Abstract：
:Intravenous administration of the cholecystokinin (CCK) antagonist lorglumide (LORG) reversed chronic haloperidol (CHAL)-induced depolarization inactivation (DI) of dopamine (DA) cells in both the A9 and A10 areas. Moreover, microinjection of LORG, but not naloxone, directly into the medial nucleus accumbens (mNAc) dose-dependently reversed CHAL-induced effect. LORG injected into other brain regions was without effect. These results suggest that CCK receptors in the mNAc form an important link for maintaining CHAL-induced DI of DA cells and that CCK is involved in the therapeutic action of antipsychotic drugs.
journal_name
Brain Resjournal_title
Brain researchauthors
Jiang LH,Kasser RJ,Wang RYdoi
10.1016/0006-8993(88)90330-7subject
Has Abstractpub_date
1988-11-08 00:00:00pages
165-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(88)90330-7journal_volume
473pub_type
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