Hydrogen peroxide as a source of molecular oxygen for in vitro mammalian CNS preparations.

Abstract:

:Using an isolated neonatal rat spinal cord preparation, we have studied the ability of hydrogen peroxide to act as a source of oxygen for mammalian central nervous system (CNS) maintained in vitro. We report here that hydrogen peroxide, in low concentrations (0.001-0.004%), can effectively provide the only source, or act as a supplementary source of oxygen. This is brought about via the intracellular enzyme catalase which catalyzes the conversion of H2O2 into molecular oxygen and water.

journal_name

Brain Res

journal_title

Brain research

authors

Walton K,Fulton B

doi

10.1016/0006-8993(83)90280-9

subject

Has Abstract

pub_date

1983-11-14 00:00:00

pages

387-93

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(83)90280-9

journal_volume

278

pub_type

杂志文章
  • Low but not high rate noxious radiant skin heating evokes a capsaicin-sensitive increase in spinal cord dorsal horn release of substance P.

    abstract::Some kinds of nociception appear to be partially mediated by the release of substance P (SP) in the spinal cord dorsal horn from terminals of primary afferent nociceptors. Only some nociceptors contain and release SP however. Specifically, SP appears to be released by unmyelinated (C) nociceptive afferents when activa...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(96)01466-7

    authors: Zachariou V,Goldstein BD,Yeomans DC

    更新日期:1997-03-28 00:00:00

  • Cholinergic and noradrenergic toxicity of intraventricular aluminum chloride in the rat hippocampus.

    abstract::The effects of the intraventricular administration of aluminum chloride (AlCl3) on high affinity choline transport (HAChT) and norepinephrine concentration were examined in the hippocampus of the rat. Controlling for osmolarity and pH, the intraventricular administration of AlCl3 resulted in a dose-related reduction i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)91121-9

    authors: Zubenko GS,Hanin I

    更新日期:1989-10-02 00:00:00

  • Influences of pituitary-adrenal hormones on kindling.

    abstract::The kindling process represents a progressively augmenting electrical and behavioral response to brain stimulation, that has been proposed as a model for the development of epileptogenesis. The first experiment examined the effects of hypophysectomy on the kindling process. The effects of hypophysectomy were found to ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(79)91032-1

    authors: Rose RP,Morell F,Hoeppner TJ

    更新日期:1979-06-22 00:00:00

  • Suppression of acute seizures by theta burst electrical stimulation of the hippocampal commissure using a closed-loop system.

    abstract::This study investigated the effects of electrical stimulation with theta burst stimulation (eTBS) on seizure suppression. Optimal parameters of eTBS were determined through open-loop stimulation experiments and then implemented in a close-loop seizure control system. For the experiments, 4-aminopyridine (4-AP) was inj...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2014.10.025

    authors: Siah BH,Chiang CC,Ju MS,Lin CC

    更新日期:2014-12-17 00:00:00

  • Expression and distribution of mTOR, p70S6K, 4E-BP1, and their phosphorylated counterparts in rat dorsal root ganglion and spinal cord dorsal horn.

    abstract::Mammalian target of rapamycin (mTOR) controls protein translation and has an important role in the mechanism of pain hypersensitivity under persistent pain conditions. However, its expression and localization in pain-related regions of the nervous system is not completely understood. Here, we examined the expression a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.04.010

    authors: Xu JT,Zhao X,Yaster M,Tao YX

    更新日期:2010-06-08 00:00:00

  • Induction of NMDA receptor-independent long-term potentiation (LTP) in visual cortex of adult rats.

    abstract::The aim of this study was to examine: (1) whether long-term potentiation (LTP) can be induced in slices from adult rat visual cortex under conditions where inhibition is not antagonized, and (2) the role of N-methyl-D-aspartate (NMDA) receptors in its induction. The field potential elicited in layer III in response to...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90891-c

    authors: Aroniadou VA,Teyler TJ

    更新日期:1992-07-03 00:00:00

  • Preconditioning of primary rat neuronal cultures against ischemic injury: characterization of the "time window of protection'.

    abstract::Primary rat neuronal cultures can be preconditioned against ischemic damage by several mechanisms. In the present study we established a new model system in order to characterize the "time window of protection' obtained by preconditioning of neurons with adenosine. Ischemia was simulated by exposure of the cultures to...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(96)00939-0

    authors: Reshef A,Sperling O,Zoref-Shani E

    更新日期:1996-11-25 00:00:00

  • Short latency excitation of upper cervical respiratory neurons by vagal stimulation in the rat.

    abstract::Extracellular recordings were made from 29 respiration-phased neurons in the upper cervical spinal cord (C1-C3) in nine anesthetized rats while ipsilateral and contralateral vagi were stimulated via platinum hook electrodes. Neuronal responses to vagal stimulation were recorded using peristimulus histograms. An accumu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)91143-3

    authors: Dawkins MA,Foreman RD,Farber JP

    更新日期:1992-10-30 00:00:00

  • Retinotopically inappropriate synapses of subnormal density formed by surgically misdirected optic fibers in goldfish tectum.

    abstract::Selected optic fibers were surgically deflected from one tectum onto the opposite host tectum which was denervated by eye enucleation. At 6-8 months, deflected fibers were labeled with horseradish peroxidase and the retinotopically inappropriate part of tectum was examined using electron microscopy. Numerous (labeled)...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(88)90058-2

    authors: Hayes WP,Meyer RL

    更新日期:1988-02-01 00:00:00

  • S(+)methylenedioxy-N-n-propylnoraporphine: an orally active inhibitor of dopamine selective for rat limbic system.

    abstract::The 10-11-methylenedioxy (MDO) derivative of S(+)N-n-propylnorapomorphine (NPA) was prepared and tested as a possible active prodrug to S(+)NPA, which we have recently found to exert in vivo activity suggestive of selective antagonism of dopamine receptors in the limbic forebrain but not the extrapyramidal basal gangl...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)90083-7

    authors: Campbell A,Baldessarini RJ,Kula NS,Ram VJ,Neumeyer JL

    更新日期:1987-02-17 00:00:00

  • Quantitation and morphological characterization of rapid axon and dendritic growth from single cerebral hemispheric neurons in hydrated collagen lattice culture.

    abstract::Quantitative and qualitative data are reported for single cerebral hemispheric neurons in a 3-dimensional hydrated collagen lattice (HCL) culture system. Individual neurons not in contact with other cells or cell processes, including synapses, rapidly displayed two morphologically distinct classes of processes that co...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(86)90147-1

    authors: Coates PW

    更新日期:1986-02-01 00:00:00

  • Microinjection of muscimol into caudal periaqueductal gray lowers body temperature and attenuates increases in temperature and activity evoked from the dorsomedial hypothalamus.

    abstract::Microinjection of the neuronal inhibitor muscimol into the midbrain lateral/dorsolateral periaqueductal gray (l/dlPAG) suppresses increases in heart rate (HR) and mean arterial pressure (MAP) evoked by microinjection of the GABA(A) receptor antagonist bicuculline methiodide (BMI) into the dorsomedial hypothalamus (DMH...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.03.080

    authors: de Menezes RC,Zaretsky DV,Fontes MA,DiMicco JA

    更新日期:2006-05-30 00:00:00

  • Selective opioid agonist and antagonist competition for [3H]-naloxone binding in amphibian spinal cord.

    abstract::Opioids elicit antinociception in mammals through three distinct types of receptors designated as mu, kappa and delta. However, it is not clear what type of opioid receptor mediates antinociception in non-mammalian vertebrates. Radioligand binding techniques were employed to characterize the site(s) of opioid action i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02967-x

    authors: Newman LC,Wallace DR,Stevens CW

    更新日期:2000-11-24 00:00:00

  • Discordant changes between immunoreactive ACTH and beta-endorphin in rat brain and pituitary during early development.

    abstract:UNLABELLED:Discordant changes in brain concentrations of immunoreactive (IR-) adrenocorticotropic hormone (ACTH) or beta-endorphin, peptides derived from pro-opiomelanocortin (POMC), have been reported during the latter part of development and with subsequent aging. These changes were believed to be due to age-related ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)90847-4

    authors: Kapcala LP

    更新日期:1986-02-05 00:00:00

  • Plasma epinephrine modulates the cerebrovasodilation evoked by electrical stimulation of dorsal medulla.

    abstract::We examined whether plasma epinephrine contributes to the increase in regional cerebral blood flow (rCBF) evoked by electrical stimulation of the dorsal medullary reticular formation (DMRF). Rats were anesthetized (alpha-chloralose, 30 mg/kg, s.c.), paralyzed and artificially ventilated. The DMRF was electrically stim...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91203-s

    authors: Lacombe PM,Iadecola C,Underwood MD,Sved AF,Reis DJ

    更新日期:1990-01-01 00:00:00

  • Developmental changes in cerebrospinal fluid pressure and resistance to absorption in rats.

    abstract::Cerebrospinal fluid (c.s.f.) pressure and resistance to absorption have been studied in exteriorized fetuses (18 to 21 days gestation) from pregnant rats anaesthetised with pentobarbitone and in similarly anaesthetised postnatal rats at 1, 5, 10 and 30 days after birth and in adults. The resting c.s.f. pressure was lo...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(87)90172-6

    authors: Jones HC,Deane R,Bucknall RM

    更新日期:1987-05-01 00:00:00

  • Spatial and temporal response properties of secondary neurons that receive convergent input in vestibular nuclei of alert cats.

    abstract::Responses to rotation in many vertical and horizontal planes were studied in electrically identified secondary vestibular neurons of alert cats. This report concerns secondary neurons that gave responses which could not be explained as due to a summation of semicircular canal inputs. These cells responded to sinusoida...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)91318-0

    authors: Baker J,Goldberg J,Hermann G,Peterson B

    更新日期:1984-02-27 00:00:00

  • Differences in AMPA and GABAA/B receptor subunit expression between the chronically reorganized cortex and brainstem of adult squirrel monkeys.

    abstract::The primate somatosensory neuraxis provides a highly translational model system with which to investigate adult neural plasticity. Here, we report immunohistochemical staining data for AMPA and GABAA/B receptor subunits of area 3b cortex and cuneate nucleus of adult squirrel monkeys one to five years after median and ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.03.010

    authors: Mowery TM,Sarin RM,Kostylev PV,Garraghty PE

    更新日期:2015-06-22 00:00:00

  • Local field potential correlates of auditory working memory in primate dorsal temporal pole.

    abstract::Dorsal temporal pole (dTP) is a cortical region at the rostral end of the superior temporal gyrus that forms part of the ventral auditory object processing pathway. Anatomical connections with frontal and medial temporal areas, as well as a recent single-unit recording study, suggest this area may be an important part...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.12.025

    authors: Bigelow J,Ng CW,Poremba A

    更新日期:2016-06-01 00:00:00

  • Regional differences in the effects of forced swimming on extracellular levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid.

    abstract::The effects of forced swimming for 30 min on extracellular 5-hydroxytryptamine (5-HT) levels were examined in five brain regions in rats using in vivo microdialysis. A single dialysis probe was implanted under surgical anesthesia into either the striatum, ventral hippocampus, frontal cortex, amygdala, or lateral septu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00349-u

    authors: Kirby LG,Allen AR,Lucki I

    更新日期:1995-06-05 00:00:00

  • Method of administration determines the effect of naloxone on pain.

    abstract::The opiate antagonist, naloxone, produces dose-dependent biphasic changes in clinical pain. The mechanism of the analgesia produced by low dose naloxone is unknown. To study the analgesic effect of naloxone, we have used a programmable infusion pump, which eliminates placebo-induced endorphin-mediated analgesia, to ad...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)91653-7

    authors: Levine JD,Gordon NC

    更新日期:1986-02-19 00:00:00

  • A correlation between multiple unit activity in the hypothalamus and electrocardiographic changes during a subarachnoid hemorrhage.

    abstract::A sudden onset and short latency of cardiovascular responses that may follow a subarachnoid hemorrhage (SAH) in the vicinity of the circle of Willis implicate neural mechanisms. To investigate this, multi unit activity (MUA) was recorded from the posterolateral hypothalamus and electrocardiogram was recorded from lead...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)90324-0

    authors: Lacy PS,Earle AM

    更新日期:1986-05-14 00:00:00

  • Oxygen-induced apoptosis in PC12 cells with special reference to the role of Bcl-2.

    abstract::We previously reported that PC12h cells are killed by a high oxygen atmosphere. In this study, we further characterized this oxygen-induced cell death and found apoptotic features, as follows. Firstly, chromatin condensation was observed in cells cultured in a 50% O2 atmosphere. Secondly, cycloheximide and cordycepin,...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(96)00542-2

    authors: Kubo T,Enokido Y,Yamada M,Oka T,Uchiyama Y,Hatanaka H

    更新日期:1996-09-16 00:00:00

  • The effect of raphe lesion on sleep in the rat.

    abstract::The midbrain raphe nuclei (nucleus raphe dorsalis and nucleus raphe medialis) were destroyed by electrocoaggulation in rats. On the first few days following the lesion, a marked hyperactivity was observed in lesioned animals as well as in shame-operated controls. Between the 5th and 36th days after the lesion, sleep p...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)91218-4

    authors: Juvancz P

    更新日期:1980-08-04 00:00:00

  • Involvement of TNF-alpha in glutamate-induced apoptosis in a differentiated neuronal cell line.

    abstract::We examined the involvement of tumor necrosis factor (TNF)-alpha on glutamate-induced cytotoxicity in a differentiated neuronal cell line. In this study, we used nerve growth factor (NGF)-differentiated PC12h cells. Glutamate cytotoxicity was assessed using the MTS and TUNEL assays. To detect TNF-alpha levels in cultu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.09.006

    authors: Kogo J,Takeba Y,Kumai T,Kitaoka Y,Matsumoto N,Ueno S,Kobayashi S

    更新日期:2006-11-29 00:00:00

  • Localization of brain activity during auditory verbal short-term memory derived from magnetic recordings.

    abstract::We have studied magnetic and electrical fields of the brain in normal subjects during the performance of an auditory verbal short-term memory task. On each trial 3 digits, selected from the numbers 'one' through 'nine', were presented for memorization followed by a probe number which could or could not be a member of ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90767-p

    authors: Starr A,Kristeva R,Cheyne D,Lindinger G,Deecke L

    更新日期:1991-09-06 00:00:00

  • Stable long-term recordings from cat peripheral nerves.

    abstract::A procedure has been developed for the stable long-term recording of nerve signals in unanesthetized mammals, which should have wide application in basic research on the nervous system and also in clinical areas such as the derivation of control signals for powered prostheses. Methods are fully described for construct...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(77)90233-5

    authors: Stein RB,Nichols TR,Jhamandas J,Davis L,Charles D

    更新日期:1977-06-03 00:00:00

  • Effects of postpuberal gonadectomy on the neurosensorial epithelium of the vomeronasal organ in the rat.

    abstract::In the present report the effects of postpuberal gonadectomy on vomeronasal organ (VO) morphology were studied. Postpuberal gonadectomy induced in both male and female rats a decrement in the height of the epithelium and in the nuclear size of the bipolar neurons. These results show that the maintenance of neurosensor...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(84)90315-8

    authors: Segovia S,Paniagua R,Nistal M,Guillamon A

    更新日期:1984-06-01 00:00:00

  • Effect of thyrotropin releasing hormone on U-50,488H-induced pharmacological responses in mice.

    abstract::The effect of thyrotropin releasing hormone (TRH) administered either subcutaneously (s.c.) or intracerebroventricularly (i.c.v.) on the analgesic and hypothermic actions of U-50,488H, a highly selective kappa-opiate agonist, was determined in male Swiss Webster mice. Intraperitoneal administration of U-50,488H (8-32 ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90144-c

    authors: Bhargava HN,Thorat SN

    更新日期:1993-10-15 00:00:00

  • Quantitative examination of the deep cerebellar nuclei in the staggerer mutant mouse.

    abstract::Quantitative morphological techniques have revealed several new aspects of the action of the Staggerer mutant gene. Staggerer is an autosomal recessive gene which causes ataxia and severe malformation of the cerebellar cortex in mice. The Purkinje cells of the cerebellar cortex are small, abnormal in morphology and re...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90490-x

    authors: Roffler-Tarlov S,Herrup K

    更新日期:1981-06-29 00:00:00