as those that mediate the acoustic startle, we delivered a bri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91100-7
更新日期：1993-07-23 00:00:00
abstract：:Immunohistochemical expression of the doublecortin (DCX) gene product was investigated in cerebral cortices from 33 normal developing human, aged 9 gestational weeks (GW) to 29 years, and from 26 patients with various neuronal migration disorders, aged 19 GW to 34 years. DCX immunoreactivity was detected predominantly...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02099-0
更新日期：2000-04-28 00:00:00
abstract：:We used in situ hybridization and immunocytochemistry to investigate the presence of GABA in neurons that express the type 3 serotonin receptor (5-HT3R). Quantitative analysis indicated that more than 90% of 5-HT3R expressing cells are GABAergic in the neocortex and hippocampus. The co-existence of 5-HT3R and GABA in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00557-4
更新日期：1996-08-26 00:00:00
