Abstract:
:Research supports the effectiveness of acupuncture for conditions such as chronic low back and knee pain. In a five-patient pilot study the modality also improved the symptoms of chemotherapy-induced neuropathic pain. Using an established rat model of paclitaxel-induced peripheral neuropathy, we evaluated the effect of electroacupuncture (EA) on paclitaxel-induced hyperalgesia and allodynia that has not been studied in an animal model. We hypothesize that EA would relieve the paclitaxel-induced mechanical allodynia and hyperalgesia, which was assessed 30 min after EA using von Frey filaments. Beginning on day 13, the response frequency to von Frey filaments (4-15 g) was significantly increased in paclitaxel-injected rats compared to those injected with vehicle. EA at 10 Hz significantly (P<0.05) decreased response frequency at 4-15 g compared to sham EA; EA at 100 Hz only decreased response frequency at 15 g stimulation. Compared to sham EA plus vehicle, EA at 10 Hz plus either a μ, δ, or κ opioid receptor antagonist did not significantly decrease mechanical response frequency, indicating that all three antagonists blocked EA inhibition of allodynia and hyperalgesia. Since we previously demonstrated that μ and δ but not κ opioid receptors affect EA anti-hyperalgesia in an inflammatory pain model, these data show that EA inhibits pain through different opioid receptors under varying conditions. Our data indicate that EA at 10 Hz inhibits mechanical allodynia/hyperalgesia more potently than does EA at 100 Hz. Thus, EA significantly inhibits paclitaxel-induced allodynia/hyperalgesia through spinal opioid receptors, and EA may be a useful complementary treatment for neuropathic pain patients.
journal_name
Brain Resjournal_title
Brain researchauthors
Meng X,Zhang Y,Li A,Xin J,Lao L,Ren K,Berman BM,Tan M,Zhang RXdoi
10.1016/j.brainres.2011.08.004subject
Has Abstractpub_date
2011-09-26 00:00:00pages
58-65eissn
0006-8993issn
1872-6240pii
S0006-8993(11)01440-5journal_volume
1414pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Two distinct patterns of terminal labeling were seen after injections of [3H]amino acids into the second somatosensory area (S2) and the retroinsular area (Ri). The first pattern, seen both in S2 after an injection in Ri and in the granular or dysgranular insular fields after an injection in S2, is characterized by he...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91103-4
更新日期:1983-08-22 00:00:00
abstract::Substance P (SP) and neurokinin A (NKA), two coexisting neuropeptides of the tachykinin family, stimulated the basal (5 mM K+) and evoked (40 mM K+) release of [3H]5-HT (5-hydroxytryptamine) from tissue slices of the rat cerebral cortex. Spantide ([DArg1,-DTrp7,9,Leu11]SP; 10(-5) M) inhibited the effects of SP but pot...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91275-l
更新日期:1990-01-08 00:00:00
abstract::Metabolic dysfunction in the relay nuclei of the rat vibrissa circuit follows traumatic brain injury (TBI). This study examined the effects of mild (1.4-1.5 atm) parasagittal fluid-percussion injury on the electrophysiology of this circuit. TBI caused significant reductions in slope and increases in latency of vibriss...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02424-6
更新日期:2001-06-15 00:00:00
abstract::The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (2...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01952-6
更新日期:1999-10-16 00:00:00
abstract::Many phosphorylated extracellular signal-regulated kinase (pERK)-immunoreactive (IR) cells are expressed in the trigeminal spinal subnucleus caudalis (Vc), upper cervical spinal cord (C1-C2), nucleus tractus solitarii (NTS) and paratrigeminal nucleus (Pa5) after capsaicin injection into the whisker pad (WP), masseter ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.08.032
更新日期:2011-10-12 00:00:00
abstract::Cerebellar explants derived from neonatal mice were exposed to cytosine arabinoside, an inhibitor of DNA synthesis. Following such exposure, the cortical regions of the explants contained numerous closely packed large neurons with few intervening elements and without lamination. The surviving large cortical neurons in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90984-1
更新日期:1980-03-31 00:00:00
abstract::Previous work has shown that administration of corticotropin-releasing factor (CRF) into the lateral ventricle antagonizes the orexigenic effect of neuropeptide Y (NPY), and central injection of CRF antagonist, alpha-helical CRF(9-41) enhanced NPY-induced food intake in satiated rats. The aim of the present study was ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90431-l
更新日期:1993-07-30 00:00:00
abstract::Some kinds of nociception appear to be partially mediated by the release of substance P (SP) in the spinal cord dorsal horn from terminals of primary afferent nociceptors. Only some nociceptors contain and release SP however. Specifically, SP appears to be released by unmyelinated (C) nociceptive afferents when activa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01466-7
更新日期:1997-03-28 00:00:00
abstract::Available evidence suggests that regular, moderate-intensity exercise has beneficial effects on neural health, perhaps including neuroprotection. To evaluate this idea further, we compared the severity of kainate-induced neuronal loss in exercised versus sedentary female rats. Stereological estimations of neuron numbe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02365-5
更新日期:2003-05-09 00:00:00
abstract::Adaptation in aging may become impaired from abnormal expression of corticotropin-releasing factor (CRF) and altered CRF receptor function. In this study, we measured CRF mRNA levels in Fischer 344 rats at various ages. The brains of these rats were processed for in situ hybridization. Relative to 3-month-old rats, le...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01365-1
更新日期:1999-03-20 00:00:00
abstract::Eye and head movements during tracking of a smoothly moving visual target were recorded in trained monkeys. The head movement clearly followed the target, although with considerable variability from cycle to cycle. The eye stayed relatively near the primary position and moved in an apparently irregular fashion; howeve...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)91127-7
更新日期:1978-09-15 00:00:00
abstract::Activities of individual, force-sensitive mechanoreceptors (funnel canal organs) of the terminal segment (dactyl) of the crab leg have been recorded in freely moving animals. During the stance phase of walking receptors discharge in regular bursts that are closely correlated with activity of the opener muscle of the p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90663-8
更新日期:1985-06-17 00:00:00
abstract::ENT1 is an equilibrative nucleoside transporter that enables trans-membrane bi-directional diffusion of biologically active purines such as adenosine. In spinal cord dorsal horn and in sensory afferent neurons, adenosine acts as a neuromodulator with complex pro- and anti-nociceptive actions. Although uptake and relea...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.08.017
更新日期:2005-10-19 00:00:00
abstract::The present study attempts to elucidate the possible role of adenosine 3',5'-monophosphate (cAMP) and prostaglandin E2 (PGE2) in the function of the neural luteinizing hormone-releasing hormone (LH-RH) apparatus. To this end, in vitro LH-RH release from superfused hypothalamic fragments and cAMP production by hypothal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90162-9
更新日期:1986-10-29 00:00:00
abstract::The carrier-mediated uptake of anionic and cationic amino acids by the basolateral face (blood side) of the isolated perfused sheep choroid plexus was demonstrated using the paired-tracer dilution technique. The uptake of these two classes of amino acid was higher than at the blood-brain barrier with no cross-competit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90731-n
更新日期:1992-05-29 00:00:00
abstract::Adult male guinea pigs were castrated and 24 h later injected with [3H]dihydrotestosterone. Their pituitary glands were then processed for autoradiographic and immunocytochemical analyses. Three percent of the parenchymal cells in the pars distalis were radiolabelled. These cells were primarily gonadotrophs; a small p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90456-7
更新日期:1986-01-08 00:00:00
abstract::The distribution of substance P (SP) immunoreactivity in the spinal nucleus of the rat trigeminal nerve and in the skin of the lower lip was examined following (a) unilateral electrolytic lesions of the trigeminal ganglion, (b) trigeminal rhizotomy, and (c) unilateral interruption of the mental nerve, the sensory bran...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)91105-8
更新日期:1978-09-08 00:00:00
abstract::Ibogaine, an indolalkylamine, has been proposed for use in treating stimulant addiction. In the present study we sought to determine if ibogaine had any effects on the neurochemical and motor changes induced by D-amphetamine that would substantiate the anti-addictive claim. Ibogaine (40 mg/kg, i.p.) injected 19 h prio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90745-u
更新日期:1992-05-01 00:00:00
abstract::Sodium and potassium currents in the node of Ranvier decrease exponentially with time during long lasting voltage clamp experiments. This decline is strongly dependent on temperature (Q10 approximately 3). Thiamine and, particularly, its diand triphosphoric acid esters are shown to prevent this exponential decline of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90720-9
更新日期:1975-05-23 00:00:00
abstract::Chronically demyelinated lesions of cat dorsal columns were created by focal injection of the glial toxin ethidium bromide. Freeze-fracture studies show that the center of the lesion, which is devoid of glial cells and processes, contains axons having neither node-like nor paranodal-type membrane specializations. Near...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90973-4
更新日期:1985-12-09 00:00:00
abstract::To elucidate the anatomical distribution of the serotonergic neurotransmitter system, we identified serotonin transporter (5-HTT) in the hippocampus of rats and monkeys by immunohistochemistry. A widespread and heterogeneous distribution of 5-HTT-immunoreactive fine fibers was noted in the rat brain. However, in monke...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.03.013
更新日期:2004-06-04 00:00:00
abstract::Experiments were performed in the male Wistar rat to investigate the projections from cardiovascular responsive sites in the ventrolateral medulla (VLM) to the subfornical organ (SFO). Unilateral iontophoretic injections of Phaseolus vulgaris leucoagglutinin (PHA-L) were made into either caudal VLM (CVLM) sites at whi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.12.029
更新日期:2004-04-02 00:00:00
abstract::Heme oxygenase-carbon monoxide-cGMP (HO-CO-cGMP) pathway has been reported to be involved in peripheral and spinal modulation of inflammatory pain. However, the involvement of this pathway in the modulation of acute painful stimulus in the absence of inflammation remains unknown. Thus, we evaluated the involvement of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.02.044
更新日期:2011-04-18 00:00:00
abstract::Neural plasticity of afferent pain pathways that is induced by prolonged or repeated noxious stimuli may contribute to activate intrinsic inhibitory mechanisms in CNS. In order to clarify the role of the monoaminergic descending inhibitory system in acute nociception and inflammatory pain, we examined if this inhibito...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01086-5
更新日期:1998-12-14 00:00:00
abstract::The neurotoxin alpha-latrotoxin elicits spontaneous exocytosis of neurotransmitter from neurons and peptide hormones from endocrine cells. While the mechanism of action is not fully understood, both Ca(2+)-dependent and Ca(2+)-independent pathways participate in the facilitation of release, with the relative contribut...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.08.025
更新日期:2003-11-28 00:00:00
abstract::The ionic mechanism of the membrane permeability changes caused by L-glutamate in hippocampal neurons prepared from 17- to 19-day-old fetal rat in dispersed cell cultures was studied with the whole-cell variation of the patch electrode voltage-clamp technique. The cultured hippocampal neurons became sensitive to gluta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91601-0
更新日期:1988-03-08 00:00:00
abstract::Investigations of the time course of various stages of lexical processing have indicated either early or late onset of brain activation for phonological code retrieval. The basis of the differential findings is unclear, but factors related to segmental phonology appear to be part of it. The purpose of the present stud...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.01.014
更新日期:2016-03-15 00:00:00
abstract::Freeze-fracture examination of nodes of Ranvier from adult rat optic nerve demonstrates the presence of astrocytic processes at the majority of nodes of Ranvier. Astrocytic processes often run along the entire length of the nodal gap, although they do not necessarily encircle the entire nodal circumference. The E- and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90919-3
更新日期:1984-08-06 00:00:00
abstract:BACKGROUND:Perinatal brain injury in preterm infants is a major cause of neurological handicap. The role of the neurotrophin receptor p75 (p75(NTR)) in the pathogenesis and repair of neonatal excitotoxic brain injury is unknown. Depending on a complex interplay of neurotrophin signalling, p75(NTR) can, in addition to i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.07.095
更新日期:2010-10-08 00:00:00
abstract::The brain contains neurons which alter their firing rates when ambient glucose concentrations change. An ATP-sensitive K+ (Katp) channel on these neurons closes and increases cell firing when ATP is produced by intracellular glucose metabolism. Binding of the antidiabetic sulfonylurea drugs to a site linked to this ch...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00835-9
更新日期:1996-11-11 00:00:00