Abstract:
:The behavioral and physiological effects of electrical stimulation of the nucleus locus coeruleus (LC) were studied in the awake rat. LC electrodes consistently supported high rates of self-stimulation (SS). LC stimulation also inhibited spontaneous cellular discharges in the hippocampus (HPC). Both the LC-induced inhibition of HPC units and the LC-evoked SS behavior were antagonized by alpha-methyltyrosine and 6-hydroxydopamine. In addition, chlorpromazine and diethyldithiocarbamate antagonized LC-induced inhibition of HPC units. D-Amphetamine facilitated SS behavior and reduced spontaneous HPC unit activity. The reinforcing properties of LC stimulation correlate closely with inhibition of cellular activity in the hippocampus; both actions appear to be mediated by norepinephrine.
journal_name
Brain Resjournal_title
Brain researchauthors
Segal M,Bloom FEdoi
10.1016/0006-8993(76)90140-2subject
Has Abstractpub_date
1976-05-14 00:00:00pages
499-511issue
3eissn
0006-8993issn
1872-6240pii
0006-8993(76)90140-2journal_volume
107pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Until now, there has been no effective therapy for chronic sensorineural hearing impairment. This study investigated the role of bone marrow cells (BMCs) in cochlear dysfunction. BALB/c mice (2 months of age), a non-presbycusis-prone mouse strain, were lethally irradiated and then transplanted with BMCs from SAMP1 mic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.08.074
更新日期:2006-11-20 00:00:00
abstract::Homer1a is implicated in depression in humans and depression-like behavior in mice. To further understand the role of Homer1a in stress-induced emotional changes, we applied very mild stress to Homer1a knockout (H1a KO) mice. The wild-type (WT) and H1a KO mice were restrained for 2h daily for 7 consecutive days at the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.02.008
更新日期:2015-04-24 00:00:00
abstract::Vanilloid (capsaicin) receptors were visualized by [3H]resiniferatoxin (RTX) autoradiography in the brain of newborn as well as adult (both control and colchicine-treated) rats. Specific labelling was seen in the brain stem only, in the nucleus of the solitary tract extending into the area postrema and the spinal sens...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01094-7
更新日期:1995-12-12 00:00:00
abstract::Rats were given unilateral 6-hydroxydopamine (6-OHDA) lesions and subsequently received transplants of fetal ventral mesencephalic tissue into the denervated striatum. Four weeks later transplanted animals were tested for graft-mediated reduction of amphetamine-induced rotational behavior. Subsequently, transplanted a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01921-6
更新日期:1999-10-16 00:00:00
abstract::We have shown that, when an amyloid-beta peptide (Abeta) overproducing transgenic mouse model (PSAPP) of Alzheimer's disease (AD) is treated with a depleting antibody against CD40L, it causes marked attenuation of Abeta pathology associated with decreased amyloidogenic processing of amyloid precursor protein (APP) and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.05.004
更新日期:2004-07-23 00:00:00
abstract::The axonal transport of radiolabeled slow phase proteins and fast phase glycoproteins was studied in rabbit hypoglossal nerve one week after axotomy. The nerves were ligated and cut to prevent axonal regeneration into the distal stump. In this situation of obstructed axonal outgrowth, the axonal transport of these com...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90953-2
更新日期:1982-10-28 00:00:00
abstract::Strong evidence obtained from in vivo and ex-vivo studies suggests the existence of interaction between dopaminergic and nitrergic systems. Some of the observations suggest a possible implication of nitric oxide (NO) in dopamine (DA) uptake mechanism. The present work investigated the interaction between both systems ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.12.054
更新日期:2008-03-10 00:00:00
abstract::Dopamine neurons are overstimulated by drugs of abuse and suffer molecular alterations that lead to addiction behavior. Nurr1 is a transcription factor crucial for dopamine neurons survival and dopamine production, activating the transcription of key genes like tyrosine hydroxylase (TH). Interestingly, nuclear factor-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.09.031
更新日期:2016-12-01 00:00:00
abstract::The effects of spinal cord hemisection on protein labeling in the medulla, pons, midbrain, and cortex in the Cebus monkey were studied by measuring the uptake of [3H]lysine into the trichloroacetic acid (TCA) precipitable and non-precipitable fractions of brain. Animals were sacrificed 3, 6 or 13 days after hemisectio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90458-9
更新日期:1977-02-25 00:00:00
abstract::The present study was designed to investigate the existence of two key enzymes involved in the metabolism of gamma-aminobutyric acid, glutamic acid decarboxylase (GAD) and glutamine synthetase (GS), in the area postrema (AP) of the cat. The results showed that punctuate structures of variable size corresponding to axo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90320-9
更新日期:1987-05-05 00:00:00
abstract::Chemical (C) kindling by means of repeated spaced injections into the amygdala (AM) of a subconvulsive dose of L-glutamate and L-aspartate combined in a molar ratio of 1:3. (Glu/Asp) produced progressive seizure development culminating in generalized convulsion strikingly similar to electrically kindled Stage 5 seizur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90481-1
更新日期:1987-11-03 00:00:00
abstract::A novel putative receptor for (3-8)angiotensin (AngIV) has recently been found in various tissues, including the brain. However, the localization of AngIV binding sites to specific types of brain cells has yet to be established. In this study tissue culture was used to determine the presence and characteristics of Ang...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00278-x
更新日期:1995-05-29 00:00:00
abstract::The hypothesis that early social isolation results in long-term alterations in dopamine receptor sensitivity was tested using older adult rhesus monkeys. Isolated and control monkeys were challenged with apomorphine (0.1 and 0.3 mg/kg), and the drug effects on spontaneous blink rate, stereotyped behavior, and self-inj...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91089-y
更新日期:1990-04-09 00:00:00
abstract::Soman is an organophosphorus (OP) compound which irreversibly inhibits acetylcholinesterase (AChE), the primary synaptic inactivator of acetylcholine. Resultant excessive cholinergic activity elicits generalized convulsions and brain lesions. Recent evidence suggests that other neurotransmitter/neuromodulator systems ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01315-7
更新日期:1997-02-07 00:00:00
abstract::An antagonist to amino acid evoked excitation, gamma-D-glutamylglycine (gamma-DGG) inhibits, dose-dependently, nociceptive C-fibre evoked field potentials and neuronal discharges in single nociceptive neurons in rat spinal cord. It is concluded that amino acids are possible transmitter substance(s) in nociceptive affe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90798-5
更新日期:1986-08-06 00:00:00
abstract::The effect of intrathecal (i.t.) galanin (GAL) on the prolonged increase of spinal reflex excitability produced by conditioning stimulation (CS) of unmyelinated muscle afferents was studied in decerebrate, spinalized, unanesthetized rats. A CS train (1 Hz, 20 s) applied to the unmyelinated fibers in the gastrocnemius ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91037-2
更新日期:1991-02-15 00:00:00
abstract::Two myelin sheaths sharing a common outer tongue process are illustrated in a thin section electron micrograph from mouse optic nerve. Although they derive from the same outer tongue process, and therefore from the same oligodendrocyte, the two sheaths are of different thicknesses (6 and 9 turns). The example demonstr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90712-6
更新日期:1983-09-12 00:00:00
abstract::A study of seizure activity and neuronal cell death produced by intracerebroventricular kainic acid had suggested that seizures conveyed by the hippocampal mossy fibers are more damaging to CA3 pyramidal cells than seizures conveyed by other pathways. To test this idea, the effects of a unilateral mossy fiber lesion w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91171-c
更新日期:1990-03-26 00:00:00
abstract::We previously reported that abdominal surgery induces Fos expression in specific hypothalamic and medullary nuclei and also causes gastric stasis. The gastric ileus is reduced by systemic capsaicin and abolished by central injection of corticotropin-releasing factor (CRF) antagonist. We studied the influence of system...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01281-4
更新日期:1997-02-14 00:00:00
abstract::The effects of estrus and prolonged estradiol benzoate (EB) treatment on estrogen receptor-like immunoreactivity (ER-LI) were studied in the female Brazilian opossum (monodelphis domestica) brain. In general, both estrus animals and EB treated animals had reduced ER-LI in specific brain regions when compared to ovarie...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90632-w
更新日期:1993-07-16 00:00:00
abstract::Alcohol-preferring Alko, Alcohol (AA) rats with free access to food and water were taught to voluntarily consume 10% alcohol solution during 20-min sessions. After the drinking session, rats had elevated dopamine release (as reflected by 3-methoxytyramine concentrations) in the nucleus accumbens, olfactory tubercle, a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)81705-2
更新日期:1997-11-07 00:00:00
abstract::We have previously demonstrated resiniferatoxin (RTX) to be an ultrapotent analog of capsaicin. Like capsaicin, RTX initially induces neurogenic inflammation, pain, and hypothermia and then causes desensitization of these responses. We examine here the duration of desensitization following acute treatment with the max...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91705-8
更新日期:1989-11-27 00:00:00
abstract::Measurement of histamine and its metabolizing enzymes in a variety of chordate species indicated that histamine and histamine methyltransferase were present in brain of all vertebrate species with a recognizable brain structure. Diamine oxidase was absent in mammalian brain but was present in brain of lower vertebrate...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90642-9
更新日期:1981-03-09 00:00:00
abstract::Spontaneous figure reversal of ambiguous patterns was analyzed in humans. A) With Necker-"cube"-like, or "drum"-like figures, having square or round shaped "front" and "rear" surfaces, and either large or small "depth", the perceptual intervals corresponding to both interpretations of "drum" were longer than those of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.04.064
更新日期:2008-08-15 00:00:00
abstract::Many lines of evidence support the importance of the nucleus accumbens (NAC) for ethanol-reinforced behavior. The nature of the neuronal activity that occurs in this region during ethanol self-administration is not known. We recorded from ensembles of single-units primarily located within the shell of the NAC during o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01245-1
更新日期:1999-01-30 00:00:00
abstract::Astrocytes produce and bind endothelins (ETs), suggesting that these cells have ET autoregulatory and eliminatory functions. To further investigate these functions in primary rat astrocytes, ET-1 levels in the cell culture media (RIA/HPLC) and intracellular content of ET-1 mRNA (RT PCR) were measured under basal and s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01368-1
更新日期:1998-03-02 00:00:00
abstract::The effect of monocular enucleation on basophilic and metabolic staining in primary (striate) visual cortex has been compared in Old and New World monkeys. Both species show a 30-40% shrinkage of neurons in the layers of dorsal lateral geniculate nucleus receiving axons from the enucleated eye. In striate cortex Old W...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91589-6
更新日期:1985-05-06 00:00:00
abstract::The horizontal and vertical vestibulo ocular reflex (VOR) of head tilted (het) mutant mice was compared to C57BL/6 controls. Eye movements were recorded in darkness using a temporarily attached search coil. Contributions of semicircular canal versus otolith organ signals were investigated by providing a canal only (ve...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02505-8
更新日期:2003-05-16 00:00:00
abstract::The dopaminergic regulation of prolactin (PRL) and growth hormone (GH) synthesis were studied in monolayer cultures of rat pituitary tumor (GH3) cells. PRL synthesis could not be inhibited by dopamine at concentrations ranging from 10(-9) to 10(-5) M. Bromocriptine inhibited PRL synthesis only at the very high concent...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90808-9
更新日期:1983-06-27 00:00:00
abstract::Calcium/calmodulin-dependent protein kinase II (kinase II) and protein phosphatase 2B (calcineurin) immunoreactivity in the rat hippocampus was studied 100 days after ischemic damage to hippocampal CA1 pyramidal neurons. One-hundred days after ischemia, only a few CA1 pyramidal neurons survived and they exhibited enha...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00382-z
更新日期:1995-06-26 00:00:00