Abstract：
:Effects of hypothalamic stimulation (HS) were studied in intracellular recordings obtained from 125 neurons of the motor cortex (MC). HS that was effective in reinforcing bar-press behavior, i.e. satisfactory for intracranial self-stimulation (ICSS), evoked short-latency (less than 3 ms) activation of these cortical neurons more frequently (42% of cells tested) than did HS that was ineffective in reinforcing bar-press behavior (7% of cells tested). Longer latency activation (greater than 3 ms) and inhibition (of variable onset) also occurred, but their incidence was not significantly different when HS was effective or ineffective in producing ICSS. Effects of HS that was effective in producing ICSS were also examined in 23 cells in which the spikes were followed by afterhyperpolarization (AHP) of 1.4-10 mV amplitude and 1.7-54 ms duration. The amplitudes of AHPs of greater than 8 ms duration were reduced after presentations of HSs that were effective as a reinforcer for ICSS. These results suggest that: (1) MC neurons receive reward-related hypothalamic information through pathways sufficiently direct to produce short-latency activation; and (2) a modulation of spike afterhyperpolarization can be observed in conjunction with reception of this information.
journal_name
Brain Resjournal_title
Brain researchauthors
Aou S,Oomura Y,Woody CD,Nishino Hdoi
10.1016/0006-8993(88)91458-8subject
Has Abstractpub_date
1988-01-26 00:00:00pages
31-8issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(88)91458-8journal_volume
439pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The aim of this investigation was to determine whether an ingredient of green tea, epigallocatechin gallate (EGCG) could attenuate oxidative stress-induced degeneration of the retina as occurs in age-related macular degeneration (AMD) and glaucoma. Initial in vitro studies on brain membranes showed that EGCG was appro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.09.067
更新日期：2006-12-08 00:00:00
abstract：:Previous immunocytochemical studies have shown immunological differences between neurofilaments in axons and those in dendrites and perikarya of many mature neuron types: it is now known that non-phosphorylated epitopes are normally seen in cell bodies and dendrites of mature neurons, whereas phosphorylated epitopes a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90367-8
更新日期：1988-09-20 00:00:00
abstract：:Mouse VD-hemopressin(α) (VD-Hpα) is an undecapeptide that selectively activates CB1 cannabinoid receptor in in vitro functional tests, and exerts CB1-mediated central antinociception in the mouse tail-flick assay. The aim of the present study was to further investigate the analgesic properties of supraspinal mouse VD-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.12.013
更新日期：2018-02-01 00:00:00
abstract：:Acute and repeated exposure to cocaine induces long-lasting alterations in neural networks that underlie compulsive drug seeking and taking. Cocaine exposure triggers complex adaptations in the brain that are mediated by dynamic patterns of gene expression that are translated into enduring changes. Recently, epigeneti...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2014.09.069
更新日期：2015-12-02 00:00:00
abstract：:Previous studies on the processing of fractions and proportions focused mainly on the processing of their overall magnitude information in the intraparietal sulcus (IPS). However, the IPS is also associated with domain-general cognitive functions beyond processing overall magnitude, which may nevertheless be involved ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.02.029
更新日期：2019-07-01 00:00:00
abstract：:Treatment of castrated quail with testosterone (T) reliably activates male copulatory behavior and, at the same time, increases the aromatase activity (AA), the number of aromatase-immunoreactive (ARO-ir) cells and the concentration of aromatase mRNA as measured by RT-PCR in the brain. All these effects can be mimicke...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01008-0
更新日期：1995-12-01 00:00:00
abstract：:There is a sizeable literature concerning basal ganglia (BG) functioning that is based on data from experiments employing a method of analysis that is traditionally used with other motor areas. A brief review of this literature is presented and the following conclusion is reached: as compared to the success of traditi...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/0165-0173(85)90010-4
更新日期：1985-06-01 00:00:00
abstract：:Endogenous opioid systems (i.e. opioids and opioid receptors) play a role in regulating neural development. Using the cerebellar cortex of 6-day-old rats, the most potent opioid peptides involved with cell proliferation were assessed. In both the external germinal (granule) layer (EGL), a germinative matrix giving ris...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91585-o
更新日期：1991-03-01 00:00:00
abstract：:We measured the effect of high PCO (500-550 Torr) on the pHi and [Ca2+]i in cultured glomus cells of adult rat carotid body (CB) as a test of the two models currently proposed for the mechanism of CB chemoreception. The metabolic model postulates that the rise in glomus cell [Ca2+]i, the initiating reaction in the sig...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00607-6
更新日期：1998-08-24 00:00:00
abstract：:Temporo-nasal asymmetry in visual responses has been observed in many behavioural studies. These observations have typically been attributed to the anatomical asymmetry of fibres projecting to the Superior Colliculus (SC), even though this attribution is debated. The present study investigates temporo-nasal asymmetry ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.03.087
更新日期：2008-11-25 00:00:00
abstract：:Neuropeptide Y (NPY) has been detected immunocytochemically in cerebral cortex and subcortical white matter of the primate frontal, parietal, temporal, and occipital lobes. Because little is known about NPY in the primate insular lobe and because peptides play an important role in normal neuronal functioning and alter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91245-n
更新日期：1993-02-19 00:00:00
abstract：:Neurons immunoreactive for the calcium-binding protein calretinin (CR) were visualized in the substantia nigra (SN) pars compacta (SNc), reticulata (SNr) and lateralis (SNl), the ventral tegmental area (VTA) and the subthalamic nucleus (STN) of squirrel monkeys. The density of CR perikarya was high in VTA, moderate in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01374-1
更新日期：1996-02-05 00:00:00
abstract：:Generalized barrel-rolling convulsions and focal hypermetabolic responses in the cerebellar cortex of conscious rats to lateral ventricular injection of the neuropeptide, endothelin-1 (ET; 9 pmol), were diminished or eliminated by i.c.v. pretreatment with the glutamatergic NMDA receptor antagonist, MK-801 (44 nmol). U...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91334-x
更新日期：1994-06-06 00:00:00
abstract：:Spontaneous hippocampal EEG activity and evoked field potentials were investigated in intact rats and in animals with fetal hippocampal grafts. Pieces of hippocampal grafts, derived from 15- to 16-day-old fetuses, were used to prepare cell suspensions and grafted directly into the intact hippocampus. Control animals r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90168-u
更新日期：1991-07-19 00:00:00
abstract：:The therapeutic effects of dextrorphan and ketamine, two non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, on neuropathic pain-related behaviors were examined in rats with peripheral mononeuropathy induced by loose ligation of the common sciatic nerve (chronic constrictive injury, CCI). Four daily intr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91368-3
更新日期：1993-03-05 00:00:00
abstract：:The entire set of giant interneurons (GIs) in the nerve cord of the cockroach, Periplaneta americana, was ablated using either electrolytic or surgical techniques. All animals with these lesions were capable of turning and running away from standard wind puffs. However, all animals responded much less frequently to st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91202-4
更新日期：1988-04-05 00:00:00
abstract：:Three different methods were used to examine the importance of the dorsal noradrenergic bundle projections from the locus coeruleus (LC) in activation of the neocortex and hippocampus in freely moving rats. (1) After cerebral norepinephrine (NE) was depleted by systemic neonatal injections of 6-hydroxydopamine (6-OHDA...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90785-5
更新日期：1977-12-09 00:00:00
abstract：:The main goal of the present study was to analyse the effects of (+/-)-huprine X ((+/-)-HX) and galantamine (GAL), with potentiating action on nicotinic receptors, and huperzine A (HPA), devoid of nicotinic activity, on [3H]-acetylcholine ([3H]-ACh) release in striatal slices of rat brain. All compounds are non-covale...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.07.042
更新日期：2005-11-09 00:00:00
abstract：:Adult male guinea pigs were castrated and 24 h later injected with [3H]dihydrotestosterone. Their pituitary glands were then processed for autoradiographic and immunocytochemical analyses. Three percent of the parenchymal cells in the pars distalis were radiolabelled. These cells were primarily gonadotrophs; a small p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90456-7
更新日期：1986-01-08 00:00:00
abstract：:Distribution of somatostatin (SS) immunoreactivity was observed in the preoptic-anterior hypothalamus (PO-AH) of the female rat brain. Six specific rabbit antibodies A (SS-14), B (SS-28), C (SS-28 complete), D (SS 14 and SS-28 both), E (SS preprohormone) and F (GHRH) were used for immunostaining using Avidin-Biotin Co...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03164-4
更新日期：2001-05-11 00:00:00
abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces dopaminergic neuron death in substantia nigra and dopamine loss in striatum, similar to those observed in Parkinson disease. Given MPTP can also induce alterations in brain cytokines and in peripheral immune parameters, we hypothesize that MPTP can induce an ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.03.009
更新日期：2005-05-31 00:00:00
abstract：:The behavioural response following infusion of a novel, stable substance P (SP) analogue, DiMe-C7, into the ventral tegmental area (VTA) of rats was characterized and contrasted with the response to an equal dose of the parent compound SP. DiMe-C7 produced a longer-lasting behavioural stimulation than SP as evidenced ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90777-6
更新日期：1982-04-22 00:00:00
abstract：:To elucidate the anatomical distribution of the serotonergic neurotransmitter system, we identified serotonin transporter (5-HTT) in the hippocampus of rats and monkeys by immunohistochemistry. A widespread and heterogeneous distribution of 5-HTT-immunoreactive fine fibers was noted in the rat brain. However, in monke...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.03.013
更新日期：2004-06-04 00:00:00
abstract：:Threatening stimuli are thought to bias spatial attention toward the location from which the threat is presented. Although this effect is well-established in the visual domain, little is known regarding whether tactile attention is similarly affected by threatening pictures. We hypothesised that tactile attention migh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.11.072
更新日期：2009-02-09 00:00:00
abstract：:Intracellular staining with recording micropipettes filled with a Procion yellow solution was attempted on 11 lateral geniculate neurons of chloralose-anesthetized cats for the purpose of correlating electrophysiologically identified cell types with morphologically identified cell types. Five neurons were successfully...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90058-6
更新日期：1978-01-06 00:00:00
abstract：:The enzymes catalyzing the breakdown of TRH are soluble and dependent upon active sulfhydryl groups. One of these enzymes is a pyroglutamyl aminopeptidase (EC 3.4.11.8) (apparent molecular weight 60,000 daltons) with a specificity restricted to pyroglutamyl peptide bonds. The second enzyme is a prolyl endopeptidase (a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90309-2
更新日期：1982-06-24 00:00:00
abstract：:In order to establish the basic connectivity of physiologically identified somatosensory regions of the thalamus and telencephalon in the pigeon, injections of wheatgerm agglutinin-horseradish peroxidase were made under electrophysiological control and the projections were charted following conventional neurohistochem...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/0006-8993(87)91127-9
更新日期：1987-06-02 00:00:00
abstract：:To evaluate a hypothesized role of the vagus in the circannual metabolic cycle of hibernators, measures of annual weight gain, weight loss and cycle period were taken for the ground squirrel, Citellus lateralis, maintained in constant environmental conditions before and after subdiaphragmatic vagotomy. The surgery did...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90996-0
更新日期：1986-01-29 00:00:00
abstract：:L-3, 4-Dihydroxyphenylalanine (L-dopa) has been widely used for the treatment of Parkinson's disease (PD), but its pharmacokinetics in the striatum have hardly been investigated, especially in primates. In this study, we examined the concentration of L-dopa in plasma and in the extracellular fluid (ECF) of the striatu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.08.065
更新日期：2003-12-12 00:00:00
abstract：:Close to 20% of the patients infected with the AIDS virus develops neurological deficit; eventhough HIV does not invade neurons. Consistently with the neurological deficit, HIV(+) subjects show abnormalities in brainstem auditory and visual evoked potentials (BSAEP and VEP) and in sleep patterns. The HIV-derived glyco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01572-3
更新日期：1999-07-31 00:00:00
