Abstract：
:Abnormal development of the neocortex is often associated with cognitive deficits and epilepsy. Rodent models are widely used to study normal and abnormal cortical development and have revealed the roles of many important genetic and environmental factors. Interestingly, several inbred mouse strains commonly used in behavioral, anatomical, and/or physiological studies display neocortical malformations including C57BL/6J mice, which are among the most widely utilized mice. In the present report we describe the prevalence and cytoarchitecture of molecular-layer heterotopia in C57BL/6J mice and related strains obtained from three commercial vendors as well as mice bred in academic vivaria from founders obtained commercially. In particular, we found that the prevalence of molecular-layer heterotopia vaired according to the sex as well as the vendor-of-origin of the mouse. These data are relevant to the use of this strain as a mouse-model in the study of brain-behavior relationships.
journal_name
Brain Resjournal_title
Brain researchauthors
Lipoff DM,Bhambri A,Fokas GJ,Sharma S,Gabel LA,Brumberg JC,Richfield EK,Ramos RLdoi
10.1016/j.brainres.2011.03.026subject
Has Abstractpub_date
2011-05-19 00:00:00pages
36-43eissn
0006-8993issn
1872-6240pii
S0006-8993(11)00523-3journal_volume
1391pub_type
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