Abstract：
:The effects of selective dopamine (DA) depleting lesions with 6-hydroxydopamine microinjection into the SN, CPu, and NAS, as well as radiofrequency lesions of the CPu on the performance characteristics of rats trained on a single-valued 20-s peak-interval (PI) timing procedure or a double-valued 10-s and 60-s PI procedure were evaluated. A double dissociation in the performance of duration discriminations was found. Rats with CPu lesions were unable to exhibit temporal control of their behavior suggesting complete insensitivity to signal duration but were able to show discrimination of the relative reward value of a signal by differentially modifying their response rates appropriately. In contrast, rats with NAS lesions were able to exhibit temporal control of their behavior by differentially modifying their response rates as a function of signal duration(s), suggesting no impairment of sensitivity to signal duration, but were unable to show discrimination of the relative reward value of a signal.
journal_name
Brain Resjournal_title
Brain researchauthors
Meck WHdoi
10.1016/j.brainres.2006.06.031subject
Has Abstractpub_date
2006-09-13 00:00:00pages
93-107issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(06)01720-3journal_volume
1109pub_type
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