Abstract:
:Intracranial pressure (ICP) was monitored to evaluate the therapeutic effect of hyperbaric oxygen (HBO(2)) treatment following traumatic brain injury (TBI). This subject is controversial. The aim of our study was to determine whether HBO(2) treatment has a therapeutic effect on ICP dynamics and survival following severe fluid percussion brain injury (FPBI) in rats. Changes in ICP level were analyzed every 30 min during an 8-h monitoring period following trauma and at the end of experiment (20 h). The control (A) and experimental (B) groups consisted of 7 and 4 rats, respectively. Group B was subjected to 1.5 atmospheres absolute (ATA) 100% oxygen for 60 min beginning 2 h after FPBI. No significant differences in ICP were noted between groups A and B before and after HBO(2) treatment until 3.5 h after trauma. At 4 h, for the first time, the difference became significant (P = 0.025; n = 11) and remained significant (P < 0.05) for all measurement points until end of monitoring, when mean ICP values reached 37.17 +/- 14.25 and 20.25 +/- 2.63 mm Hg in groups A and B, respectively. Linear approximation models showed different trends (b1 = 3.80 +/- 0.23; r(2) = 0.65, P < 0.001 and b1 = 1.56 +/- 0.25; r(2) = 0.77, P < 0.001) for groups A and B, respectively. Covariance analysis confirmed significant differences between slopes for groups A and B (F = 148.04, P < 0.001; df = 2,177), i.e., a significant difference in mean rate of ICP elevation. By the end of the experiment, 3 out of 7 rats from group A had died, but none from group B. We conclude that the application of HBO(2) during the early phase of severe FPBI significantly diminished ICP elevation rate and decreased mortality level.
journal_name
Brain Resjournal_title
Brain researchauthors
Rogatsky GG,Kamenir Y,Mayevsky Adoi
10.1016/j.brainres.2005.02.049subject
Has Abstractpub_date
2005-06-21 00:00:00pages
131-6issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(05)00294-5journal_volume
1047pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Recent research has shown that familiarity contributes to associative memory when the to-be-associated stimuli are unitized during encoding. However, the specific processes underlying familiarity-based recognition of unitized representations are still indefinite. In this study, we present electrophysiologically dissoc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.08.089
更新日期:2010-11-11 00:00:00
abstract::We investigated the effect of losartan, a nonpeptide angiotensin II (Ang II)-type 1 (AT1) receptor antagonist, on the responses evoked by Ang II and L-glutamate (L-Glu) in the rostral ventrolateral medulla (RVLM). Adult spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were anesthetized with halothane ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91344-7
更新日期:1994-12-05 00:00:00
abstract::Existing data on the expression of H(4) histamine receptor in the CNS are conflicting and inconclusive. In this report, we present the results of experiments that were conducted in order to elucidate H(4) receptor expression and localization in the brain, spinal cord, and dorsal root ganglia (DRG). Here we show that t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.11.018
更新日期:2009-01-23 00:00:00
abstract::The effects of VIP and of peptides of the VIP family: secretin, glucagon, the porcine histidine isoleucine containing peptide (PHI) and the rat hypothalamic growth hormone-releasing hormone (rhGRF) on the cyclic AMP and inositol phosphate contents of isolated rat superior cervical ganglia were investigated. We demonst...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90200-3
更新日期:1986-06-25 00:00:00
abstract::Rats provided limited daily access to cocaine (1 h) maintain stable levels of drug self-administration over time while those switched to longer access (6 h or more) exhibit escalating patterns of drug intake. These results are reminiscent of human recreational and compulsive drug-taking behavior, respectively. We foun...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.09.053
更新日期:2004-01-02 00:00:00
abstract::Seven days after adrenalectomy (ADX) the number of vasoactive intestinal peptide (VIP)- and corticotropin-releasing factor (CRF)-immunoreactive cells in the parvocellular part of the rat paraventricular nucleus (PVN) increased markedly. Dexamethasone in the drinking water (started immediately after ADX) or its local i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91272-i
更新日期:1990-01-08 00:00:00
abstract::In the electrophysiologic test of the hindlimb withdrawal reflex where the long latency component is found to be dependent on noradrenaline (NA), implants of fetal NA tissue in lesioned animals result in a recovery of NA dependent function proportional to the number of catecholamine fluorescent cells in the implants. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90396-s
更新日期:1990-02-05 00:00:00
abstract::Axotomy produced an increase in the spike width and a decrease in amplitude of the afterhyperpolarization which followed the action potential in C-cells of bullfrog sympathetic ganglia. Although no change in B-cell conduction velocity was noted, C-cell conduction velocity increased significantly and approached that of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(87)80044-6
更新日期:1987-04-28 00:00:00
abstract::We sought to further elucidate signal transduction pathways for the I(1)-imidazoline receptor in PC12 cells and their interaction with the well-characterized signaling events triggered by nerve growth factor (NGF) in these cells. Stimulation of the I(1)-imidazoline receptor with moxonidine, a centrally acting antihype...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02893-2
更新日期:2003-08-01 00:00:00
abstract::Migraine headache is proposed to be mediated by nitric oxide (NO). Suitable mechanisms for eliciting increases in brain NO concentration in migraineurs have not yet been identified, although, animal models highlight cortical spreading depression (CSD) as a potential candidate. These studies have focused on CSD-associa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03191-7
更新日期:2001-02-09 00:00:00
abstract::Electrical stimulation of the dorsal hippocampal formation of the rat was employed to determine the effect of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3), the hormonal form of vitamin D, on induced seizure thresholds. Stereotaxic injection of 100 micrograms or 50 micrograms 1,25-dihydroxyvitamin D3 in 2 microliter propyle...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91153-3
更新日期:1984-04-23 00:00:00
abstract::Effects of hypothalamic stimulation (HS) were studied in intracellular recordings obtained from 125 neurons of the motor cortex (MC). HS that was effective in reinforcing bar-press behavior, i.e. satisfactory for intracranial self-stimulation (ICSS), evoked short-latency (less than 3 ms) activation of these cortical n...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91458-8
更新日期:1988-01-26 00:00:00
abstract::Nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) containing fibers and neurons within the hippocampal formation and entorhinal cortex of the new world monkey were determined using a direct histochemical procedure. Occasional intensely stained bipolar NADPH-d positive neurons were seen in the polymorphi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90924-z
更新日期:1990-05-21 00:00:00
abstract::Discharges of neurons in the midpontine dorsal tegmental field (DTF neurons) were recorded and analyzed during locomotion and were compared with those of reticulospinal neurons (RS neurons) located lateral to the DTF area. The conduction velocity of the descending axon of the DTF neurons was significantly smaller than...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91078-9
更新日期:1985-08-26 00:00:00
abstract::Quantitative [125I]protein G-based immunohistochemistry was used to map the distribution of beta1 thyroid hormone receptor (TRbeta1) in normal and thyroidectomized adult rat brain, using a previously characterized polyclonal antibody. The distribution of TRbeta1-like immunoreactivity in normal brain was largely but no...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00450-2
更新日期:1997-06-27 00:00:00
abstract::Intracerebroventricular administration of 10--20 microgram of steroid-O-sulfates induced hypermotility, agitation, salivation, EEG abnormalities, stereotypies, wet dog shakes and seizures. Equivalent effects resulted from 30--200 microgram morphine sulfate (H2SO4 salt), 50 microgram EGTA or 300--400 microgram of sodiu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90426-8
更新日期:1979-01-12 00:00:00
abstract::This study examined the involvement of N-methyl-D-aspartate receptors (NMDARs) in experience-dependent synaptic plasticity. Rats chronically received an NMDA receptor antagonist (AP5) or saline (SAL) and were exposed to individual cages (IC) or environmental enrichment (EC). AP5 impaired measures of hippocampal-depend...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02379-9
更新日期:2000-07-14 00:00:00
abstract::The development of bombesin-like peptides and their receptors was determined in 9 different rat brain regions. The concentration of immunoreactive bombesin increased dramatically in all brain regions examined during the third week after birth. In contrast, the density of [125I-Tyr4]bombesin binding sites was near maxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90107-x
更新日期:1984-08-01 00:00:00
abstract::The neocortex in chronically prepared rats is very resistant to the induction of long-term potentiation (LTP). In the first of two experiments described in this paper, we tried unsuccessfully to induce neocortical LTP within one session by coactivating basal forebrain cholinergic and cortical inputs to our neocortical...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01025-0
更新日期:1995-12-08 00:00:00
abstract::The quantitative 2-[14C]deoxyglucose autoradiographic method was used to study the effects of the acute administration of a sedative anticonvulsant dose of diazepam (2 mg/kg) on rat brain energy metabolism. This benzodiazepine was injected to rats chronically treated for two weeks either by caffeine (10 mg/kg/day) or ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90593-2
更新日期:1987-09-01 00:00:00
abstract::Dysfunction in the hypothalamic GABAergic system has been implicated in panic syndrome in humans. Furthermore, several studies have implicated the hypothalamus in the elaboration of pain modulation. Panic-prone states are able to be experimentally induced in laboratory animals to study this phenomenon. The aim of the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.09.096
更新日期:2009-12-11 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is characterized by a progressive degeneration of upper and lower motor neurons, resulting in fatal paralysis due to denervation of the muscle. Due to genetic, pathological and symptomatic overlap, ALS is now considered a spectrum disease together with frontotemporal dementia (FTD),...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2018.02.011
更新日期:2018-08-15 00:00:00
abstract::Rats with bilateral striatal cholinergic lesions induced by the neurotoxin AF64A were found to have increased spontaneous nocturnal locomotor activity as measured in terms of the amount of time spent moving, the total distance traveled and the number of episodes and time of stereotypic behaviors. No significant differ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90715-7
更新日期:1984-05-14 00:00:00
abstract::Glycine is thought to be a major inhibitory neurotransmitter in the mammalian CNS. Two types of physiologically identified interneurons, Renshaw cells and Ia inhibitory interneurons, were intracellularly stained with horseradish peroxidase, and their axon terminals were studied at the electron microscopic level. Post-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90590-r
更新日期:1991-04-26 00:00:00
abstract::The firing rate of the neurons of the hypothalamic paraventricular nucleus, the temperatures of the interscapular brown adipose tissue and of the colon (TIBAT and Tc) were monitored in 24 urethane-anesthetized male Sprague-Dawley rats divided into four groups. These variables were measured before and after hippocampal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01227-5
更新日期:1999-04-03 00:00:00
abstract::Parkinson's disease is characterized by a progressive loss of dopaminergic neurons, likely associated with dysregulation of oxidation of catechols, such as dopamine (DA) and 6-hydroxydopamine (6-OHDA), and resulting in oxidative stress. The involvement of cyclooxygenase-2 (COX-2) in pathogenesis of Parkinson's disease...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.10.105
更新日期:2006-06-06 00:00:00
abstract::A series of ballistic, unidirectional arm movements were studied to evaluate the electromyographic (EMG) and neuromuscular force patterns that occur when a limb is unexpectedly perturbed. Multiple training trials were continued with a control load spring attached to the apparatus until a pre-specified criterion for le...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90741-3
更新日期:1985-09-23 00:00:00
abstract::In anesthetized cats, medial gastrocnemius motor units (MUs) were electrically stimulated via their ventral-root axons with independent random patterns. Muscle tension and homonymous alpha-motoneuron (alpha-MN) membrane potential fluctuations in response to these stimuli were recorded simultaneously. Cross-correlating...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90763-2
更新日期:1985-09-23 00:00:00
abstract::We have previously raised a monoclonal antibody (69A1) which recognises a cell-surface antigen expressed on rat cerebellar neurons both in culture and in tissue sections of the developing cerebellum prior to postnatal day 17. In our current study we have undertaken a detailed analysis of the loss of labelling from the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(86)90087-8
更新日期:1986-09-01 00:00:00
abstract::Adult Long-Evans female rats sustained electrolytic fimbria-fornix lesions and, two weeks later, received intrahippocampal suspension grafts of fetal septal tissue. Sham-operated and lesion-only rats served as controls. Between 6.5 and 8 months after grafting, both the [3H]choline accumulation and the electrically evo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01092-0
更新日期:1995-12-18 00:00:00