The effect of electroacupuncture on proteomic changes in the motor cortex of 6-OHDA Parkinsonian rats.

Abstract:

:Electroacupuncture (EA) has been reported to alleviate motor deficits in Parkinson's disease (PD) patients, and PD animal models. However, the mechanisms by which EA improves motor function have not been investigated. We have employed a 6-hydroxydopamine (6-OHDA) unilateral injection induced PD model to investigate whether EA alters protein expression in the motor cortex. We found that 4weeks of EA treatment significantly improved spontaneous floor plane locomotion and rotarod performance. High-throughput proteomic analysis in the motor cortex was employed. The expression of 54 proteins were altered in the unlesioned motor cortex, and 102 protein expressions were altered in the lesioned motor cortex of 6-OHDA rats compared to sham rats. Compared to non-treatment PD control, EA treatment reversed 6 proteins in unlesioned and 19 proteins in lesioned motor cortex. The present study demonstrated that PD induces proteomic changes in the motor cortex, some of which are rescued by EA treatment. These targeted proteins were mainly involved in increasing autophagy, mRNA processing and ATP binding and maintaining the balance of neurotransmitters.

journal_name

Brain Res

journal_title

Brain research

authors

Li M,Li L,Wang K,Su W,Jia J,Wang X

doi

10.1016/j.brainres.2017.07.027

subject

Has Abstract

pub_date

2017-10-15 00:00:00

pages

52-63

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(17)30326-8

journal_volume

1673

pub_type

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