Abstract：
:The axonal transport of radiolabeled slow phase proteins and fast phase glycoproteins was studied in rabbit hypoglossal nerve one week after axotomy. The nerves were ligated and cut to prevent axonal regeneration into the distal stump. In this situation of obstructed axonal outgrowth, the axonal transport of these components into the proximal part of the nerve was increased. This increase, however, was significantly less pronounced compared with the increase previously found after nerve crush, when the axons were free to regenerate. The results suggest that the axonal transport response concerning structural axonal proteins after nerve lesions depends on the type of trauma, and that the neuronal export of these components during regeneration is modified if axonal outgrowth is impaired. The results are discussed in the light of the present understanding of the role of axonal transport in nerve regeneration.
journal_name
Brain Resjournal_title
Brain researchauthors
Frizell Mdoi
10.1016/0006-8993(82)90953-2subject
Has Abstractpub_date
1982-10-28 00:00:00pages
65-9issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(82)90953-2journal_volume
250pub_type
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