Abstract:
:To elucidate the anatomical distribution of the serotonergic neurotransmitter system, we identified serotonin transporter (5-HTT) in the hippocampus of rats and monkeys by immunohistochemistry. A widespread and heterogeneous distribution of 5-HTT-immunoreactive fine fibers was noted in the rat brain. However, in monkeys, punctuate 5-HTT-immunoreactive deposits and fewer fibers were observed. The species difference in 5-HTT immunohistochemical staining pattern may be caused by differences in localization of 5-HTT between species.
journal_name
Brain Resjournal_title
Brain researchauthors
Owashi T,Iritani S,Niizato K,Ikeda K,Kamijima Kdoi
10.1016/j.brainres.2004.03.013subject
Has Abstractpub_date
2004-06-04 00:00:00pages
166-8issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899304004330journal_volume
1010pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The possibility that the opioid delta-receptor mediates antinociception in tests where heat is the noxious stimulus was investigated using highly selective mu- and delta-agonist and -antagonists. Antinociceptive dose-response curves were constructed for mu ([D-Ala2,NMePhe4,Gly-ol]enkephalin, DAGO; morphine) and delta ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90244-7
更新日期:1987-09-08 00:00:00
abstract::The distribution of nitric oxide synthase (NOS)-, choline acetyltransferase (ChAT)-, and vasoactive intestinal polypeptide (VIP)-immunoreactivities, and nicotinamide adenine dinucleotide phosphate diaphorase (NADPHd)-reactivities in the sphenopalatine ganglia (SPG), and perivascular nerves in middle cerebral arteries ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00548-4
更新日期:1998-08-10 00:00:00
abstract::Administration of vitamin B12 (VB12) has been reported to normalize human sleep-wake rhythm disorders such as non-24-h sleep-wake syndrome (HNS), delayed sleep phase syndrome (DSPS) or insomnia. However, the mechanisms of the action of VB12 on the rhythm disorders are unknown. In the present study, therefore, effects ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00349-6
更新日期:1996-07-15 00:00:00
abstract::Extracellular recordings of action potentials were made from neurones antidromically identified as neurosecretory cells in the paraventricular and supraoptic nuclei of urethane-anesthetized female rats. Eighty-six neurones were examined for their responsiveness to 10 ng of angiotensin II (AII) injected into the third ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90048-7
更新日期:1980-04-28 00:00:00
abstract::The present study investigated the antidepressant potential of curcumin in olfactory bulbectomy and forced swimming test models of depression in male albino rats under chronic treatment. The experimental animals were divided into four groups, and curcumin was administered for 45 days. Our results showed that the curcu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.03.010
更新日期:2016-07-01 00:00:00
abstract::Rats were first trained to acquire an olfactory discrimination learning set (ODLS) on 40 olfactory-unique discrimination problems. Following acquisition of ODLS, animals were lesioned bilaterally in the nucleus basalis magnocellularis (nBM) using either quisqualic acid (QUIS) or 192 IgG-saporin (SAP). QUIS animals per...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.12.028
更新日期:2007-03-09 00:00:00
abstract::Porcine calcitonin (pCT) encapsulated in sulfatide-containing reverse-phase evaporation vesicles (REVs) was shown to induce long-lasting and dose-dependent antinociceptive effect by systemic injection in mice. Its antinociceptive activity is found to be dependent on the route of administration. In contrast, neither un...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91311-f
更新日期:1993-02-12 00:00:00
abstract::Mice with reduced expression of the NR1 subunit of the NMDA receptor (NR1 hypomorphic mice) display altered behavioral phenotypes that may relate to behavioral characteristics of schizophrenia. Altered phenotypes in the NR1 hypomorphs include marked deficits in species-typical behavioral interactions in tests of socia...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.02.002
更新日期:2009-04-10 00:00:00
abstract::Immunohistochemical localization of brain-derived neurotrophic factor (BDNF) in the monkey brain was investigated using a polyclonal anti-BDNF antibody produced in our laboratory. The antibody recognized a single band in monkey brain homogenates, and the estimated molecular weight was approximately 14 kDa, which corre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01082-3
更新日期:1999-03-13 00:00:00
abstract::The present study was designed to examine the trophic effect of sympathetic nerves on cerebrovascular hypertrophy in developmental hypertension. Unilateral superior cervical ganglionectomy was performed in spontaneously hypertensive rats at 4 weeks of age, and wall-to-lumen ratios of cerebral arteries were determined ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90772-9
更新日期:1986-08-06 00:00:00
abstract::Prolonged seizures have long been known to be associated with cell injury and cell death in brain. Such seizure-related neuronal injury has been assumed to be mediated by glutamate, the same excitatory amino acid in the central nervous system which propagates the seizure itself. Elevated extracellular concentrations o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00658-0
更新日期:1996-10-21 00:00:00
abstract::Erythropoietin (EPO) provides neuroprotection and neurorestoration after traumatic brain injury (TBI). The EPO doses used for treatment of TBI significantly increase hematocrit, which may affect the efficacy of EPO therapy for TBI. The aim of this study was to investigate whether normalization of hematocrit would affe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.07.077
更新日期:2009-10-19 00:00:00
abstract::This study analyzed the effects of pre-existing hyperglycemia on the extracellular levels of glutamate, other amino acids and free fatty acids, including arachidonic acid, in the ischemic/reperfused rat cerebral cortex, using a cortical cup technique. Forebrain cerebral ischemia (20 min) was induced by four vessel occ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01700-x
更新日期:1999-08-07 00:00:00
abstract::The A-ring reduced metabolite of deoxycorticosterone, 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone (THDOC) was recently shown to act at the gamma-aminobutyric acid receptor-chloride ion channel complex in rat brain. The behavioral profile of THDOC was investigated using two animal models of anxiety, the two-chambere...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91500-3
更新日期:1986-11-29 00:00:00
abstract::The mechanism of 3,4-methylenedioxymethamphetamine (d-MDMA)-induced neurotoxicity may involve formation of toxic radical species. Endogenous defenses against toxic radical species include tissue stores of vitamin E, and thiols. We examined whether vitamin E deficiency could alter d-MDMA-induced neurotoxicity by admini...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02313-2
更新日期:2002-04-19 00:00:00
abstract::The characteristics of [3H]sulpiride binding to the D2 dopamine receptor in rat striatal membranes were examined under several conditions. In the absence of sodium ions, the specific binding of [3H]sulpiride could not be detected. In the direct binding experiment, at 25 degrees C, the affinity of [3H]sulpiride for D2 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90040-0
更新日期:1987-02-03 00:00:00
abstract::Electrical stimulation of the brain, particularly in the periventricular grey areas, caused long-lasting increases in behavioural escape thresholds to heating and mechanical stimuli applied to the facial region of the rat. The brain stimulation selectively suppressed responses to noxious stimuli. Responses to non-noxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00927-i
更新日期:1995-11-27 00:00:00
abstract::In the course of pulse-label studies on the axonal transport of the small, basic, actin-binding proteins--actin depolymerizing factor, cofilin and profilin--in chicken motor neurones, we observed a heavily labelled protein of M(r) 18 kDa and pI 8.2 on fluorographs of two-dimensional polyacrylamide gels. On the basis o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00766-x
更新日期:1997-10-17 00:00:00
abstract::Thermoregulation is a complex intercommunicative function requiring coordination between core body temperature (CBT), the central nervous system, and peripheral vasculature. In menopausal women, dysregulation of thermoregulatory mechanisms leads to hot flushes and night sweats. A previous study in ovariectomized (OVX)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.09.050
更新日期:2006-12-06 00:00:00
abstract:OBJECTIVE:Previously, we found that the inhaled anesthetic isoflurane up-regulated the transcriptional factor hypoxia inducible factor (HIF)-1α protein levels during induction of neurodegeneration in the brain of neonatal rats. Here, we investigated the role of HIF-1α and the underlying signaling pathway in the neurode...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.10.014
更新日期:2016-12-15 00:00:00
abstract::CNS inflammation is a sequela of a variety of neuropathological conditions resulting in extensive tissue loss. Inflammation is mediated primarily by phagocytic cells, but the mechanisms of CNS tissue destruction are not fully understood. Hypochlorous acid (HOCl) is by far the most abundant agent generated by phagocyti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.09.080
更新日期:2004-02-06 00:00:00
abstract::Many of our everyday actions are only appropriate in certain situations and selecting the appropriate behavior requires that we use current context and previous experience to guide our decisions. The current study examined hippocampal functional connectivity with prefrontal and striatal regions during a task that requ...
journal_title:Brain research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.brainres.2011.09.038
更新日期:2011-11-14 00:00:00
abstract::A substantial number of patients do not respond sufficiently to antidepressant drugs and are therefore often co-medicated with lithium as an augmentative strategy. Since lithium has been demonstrated to affect 5-HT neurotransmission, we examined the effect of acute and subchronic lithium on 5-HT levels after a challen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02461-6
更新日期:2000-07-21 00:00:00
abstract::Oa1 is the casual gene for ocular albinism-1 in humans. The gene product OA1, alternatively designated as GPR143, belongs to G-protein coupled receptors. It has been reported that OA1 is a specific receptor for 3, 4-dihydroxy- L-phenylalanine (DOPA) in retinal pigmental epithelium where DOPA facilitates the pigmentati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.01.020
更新日期:2015-03-30 00:00:00
abstract::Gonadal steroids have previously been shown to enhance neuritic outgrowth from mouse preoptic area explants in vitro. To examine effects within the explant proper, dendritic fields of Golgi-stained neurons of estradiol-treated and untreated cultures were compared quantitatively. Neurons of gonadal steroid-treated cult...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90085-8
更新日期:1983-03-01 00:00:00
abstract::Primary afferent neurons in mammalian dorsal root ganglia (DRGs) normally function as independent sensory communication elements. However, it has recently been shown that most DRG neurons are transiently activated when axons of neighboring neurons of the same ganglion are stimulated repetitively and the cross-depolari...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02342-4
更新日期:2003-04-25 00:00:00
abstract::The effect of aging on the properties of N-methyl-D-aspartate (NMDA) receptors in the forebrain of female NMRI mice was investigated using the antagonist [3H]MK-801 as radioligand. Compared to young (3 months) mice, aged (20 months) mice showed changes of the properties of the NMDA receptor at three different levels: ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90892-d
更新日期:1992-07-03 00:00:00
abstract::Intraocular injections of ethylcholine mustard aziridinium ion (AF64A) in the rat depressed retinal choline acetyltransferase (ChAT) activity in a dose-dependent manner without any significant change in the content of amino acid neurotransmitters GABA, glycine, aspartate and glutamate. ChAT reduction was already detec...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91466-7
更新日期:1988-01-26 00:00:00
abstract::The 2,3-benzodiazepine derivative GYKI 52466 has been well characterized as a negative modulator of AMPA-type glutamate receptors. The present study re-examined the effects of GYKI 52466 on AMPA receptor-mediated currents in patches excised from pyramidal neurons in the hippocampal CA1 field and found that this drug h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03323-0
更新日期:2001-02-23 00:00:00
abstract::Previous studies showed the role of basolateral amygdala (BLA) in cannabinoid-induced antinociception. Furthermore, the nucleus accumbens (NAc) plays an important role in mediating the suppression of pain in animal models. The present study extended the role of dopamine receptors within the NAc in antinociceptive effe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.06.023
更新日期:2012-08-30 00:00:00