Abstract：
:It was previously proposed that norepinephrine (NE)-containing nerve terminals in visual cortex are important for the maintenance of cortical plasticity. Observations at that time indicated that local microperfusion of exogenous NE for 1 week directly into kitten visual cortex, with no alteration of the visual environment, resulted in an unexpected bias in ocular dominance toward the contralateral eye. The proportion of binocular cells, however, remained close to normal. In the present study, we examined this contralateral bias in visual cortical neurons addressing the following two issues: the time needed for change in ocular dominance to occur, and its dependence on visually evoked activity. We found no bias in ocular dominance toward the contralateral eye when the continuous local perfusion of 48 microM NE lasted for 3 days. Such change became obvious after 1 week. However, if the animal was placed in the dark during the period of NE perfusion, no change whatsoever in ocular dominance was observed. These results suggest that NE itself does not affect ocular dominance circuitry directly, since both high levels of NE and an extended period of visually evoked activity are necessary for the observed change in ocular dominance to occur. We conclude that the present results are consistent with the previously proposed role for NE in the modulation of visual cortical plasticity.
journal_name
Brain Resjournal_title
Brain researchauthors
Kuppermann BD,Kasamatsu Tdoi
10.1016/0006-8993(84)91288-5subject
Has Abstractpub_date
1984-06-04 00:00:00pages
91-9issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(84)91288-5journal_volume
302pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Converging evidence suggests that compromised motor abilities in hemiparetic cerebral palsy are not solely due to impairments in motor execution, but are also related to deficits in action planning. The present study had two aims. First, we compared grip planning in a sequential task between participants with left-sid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.12.074
更新日期：2009-03-19 00:00:00
abstract：:Hypothalamic nuclei close to the third ventricle (VIII) represent key structures in avian osmoregulation concerned with the control of salt gland activity and release of the antidiuretic hormone [Arg8]vasotocin (AVT). Nitric oxide (NO) acting as a paracrine transmitter in the hypothalamus has been shown to contribute ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01205-6
更新日期：1999-04-17 00:00:00
abstract：:A double-staining immunocytochemical study was done in ovariectomized (OVX) female rats that were either treated with 17beta-estradiol (E(2)) (OVX+E(2)) to produce an approximate circulating level of 30 pg/ml plasma, or not-treated with E(2) (OVX), to investigate the distribution of subfornical organ (SFO) neurons tha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01672-8
更新日期：1999-08-07 00:00:00
abstract：:Parkinson's disease is characterized by a loss of dopaminergic neurons in the substantia nigra and, in the most severe cases, by degeneration of mesopontine cholinergic neurons. In a monkey model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine we report that, despite a severe loss of dop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90088-5
更新日期：1993-10-08 00:00:00
abstract：:The present studies examined the hypothesis that the N-methyl-D-aspartate (NMDA) receptor-nitric oxide (NO) pathway might be involved in the acute and chronic actions of delta 9-tetrahydrocannabinol (THC). The ability of dizocilpine (MK-801), a competitive NMDA receptor antagonist and NG-monomethyl-L-arginine (L-NMMA)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91715-9
更新日期：1994-12-19 00:00:00
abstract：:We report the characterization of a new class of glutamate uptake inhibitors isolated from Phoneutria nigriventer venom. Glutamate transport activity was assayed in rat cerebrocortical synaptosomes by using [(3)H]-L-glutamate. PhTx4 inhibited glutamate uptake in a dose dependent manner. The IC(50) value obtained was 2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01472-9
更新日期：1999-06-12 00:00:00
abstract：:The distribution of calcitonin gene-related peptide (CGRP)-immunoreactive (IR) fibers and cell bodies was studied in the spinal cord and the medulla oblongata of the grey monkey (Macaca fascicularis) using peroxidase-antiperoxidase (PAP) immunohistochemistry. At all levels of the spinal cord many CGRP-IR motoneurons a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90787-v
更新日期：1991-09-06 00:00:00
abstract：:Stellate ganglion block (SGB) is a blockade of sympathetic ganglia innervating the head and neck, and is known to function through vasodilation of the target region. However, the effectiveness of SGB in relieving cerebral vasospasm (CVS) through dilation of intracerebral vessels has not been evaluated. The aim of the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.08.012
更新日期：2014-10-17 00:00:00
abstract：:Dopamine neurons are overstimulated by drugs of abuse and suffer molecular alterations that lead to addiction behavior. Nurr1 is a transcription factor crucial for dopamine neurons survival and dopamine production, activating the transcription of key genes like tyrosine hydroxylase (TH). Interestingly, nuclear factor-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.09.031
更新日期：2016-12-01 00:00:00
abstract：:The identification of biologically important and chemically well-defined substances that can promote axon and dendrite formation would improve present understanding of the development of the nervous system. Physiological concentrations of insulin and insulin-like growth factor-II (IGF-II) reversibly enhanced neurite o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90246-4
更新日期：1984-06-08 00:00:00
abstract：:Neurotensin is a putative peptide neurotransmitter in the mammalian brain. The light microscopic localization of the neurotensin receptor has been carried out by the autoradiographic localization of [3H]neurotensin binding sites in slide-mounted tissue sections. Large variations in receptor distribution were found, ev...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90532-1
更新日期：1981-02-16 00:00:00
abstract：:Thyrotropin-releasing hormone (TRH) prevents the development of drug- or stress-induced hyperglycemia in mice through action at central sites. To study the role of the pituitary in mediating this action, we have evaluated the effect of TRH analogs lacking hypophysiotropic activity, acid-TRH and DN 1417, in blocking gl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90135-7
更新日期：1988-07-05 00:00:00
abstract：:Using a double-label immunofluorescence method, we analyzed the time course of the appearance of Fos and Jun in the nuclei of supraoptic nucleus (SON) neurons following intraperitoneal injection of hypertonic saline. Fos and Jun immunostaining appeared within 30 min, peaked at 90-120 min, and disappeared 4-5 h later. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01216-4
更新日期：1997-01-23 00:00:00
abstract：:Quantitative morphological techniques have revealed several new aspects of the action of the Staggerer mutant gene. Staggerer is an autosomal recessive gene which causes ataxia and severe malformation of the cerebellar cortex in mice. The Purkinje cells of the cerebellar cortex are small, abnormal in morphology and re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90490-x
更新日期：1981-06-29 00:00:00
abstract：:Cytochrome aa3 (cyt aa3) is the main catalyst of cellular oxygen consumption. The properties of cyt aa3 will define the tissue oxygen requirements and provide an insight into energy supply and demand. Currently dual-wavelength (605-590 or 605-620 nm) reflectance spectrophotometry is used to monitor cyt aa3 redox state...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91236-3
更新日期：1985-12-23 00:00:00
abstract：:The content of the mRNAs that code for prepro-corticotropin releasing hormone (ppCRH), prepro-neurotensin/neuromedin N (ppNT/NMN) and prepro-enkephalin (ppENK) was measured using in situ hybridization histochemistry in the various subdivisions of the hypothalamic paraventricular nucleus (PVH) 4 h after a bout of ether...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90080-f
更新日期：1991-03-29 00:00:00
abstract：:We investigated the brain-stem pathway(s) by which electrical stimulation of the central cut end of the lingual nerve (LN) evokes parasympathetic reflex vasodilatation in the palate contralateral to the stimulated side. This occurs in artificially ventilated, cervically vagosympathectomized cats deeply anesthetized wi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.06.010
更新日期：2004-09-10 00:00:00
abstract：:Most functional neuroimaging techniques rely on activation-flow coupling (AFC) to detect changes in regional brain function, but AFC responses may also be altered during pathophysiological conditions such as ischemia. To define the relationship between progressive ischemia and the AFC response, graded levels of cerebr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.04.024
更新日期：2005-06-14 00:00:00
abstract：:We studied whether, similarly to the auditory modality, short-period temporal integration processes occur in vision. Event-related potentials (ERP) were recorded for occasional stimulus omissions from sequences of patterned visual stimuli. A posterior negative component emerged only when the constant stimulus onset as...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.034
更新日期：2006-08-09 00:00:00
abstract：:Using in vivo microdialysis, we examined the ability of choline (Ch) chloride (120 mg/kg i.p.) to amplify basal and stimulated acetylcholine (ACh) release from rat striatum in the presence of high (10(-5) M) and low (5 x 10(-8) M) neostigmine concentration. High concentrations might suppress ACh release, and thus Ch d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91330-u
更新日期：1993-12-03 00:00:00
abstract：:The present study utilized the [14C]2-deoxyglucose (2-DG) cell labeling procedure to characterize a functional pathway from the prefrontal cortex (Pfc) and mediodorsal thalamic nucleus (MD) to the hypothalamus. Rats were injected with 2-DG prior to a 45 min experimental paradigm consisting of alternating 30 s on-off p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90151-3
更新日期：1984-09-24 00:00:00
abstract：:Acute estradiol (E2) can potentiate the excitatory responses of hypothalamic ventromedial nucleus (VMN) neurons to neurotransmitters. To investigate the mechanism(s) underlying the potentiation, the whole-cell patch voltage clamp technique was used to study VMN neurons in hypothalamic slices prepared from female juven...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.07.104
更新日期：2006-10-20 00:00:00
abstract：:Bromodeoxyuridine (BrUdR) injected into Xenopus embryos at stages before, during or after the last period of DNA synthesis in Mauthner's neurons had no serious effect on differentiation of Mauthner's neurons. However, the BrUdR caused widespread cell degeneration in the central nervous system. The action of BrUdR on r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90819-3
更新日期：1978-07-21 00:00:00
abstract：:Chronic peripheral inflammation or peripheral neurectomy cause changes in GABA levels and GABA immunoreactivity in the spinal cord dorsal horn. The present study aimed to investigate if such changes are accompanied by alterations in GABA receptor binding. Neurectomy of the sciatic nerve caused an ipsilateral down-regu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00262-o
更新日期：1995-05-15 00:00:00
abstract：:Somatostatin neuronal perikarya and their processes, presumably dendrites, in the periventricular nucleus of the rat hypothalamus and terminals in the median eminence were observed by electron microscopic immunohistochemistry. Neuronal perikarya and processes contained immunoreactive dense granules (100-120 nm in diam...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91153-8
更新日期：1983-01-10 00:00:00
abstract：:Morphological and physiological effects of kainic acid (KA) lesions in rat ventral lateral geniculate nucleus (LGV) were studied 1.5 and 6 h after KA injection. Morphological changes were examined mainly by electron micrographs. At 1.5 h after KA injection dendrites were dilated and some vacuolations occurred in both ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90033-4
更新日期：1989-03-27 00:00:00
abstract：:Using an isolated neonatal rat spinal cord preparation, we have studied the ability of hydrogen peroxide to act as a source of oxygen for mammalian central nervous system (CNS) maintained in vitro. We report here that hydrogen peroxide, in low concentrations (0.001-0.004%), can effectively provide the only source, or ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90280-9
更新日期：1983-11-14 00:00:00
abstract：:The response of the endoneurial vasculature in rat sciatic nerve following crush injury was investigated by morphometric analysis of serial nerve transverse sections at the site of injury and in distal segments at 1, 2, 3, 6, and 9 weeks after injury. Quantitative analysis included determination of the number of vesse...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90018-i
更新日期：1993-09-24 00:00:00
abstract：:The modulation of serotonin (5-HT) release by opioid receptors in the hippocampus of the awake, unrestrained rat was evaluated by use of in vivo microdialysis. The hippocampus was perfused with Ringer's solution (2 microliters/min), and extracellular levels of 5-HT and its major metabolite, 5-hydroxyindoleacetic acid ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90456-w
更新日期：1993-06-04 00:00:00
abstract：:Threatening stimuli are thought to bias spatial attention toward the location from which the threat is presented. Although this effect is well-established in the visual domain, little is known regarding whether tactile attention is similarly affected by threatening pictures. We hypothesised that tactile attention migh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.11.072
更新日期：2009-02-09 00:00:00
