Abstract:
:Quantitative morphological techniques have revealed several new aspects of the action of the Staggerer mutant gene. Staggerer is an autosomal recessive gene which causes ataxia and severe malformation of the cerebellar cortex in mice. The Purkinje cells of the cerebellar cortex are small, abnormal in morphology and reduced in numbers. The close synaptic and developmental relationship of Purkinje cells with the cells of the deep cerebellar nuclei (dcn) lead us to look for effects of the Staggerer mutation on the dcn neurons. The volume of the deep nuclear region is shrunken in Staggerer and there is a reduction in the volume of the white matter. These findings account for the reduced wet weights and protein concentration found by Roffler-Tarlov and Sidman. In contrast to the cells of the cortex, where 75% of the medium-to-large neurons are missing, the number of cells present in Staggerer dcn is identical to wild-type. The dcn neurons are not completely spared, however. Measurements of cross-sectional cell area revealed a 30% shrinkage of neurons in Staggerer dcn. The most likely interpretation of previous work and the current findings is that the Staggerer gene acts early in development but exerts its effects directly only on those derivatives of the ventricular zone in the roof of the fourth ventricle which are destined to become Purkinje and Golgi cells.
journal_name
Brain Resjournal_title
Brain researchauthors
Roffler-Tarlov S,Herrup Kdoi
10.1016/0006-8993(81)90490-xsubject
Has Abstractpub_date
1981-06-29 00:00:00pages
49-59issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(81)90490-Xjournal_volume
215pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Transient foci of epileptiform alteration in neuronal population activity were induced by microinjection of strychnine sulfate into different layers of cat striate cortex. Potentials evoked by visual field-specific photic stimulation were recorded from microelectrodes at the injection site and in adjacent laminae. Epi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90938-2
更新日期:1985-08-12 00:00:00
abstract::Experiments were performed in the male Wistar rat to investigate the projections from cardiovascular responsive sites in the ventrolateral medulla (VLM) to the subfornical organ (SFO). Unilateral iontophoretic injections of Phaseolus vulgaris leucoagglutinin (PHA-L) were made into either caudal VLM (CVLM) sites at whi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.12.029
更新日期:2004-04-02 00:00:00
abstract::In the present study, the effects of bilateral injections of N-methyl-d-aspartate (NMDA) receptor agonist and/or antagonist into the central amygdala (CeA) on the acquisition and expression of morphine-induced conditioned place preference (CPP) were investigated in male Wistar rats. Animals that received 3 daily subcu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.11.049
更新日期:2007-02-16 00:00:00
abstract::The Fragile X mental retardation syndrome is the largest source of inherited mental retardation. The syndrome usually results from the transcriptional silencing of the fragile X mental retardation gene (FMR1). To date the most prominent reported neuronal abnormalities for the fragile X mental retardation syndrome incl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02363-1
更新日期:2003-05-02 00:00:00
abstract::Fetal mouse retinal ganglion cell axons have been shown to ramify within co-cultured basement membrane secreting tumor explants and upon isolated basement membranes. Here we report that laminin, a glycoprotein found in basement membranes and adhesion sites of a variety of cell types, acted as a substrate for retinal e...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90184-6
更新日期:1984-01-01 00:00:00
abstract::Our previous study [32] indicated that blockade of kappa-opioid receptors with nor-binaltorphimine (nor-BNI) in the medial preoptic area (MPOA) produced two different LH responses during midpregnancy in the rat: an increase in basal pulsatile LH secretion, followed in many cases by a larger and/or sustained increase i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00874-p
更新日期:1995-11-06 00:00:00
abstract::Sex differences in estrogen-induced progestin receptors have been described in specific regions of the rat brain. To determine if alpha 1-neurotransmission plays a role in the expression of the sex differences in progestin receptor induction, the effects of the alpha 1-antagonist, prazosin, on progestin binding in mic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90631-K
更新日期:1990-04-02 00:00:00
abstract::Event-related brain potentials were used to study the neural mechanisms underlying goal-directed object use distinguishing between processes supporting immediate and final action goals during action planning and execution. Subjects performed a grasping and transportation task in which actions were cued either with the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.02.085
更新日期:2007-05-07 00:00:00
abstract::Adult human bone marrow stromal cells (hMSCs) grown in suspension culture gave rise to spheres of neural progenitor (NP) cells, capable of expressing both dopaminergic (DA) and GABAergic (GABA) traits. After transplantation into the Parkinsonian rat, human NPs and neurons were present at 2 weeks. Although no DA neuron...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.05.109
更新日期:2006-08-23 00:00:00
abstract::Cerebral amyloid angiopathy (CAA) might disturb the sensitive mechanism of cerebral pressure autoregulation. This study examines whether dynamic cerebral autoregulation (CA) is impaired in the posterior or anterior circulation of CAA patients. Fifteen patients with known CAA on magnetic resonance imaging (MRI) and 14 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.04.014
更新日期:2019-08-15 00:00:00
abstract::It has been reported that training affects motor responses evoked electrically from the dorsomedial frontal cortex (DMFC). Once a monkey had been trained to generate visually-guided saccadic eye movements of a particular size and direction, electrical stimulation of the DMFC elicited saccades of only that size and dir...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02663-9
更新日期:2000-09-15 00:00:00
abstract::The subfornical organ, along with other regions of the lamina terminalis, may contain osmoreceptors and is likely to be a site of action of blood-borne angiotensin II. The neural pathways by which these stimuli lead to vasopressin secretion, have been suggested to extend from the subfornical organ to hypothalamic site...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90708-4
更新日期:1991-08-30 00:00:00
abstract::The effects of a wide range of doses of systemically administered cysteamine were studied on locomotor behavior, passive avoidance memory, cortical and cerebrospinal fluid somatostatin-like immunoactivity and cortical levels of dopamine and norepinephrine. High doses of cysteamine (200 and 250 mg/kg s.c.) led to susta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90060-6
更新日期:1987-02-17 00:00:00
abstract::The behavioral and physiological effects of electrical stimulation of the nucleus locus coeruleus (LC) were studied in the awake rat. LC electrodes consistently supported high rates of self-stimulation (SS). LC stimulation also inhibited spontaneous cellular discharges in the hippocampus (HPC). Both the LC-induced inh...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90140-2
更新日期:1976-05-14 00:00:00
abstract::Microspectrofluorimetric measurements of excitatory amino acid-evoked rises in intracellular free calcium concentration ([Ca2+]i), electrophysiological measurements of currents through single NMDA receptor-operated ion channels and estimates of cellular viability following NMDA challenge were employed to examine the i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00771-h
更新日期:1995-11-06 00:00:00
abstract::Effects of taurine on endogenous aspartic acid (Asp), glutamic acid (Glu) and gamma-aminobutyric acid (GABA) release has been investigated using synaptosomes prepared from rat cerebral cortex. Although basal release of these amino acids was not affected, taurine inhibited KCl (30 mM)-evoked overflow of Asp, Glu and GA...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90318-h
更新日期:1993-11-12 00:00:00
abstract::In 16-week-old Sprague-Dawley rats lightly anesthetized with pentobarbital, 5-HT (3-96 micrograms/kg, i.v.; n = 6) produced distinct pseudaffective responses and a dose-dependent (slope = 17.2 +/- 6.8 s/log10 dose) inhibition of the tail-flick (TF) reflex (ED50 = 32.6 +/- 9.2 micrograms/kg). In the same rats, a 1:1 co...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90749-l
更新日期:1991-10-04 00:00:00
abstract::Ca2+-permeable AMPA receptors (AMPAR) which crucially modify maturational programs of the developing brain are involved in seizure-induced glutamate excitotoxicity and apoptosis. Regulatory effects on AMPAR subunit composition and RNA-editing in the developing brain and their significance as therapeutic targets are no...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.146760
更新日期:2020-05-15 00:00:00
abstract::The effects of oligemia (moderate ischemia) on the brain need to be explored because of the potential role of subtle microvascular changes in vascular cognitive impairment and dementia. Chronic bilateral common carotid artery occlusion (BCCAO) in adult rats has been used to study effects of oligemia (hypoperfusion) us...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.06.018
更新日期:2005-08-02 00:00:00
abstract::The effects of acute opiate receptor stimulation on regional cerebral oxygen consumption and blood flow were examined in 9 regions of the artificially respired, alpha-chloralose-anesthetized cat. Regional cerebral arterial and venous oxygen saturation were examined microspectrophotometrically and regional cerebral blo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91262-9
更新日期:1984-01-23 00:00:00
abstract::Amitriptyline, a representative tricyclic antidepressant, has been widely used for the treatment of neuropathic pain, such as post-herpetic and trigeminal neuralgia. In the present study, we investigated the effect of amitriptyline on glycinergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) in acute...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.03.030
更新日期:2012-05-21 00:00:00
abstract::The treatment of acute and chronic pain is still deficient. The modulation of glial cells may provide novel targets to treat pain. We hypothesize that astrocytes and microglia participate in the initiation and maintenance of both, acute surgical and chronic neuropathic pain. Rats underwent paw incision, L5 nerve expos...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.05.004
更新日期:2008-07-11 00:00:00
abstract::We investigated the effects of inverting facial contour (hair and chin) and features (eyes, nose and mouth) on processing for static and dynamic face perception using magnetoencephalography (MEG). We used apparent motion, in which the first stimulus (S1) was replaced by a second stimulus (S2) with no interstimulus int...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.01.091
更新日期:2011-04-06 00:00:00
abstract::Nutrients in the intestine inhibit food intake via an action on the vagal afferent pathway. The aim of the present study was to use immunochemical detection of Fos protein-like immunoreactivity (FLI) in the brainstem to trace the neuronal pathways activated by intestinal nutrients. Perfusion of the intestine of awake ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91272-6
更新日期:1994-11-14 00:00:00
abstract::The effects of repeated, once daily exposure to either restraint or tail pinch stress on extracellular levels of dopamine in nucleus accumbens and striatum were electrochemically monitored in conscious rats using high-speed chronoamperometry. Acutely, both tail pinch and restraint increased extracellular dopamine leve...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91639-v
更新日期:1992-07-24 00:00:00
abstract::In the neocortex, fast excitatory synaptic transmission can typically be blocked by using excitatory amino acid (EAA) receptor antagonists. In recordings from layer II/III neocortical pyramidal neurons, we observed an evoked excitatory postsynaptic potential (EPSP) or current (EPSC) in the presence of EAA receptor ant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03076-6
更新日期:2000-12-29 00:00:00
abstract::It is known that the execution of the motor response in a simple reaction time (RT) task can be delayed by transcranial magnetic stimulation (TMS). This paper is aimed at determining the site of action where the delay in RT occurs. A delay in RT was obtained only at those TMS sites over the motor cortex contralateral ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01062-1
更新日期:1997-01-02 00:00:00
abstract::Endogenous opioids play a role in the regulation of LH-RH neurosecretion throughout the estrous cycle and during the preovulatory LH surge on proestrus. Experimental evidence suggests that opioid influence may be altered with age, and it has been hypothesized that these alterations may contribute to the loss of regula...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91717-7
更新日期:1993-01-22 00:00:00
abstract::In previous studies we have tested the hypothesis that the termination of the period of sexual behavior in female guinea pigs results from the loss of progestin receptors from hypothalamic cell nuclei. We have shown that hormonal manipulations that delay heat termination also delay loss of hypothalamic nuclear progest...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90320-3
更新日期:1986-05-14 00:00:00
abstract::The present report summarizes the results obtained in previous experiments in which the responses to lateral tilt of both reticulocerebellar neurons located in the lateral reticular nucleus (NRL) and ascending spinoreticular tract axons, located in the lateral funiculi of the cervical segments C2-C3, had been recorded...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90112-2
更新日期:1975-09-23 00:00:00