Abstract：
:Existing data on the expression of H(4) histamine receptor in the CNS are conflicting and inconclusive. In this report, we present the results of experiments that were conducted in order to elucidate H(4) receptor expression and localization in the brain, spinal cord, and dorsal root ganglia (DRG). Here we show that transcripts of H(4) receptor are present in all analyzed regions of the human CNS, including spinal cord, hippocampus, cortex, thalamus and amygdala, with the highest levels of H(4) mRNA detected in the spinal cord. In rat, H(4) mRNA was detected in cortex, cerebellum, brainstem, amygdala, thalamus and striatum. Very low levels of H(4) mRNA were detected in hypothalamus, and no H(4) signal was detected in the rat hippocampus. Fairly low levels of H(4) mRNA were detected in examined peripheral tissues including spleen and liver. Interestingly, strong expression of H(4) mRNA was detected in the rat DRG and spinal cord. Immunohistochemical analysis revealed expression of H(4) receptors on neurons in the rat lumbar DRG and in the lumbar spinal cord. Our observations provide evidence of the H(4) presence in both human and rodent CNS and offer some insight into possible role of H(4) in itch and pain.
journal_name
Brain Resjournal_title
Brain researchauthors
Strakhova MI,Nikkel AL,Manelli AM,Hsieh GC,Esbenshade TA,Brioni JD,Bitner RSdoi
10.1016/j.brainres.2008.11.018subject
Has Abstractpub_date
2009-01-23 00:00:00pages
41-8eissn
0006-8993issn
1872-6240pii
S0006-8993(08)02729-7journal_volume
1250pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The glutamate analogue 2-amino-4-phosphonobutyric acid (AP4) is a potent antagonist at several synapses where an excitatory amino acid appears to be the neurotransmitter. Previous studies identified a Cl-/Ca2+ dependent [3H]glutamate binding site in synaptic plasma membrane (SPM) preparations that was also labeled by ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90977-7
更新日期：1986-06-04 00:00:00
abstract：:Gonadotropin-releasing hormone (GnRH) is a major neural signal for hypothalamic control of gonadotropin secretion which in turn influences gonadal steroid synthesis. Progesterone (P) is known to affect release and content of GnRH. The action mechanism of P on GnRH mRNA level remains, however, to be resolved. Here we r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90336-0
更新日期：1994-07-25 00:00:00
abstract：:Problems in interpretation of autoradiograms generated by ligand binding in brain tissue may be caused by two types of technical limitations: the differential absorption of 3H-generated emissions within the tissue (differential quenching) and the reduced resolution when 125I and 14C are used as isotopes. In the course...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90290-9
更新日期：1988-08-30 00:00:00
abstract：:The interaction of glutamatergic and dopamine neurotransmission is thought to have relevance to both the pathophysiology and pharmacotherapy of schizophrenia. For example, subanesthetic doses of the N-methyl-D-aspartate receptor (NMDA-R) antagonist ketamine induce schizophrenia-like behavioral effects in humans and bo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)01991-6
更新日期：2001-03-16 00:00:00
abstract：:In rats under urethane, iontophoretic applications of GABA (30-60 nA) in the str. pyramidale of CA1, showed a rapidly fading inhibitory effect. By contrast, GABA had a well-maintained inhibitory effect in str. radiatum. During iontophoresis of nipecotic acid (30-85 nA) identical applications of GABA in str. pyramidale...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91309-0
更新日期：1986-02-26 00:00:00
abstract：:The present paper addresses the question of whether a decline of central noradrenergic activity is associated with aging and memory loss in mice. Receptor binding techniques were utilized to compare alpha 2-adrenoceptor density in the brains of aged and young mice. Using [3H]rauwolscine, a selective alpha 2-adrenocept...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91439-8
更新日期：1985-12-16 00:00:00
abstract：:There is evidence that D1 and D2 dopamine receptor subtypes coexist at the cellular level in the striatum and act synergistically to mediate the effects of dopamine. Other data suggest that these receptor subtypes are largely segregated in different striatal projection pathways. We used in situ hybridization in serial...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90303-5
更新日期：1993-09-03 00:00:00
abstract：:Extracellular recordings were made from a type of relay neurons of the superior laryngeal nerve (SLN) afferents in the vicinity of the retrofacial nucleus (RFN) in either pentobarbitone-anesthetized or unanesthetized and decerebrate cats, which were paralyzed and artificially ventilated. A total of 26 neurons that cou...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91156-m
更新日期：1993-12-31 00:00:00
abstract：:Male Long-Evans rats were administered nicotine bitartrate or sodium tartrate either during adolescence (p29-43) or adulthood (p80-94). Route of administration was via subcutaneously implanted osmotic pump (initial dose 2.0 mg/kg/day, free base). Five weeks following nicotine administration, brains were processed for ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.019
更新日期：2007-06-02 00:00:00
abstract：:Previous studies in piglets show that opioid-induced pial artery dilation was impaired following fluid percussion brain injury (FPI). This study was designed to determine the role of the newly described opioid nociceptin orphanin FQ (NOC/oFQ) in such impaired dilation to other opioids after FPI. CSF NOC/oFQ concentrat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02367-2
更新日期：2000-06-30 00:00:00
abstract：:Homogenates of rat ventral and dorsal spinal cords were subjected to differential and gradient centrifugation on linear sucrose gradients following lysis of a synaptosomal fraction. The distribution of calcitonin gene-related peptide (CGRP) and substance P (SP) in dorsal spinal cord as well as the distribution of sero...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90780-4
更新日期：1989-10-16 00:00:00
abstract：:The onset of the daily wheel running bout precedes dark onset by several hours in the early runner genetic variant of mice. Here, we test the hypothesis that timed daily administration of a melatonin agonist, ramelteon, or a benzodiazepine, triazolam, normalizes the timing of daily wheel-running rhythms in early runne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.103
更新日期：2009-11-03 00:00:00
abstract：:An extensive exploration of the discriminating properties of olfactory receptors cells has been conducted in our laboratory through the statistical processing of single cell responses recorded in the frog's olfactory epithelium. Similarities between odorant stimulating properties could be demonstrated by comparing the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90764-9
更新日期：1984-02-06 00:00:00
abstract：:A quantitative freeze-fracture study of perivascular astrocytic processes in rat cerebral cortex disclosed rapid disintegration of orthogonal arrays of the intramembrane particles in acute global ischemia. The process apparently preceded the development of astrocytic swelling. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91348-9
更新日期：1984-05-21 00:00:00
abstract：:Habituation kinetics were found to vary considerably in different polysynaptic pathways of the brain stem in man. The exteroceptive reflex of the digastric muscle habituates markedly, even for stimuli repeated at 1-min intervals. The second component of the blink reflex habituates for intervals below about 8 sec, but ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90070-6
更新日期：1976-04-16 00:00:00
abstract：:The influence of glutamate and aspartate on the time course of decay of excitatory currents at neuromuscular junctions of locust skeletal muscle was examined. Both aspartate (up to 10 mM) and glutamate (up to 0.3 mM) had little influence on the decay time of the synaptic currents, whether measured intracellularly by v...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91020-3
更新日期：1980-06-16 00:00:00
abstract：:Intracellular Neurobiotin-injections were used to label functionally identified neurons in the rostro-dorsomedial part of the trigeminal oral nucleus (Vo.r) in the cat. The labeled Vo.r neurons with the mechanoreceptive field in oral tissues innervated bilaterally either jaw-opening motoneurons or jaw-closing motoneur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.12.042
更新日期：2005-03-02 00:00:00
abstract：:The intent of this study was to investigate neurochemical and behavioural effects of aversive stimulation and the impact of auditory background noise. Using in vivo microdialysis, hippocampal acetylcholine was extracted and subjected to HPLC analysis while male Wistar rats were exposed to aversive stimulation similar ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02842-0
更新日期：2000-11-03 00:00:00
abstract：:Increases in concentration of brain NO are proposed to initiate and mediate migraine headache. Triggered by focal depolarisation, spreading depression (SD) represents a suitable mechanism for eliciting widespread release of nitric oxide. The current study examines the effect of sumatriptan, a 5-HT(1B/1D) agonist and e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02400-8
更新日期：2000-07-07 00:00:00
abstract：:The neuropathological consequences of acute exposure to the neurotoxicants ammonia and octanoic acid were investigated with the isolated, perfused canine brain preparation. After 1 h of combined hyperammonemia and octanoic acidemia, ultrastructural changes were apparent in all brain regions examined. The cell bodies o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90916-3
更新日期：1985-08-12 00:00:00
abstract：:Murine brain cells differentiated for 19 days in culture before treatment for 5 days with 10 microM diazepam. Radioligand binding to the benzodiazepine receptors on membranes obtained from these cultures was determined by the filtration assay method. Decreased binding was observed in the membranes from treated culture...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90117-8
更新日期：1983-12-12 00:00:00
abstract：:Melatonin is synthesized rhythmically under control of circadian oscillators by the retinas of non-mammalian vertebrates. Here we report that the retinas of some strains of laboratory mice exhibit robust circadian rhythms of melatonin synthesis which can be entrained by light in vitro. The rd mutation results in progr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01446-7
更新日期：1998-04-13 00:00:00
abstract：:Sensitisation to the behavioural effects of amphetamine, a phenomenon which appears to involve the potentiation of excitatory amino acid (EAA)-mediated transmission at the level of dopaminergic (DA) neurons in the ventral tegmental area (the A10 cell group), is known to be affected by corticosteroid manipulations. Sin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00722-6
更新日期：1996-10-21 00:00:00
abstract：:Quantitative autoradiography was used to analyze cholecystokinin receptor (CCK-R) binding in the ventromedial hypothalamic nucleus (VMH) of gonadectomized rats treated with estrogen or testosterone. In the rostral VMH, sex steroids did not affect binding levels. In the caudal VMH, in both gonadectomized male and femal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01561-2
更新日期：1996-03-18 00:00:00
abstract：:Headache medicine is primarily dependent on patients' subjective reports of pain, which are assessed at diagnosis and throughout the duration of treatment. There is a need for an objective, quantitative biological measurement of headache pain severity. In this study, quantitative sensory testing (QST) was conducted vi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.12.043
更新日期：2013-03-01 00:00:00
abstract：:The effect of intraocular injection of the neurotoxin, kainic acid, on the retinofugal pathway has been examined by anterograde transport of horseradish peroxidase. Although less peroxidase was present in all the primary optic centers after the intraocular injection of kainic acid than in the controls, the area occupi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90939-9
更新日期：1984-01-09 00:00:00
abstract：:The onset of adult hypothyroidism causes neuronal damage in the CA3 hippocampal region, which is attenuated by T(4) administration. We analyzed the expression of molecular proliferation markers (Cyclin D1 and PCNA), cellular damage-arrest (p53 and p21), and apoptosis (Bax/Bcl-2 index) in the hippocampus of hypothyroid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.02.043
更新日期：2009-05-19 00:00:00
abstract：:Bone marrow-derived mesenchymal stem cells (BMSCs) are a promising source for cell-based treatment of brain injury, but the therapy of BMSCs is restricted by low cell survival. We examined whether nerve growth factor (NGF) improve BMSCs viability in the brain with Fimbria-Fornix lesion (FF). After transduction of NGF ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.01.010
更新日期：2009-01-19 00:00:00
abstract：:To evaluate roles of the sympathetic nervous system in enhancing glucose uptake in skeletal muscles in response to electrical stimulation of the ventromedial hypothalamic nucleus (VMH), the effects of guanethidine treatment and adrenal demedullation on the response were examined in rats anesthetized and injected with ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91085-5
更新日期：1994-06-27 00:00:00
abstract：:In this study, we aimed at investigating the effect of an enriched environment (EE) on the recovery from chronic inflammatory pain. Inflammatory pain was induced by the injection of 2 mg of carrageenan (CAR) into the right knee of male Sprague-Dawley rats (n=34). Rats were housed either singly (S-housed) or in an EE (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.04.039
更新日期：2009-06-18 00:00:00
