Abstract：
:Acute and repeated exposure to cocaine induces long-lasting alterations in neural networks that underlie compulsive drug seeking and taking. Cocaine exposure triggers complex adaptations in the brain that are mediated by dynamic patterns of gene expression that are translated into enduring changes. Recently, epigenetic modifications have been unveiled as critical mechanisms underlying addiction that contribute to drug-induced plasticity by regulating gene expression. These alterations are also now linked to the heritability of cocaine-induced phenotypes. This review focuses on how changes in the epigenome, such as altered DNA methylation, histone modifications, and microRNAs, regulate transcription of specific genes that contribute to cocaine addiction.
journal_name
Brain Resjournal_title
Brain researchauthors
Sadri-Vakili Gdoi
10.1016/j.brainres.2014.09.069subject
Has Abstractpub_date
2015-12-02 00:00:00pages
50-9issue
Pt Aeissn
0006-8993issn
1872-6240pii
S0006-8993(14)01342-0journal_volume
1628pub_type
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