Abstract：
:The present study was designed to examine the trophic effect of sympathetic nerves on cerebrovascular hypertrophy in developmental hypertension. Unilateral superior cervical ganglionectomy was performed in spontaneously hypertensive rats at 4 weeks of age, and wall-to-lumen ratios of cerebral arteries were determined at 5 weeks, 2 months or 5 months after denervation. To estimate the thickness of the vessel wall, a freeze substitution technique was used for the preparation of cerebral arteries. Basal mean arterial blood pressure measured through cannulated femoral artery was 127 +/- 2, 146 +/- 7 and 168 +/- 6 mm Hg (mean +/- S.E.M.) at 9 weeks, 3 months and 6 months of age, respectively. The wall-to-lumen ratios in the denervated and innervated hemispheres were 0.124 +/- 0.004 and 0.129 +/- 0.005 at 9 weeks, 0.127 +/- 0.003 and 0.169 +/- 0.004 (P less than 0.02 vs denervated) at 3 months, and 0.194 +/- 0.007 and 0.222 +/- 0.006 (P less than 0.05 vs denervated) at 6 months. The effect of denervation was more significant in downstream vessels (diameter less than or equal to 100 microns) than larger ones. We conclude that wall-to-lumen ratio is correlated well with a rise in basal blood pressure, and chronic interruption of the sympathetic nerves attenuates normal occurrence of vascular hypertrophy during the development of hypertension.
journal_name
Brain Resjournal_title
Brain researchauthors
Sadoshima S,Fujii K,Yao H,Ibayashi S,Fujishima Mdoi
10.1016/0006-8993(86)90772-9subject
Has Abstractpub_date
1986-08-06 00:00:00pages
205-9issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(86)90772-9journal_volume
379pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The effect of high acetaldehyde (ACe) on acetylcholine (ACh) release was studied in vivo in the medial frontal cortex (mfc) of freely moving rats using brain microdialysis coupled with high performance liquid chromatography and an electrochemical detector. Ethanol (EtOH) and ACe concentrations were quantified simultan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.01.049
更新日期：2005-03-28 00:00:00
abstract：:Numerous studies have suggested that nitric oxide (NO) in the nucleus tractus solitarii (NTS) participates in modulating cardiovascular function. Nitric oxide synthase (NOS), the enzyme responsible for synthesis of NO, exists in 3 isoforms: endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS (iNOS). Althoug...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.057
更新日期：2007-09-26 00:00:00
abstract：:Whereas the role of the hippocampus for spatial learning and long-term memory is largely undisputed, there is less evidence for a participation of hippocampal structures in spatial working memory operations. In an fMRI study (functional magnetic resonance imaging), we therefore examined the role of the hippocampus dur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.07.065
更新日期：2010-10-01 00:00:00
abstract：:Prostaglandins are now thought to play an important role in nociceptive information transmission in the spinal cord. Prostaglandins are known to be produced by cyclooxygenase (COX), which catalyzes the conversion of arachidonic acid. Two forms of COX have been identified: COX-1, which is constitutively expressed in mo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00817-7
更新日期：1996-11-11 00:00:00
abstract：:Tyrosine hydroxylase immunohistochemical analysis was performed on tissue sections through the pallidal complex from Nemistrina monkeys which had been made hemi-parkinsonian by intracarotid MPTP infusion 8-12 months earlier. The side contralateral to the MPTP infusion showed a dense dopaminergic innervation of the pal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90318-p
更新日期：1991-08-16 00:00:00
abstract：:Neonatal hypoxia-ischemia (HI) has been extensively studied in a rat model characterized by unilateral brain damage (Rice-Vannucci Model). However, as well as in humans, each rat brain hemisphere is distinctly involved in cognitive functions, as for example retrieval of emotionally based memory, and neurochemical asym...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02436-3
更新日期：2003-05-30 00:00:00
abstract：:Locally applied ciliary neurotrophic factor (CNTF) has a powerful effect on retrograde axonal reaction following facial nerve crush in neonatal rats. We examined whether it also exerts a strong effect on retrograde axonal reaction in young adult rats when administered subcutaneously. The dose was 1 mg/kg body weight, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01512-4
更新日期：1996-04-22 00:00:00
abstract：:The periaqueductal gray matter (PAG) has been implicated in a variety of different functions, including autonomic regulation. Chemical stimulation of the lateral PAG produces hypertension and tachycardia while activation of the ventrolateral PAG produces the opposite effect. While these effects are the result of alter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00592-1
更新日期：1997-08-01 00:00:00
abstract：:Respiration related units ( RRU ) were recorded in the brainstem of cats with spinal transection at the C7-Th 1 level and breathing N2O. The proportion of RRU in several structures was compared in control and in 3 experimental groups: (1) paralyzed with gallamine triethiodide; (2) vagotomized; and (3) both vagotomized...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90790-x
更新日期：1984-05-07 00:00:00
abstract：:Previous work has shown a relatively high turnover of adrenaline in the mediobasal hypothalamus during the critical period (15.00-17.00 h) of the proestrous rat. We now report that this high level of adrenergic activity can be detected in the median eminence (turnover rate 1.62 +/- 0.36 pg/micrograms protein/h) rather...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90307-x
更新日期：1984-12-10 00:00:00
abstract：:Epileptic discharge patterns in an acute experimental model of epilepsy were analyzed. Epileptic foci were induced by epicortical application of penicillin on the rat motor cortex in vivo. Patterns with regular 1/s discharges, patterns with irregular discharges of about 0.5/s as well as compound patterns comprising di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90221-8
更新日期：1993-07-09 00:00:00
abstract：:Microspectrofluorimetric measurements of excitatory amino acid-evoked rises in intracellular free calcium concentration ([Ca2+]i), electrophysiological measurements of currents through single NMDA receptor-operated ion channels and estimates of cellular viability following NMDA challenge were employed to examine the i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00771-h
更新日期：1995-11-06 00:00:00
abstract：:Horseradish peroxidase injections into the medulla of tadpoles demonstrate, by back-filling, efferent neurons in the torus semicircularis which project to the ipsilateral superior olive. This projection, as well as one to the vicinity of the efferent neurons of the contralateral VIII and lateral line nerves, is confir...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90774-1
更新日期：1984-02-06 00:00:00
abstract：:Neurons in the polymorph layer of the hippocampal dentate hilus were found to be the cells of origin for ipsilateral association and commissural projections to the dentate gyrus. Both afferent systems terminate in the proximal one-third of the stratum moleculare. The polymorph layer is the primary target for noradrene...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90512-6
更新日期：1981-06-29 00:00:00
abstract：:We examined the effect of CP-154,526 on cardiovascular changes elicited in conscious rabbits by stressful stimuli (loud sound, cage move, pinprick, formaldehyde vapour and air-jet stress). CP-154,526 substantially reduced pressor and heart rate responses to these stimuli (both vagally and sympathetically mediated), an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.05.062
更新日期：2004-08-13 00:00:00
abstract：:Stimulation of a region within the parvocellular medullary reticular formation (PcRF) that contains somas of premotor interneurons produces short latency inhibitory synaptic potentials (IPSPs) in cat trigeminal motoneurons. The present study was undertaken to determine whether glycinergic synapses are responsible for ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90818-g
更新日期：1991-12-20 00:00:00
abstract：:Transient global cerebral ischemia has been shown to induce marked changes in the polyamine pathway with a significant increase in putrescine, the product of the ornithine decarboxylase reaction. This study examined the relationship between tissue and extracellular polyamines and regional cerebral blood flow and brain...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/S0006-8993(96)01116-X
更新日期：1997-01-09 00:00:00
abstract：:The effect of different steady-state cocaine concentration maintenance on the microdialysis extraction fraction of cocaine (in situ recovery; Ed) in the medial prefrontal cortex (mPFC) was examined. Male, adult Sprague-Dawley rats anesthetized with chloral hydrate were used. All rats were randomly divided into three g...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00456-z
更新日期：1995-07-24 00:00:00
abstract：:The right wingbuds of stage 23-25 chick embryos were amputated at the future elbow region and a segment of 2-day neural tube was implanted longitudinally into the limb stump of experimental embryos to induce limb regeneration. Control embryos had no implant in the amputated limb stump. To analyze effects of the neural...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90196-8
更新日期：1985-04-01 00:00:00
abstract：:Post-traumatic invasion of macrophages into the cochlear nerve of the rat and measurement of how their invasion was modified by the administration of methylprednisolone were investigated for the first time by using a reproducible and quantifiable experimental model of cochlear nerve injury. Two weeks after precise coc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02523-9
更新日期：2001-06-29 00:00:00
abstract：:Stereotaxically placed intracerebral microinjections of 6-hydroxydopamine (6-OHDA) were used to produce selective and extensive lesions of either the dopaminergic nigro-neostriatal bundle or the dorsal and ventral noradrenergic projections in the rat. The extensive damage of the noradrenergic pathways which is typical...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90182-1
更新日期：1975-08-15 00:00:00
abstract：:Frequency-modulated (FM) sweeps are important components of most natural sounds. To examine the processing of these stimuli we applied a two-tone paradigm. Repeated stimulus presentation usually leads to reduced neuronal responses. However, in a former study repetition enhancements which have been observed when FM ton...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.07.009
更新日期：2011-09-09 00:00:00
abstract：:Seventy-two hybridoma lines that produce monoclonal antibodies to molecules of a rat synaptosomal plasma membrane fraction (SPM) were generated. The topographical distribution of the antigens in the cerebellum and other areas of the brain was studied by light microscopy immunocytochemistry. Some of the antibodies reco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90118-5
更新日期：1984-11-26 00:00:00
abstract：:Pro-social lying, which serves to benefit listeners, is considered more socially and morally acceptable than anti-social lying, which serves to harm listeners. However, it is still unclear whether the neural mechanisms underlying the moral judgment of pro-social lying differ from those underlying the moral judgment of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.02.011
更新日期：2014-03-27 00:00:00
abstract：:Recently it has been reported that prolactin (PRL) exerts a neuroprotective effect against excitotoxicity in hippocampus in the rat in vivo models. However, the exact mechanism by which PRL mediates this effect is not completely understood. The aim of our study was to assess whether prolactin exerts neuroprotection ag...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.02.011
更新日期：2016-04-01 00:00:00
abstract：:Horseradish peroxidase (HRP) was used as a retrograde tracer to identify the distribution pattern of labeled cells in the inferior olivary nucleus (IO) of Tupaia. Crystallized HRP was implanted into dorsal (DPML) and ventral (VPML) divisions of the paramedian lobule (PML) and, following appropriate survival times, the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90433-5
更新日期：1984-07-09 00:00:00
abstract：:The immunohistochemical localization of an endogenous lectin R1 isolated from the rat cerebellum was studied during its postnatal development. The lectin is present in the cerebellum from birth to adulthood, essentially in lysosomes, multivesicular bodies, and parts of the endoplasmic reticulum, principally of large a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90148-8
更新日期：1985-01-01 00:00:00
abstract：:Transependymal absorption of cerebrospinal fluid (CSF) in hydrocephalus is suggested by periventricular edema, but the necessary bulk flow of interstitial fluid (ISF) has not been found. We performed ventriculocisternal perfusions in adult cats using CSF with the extracellular marker [3H]sucrose. CSF pressure was main...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90616-3
更新日期：1982-01-28 00:00:00
abstract：:Serotoninergic transmission is implicated in the photic and non-photic regulation of circadian rhythms. 5-HT (1-100 microM), carboxamidotryptamine (5-CT 0.1-10 microM) and (+)-8-hydroxy-dipropylaminotetraline (8-OH-DPAT, 1-30 microM) dose-dependently activated an outward current (5-100 pA) in 30% of neurons voltage-cl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02294-0
更新日期：2000-06-02 00:00:00
abstract：:The production and localization of cell-associated forms of beta-amyloid precursor protein (APP) of Alzheimer's disease was investigated in primary cultures of mouse glial cells. In both oligodendrocytes and astrocytes, immunofluorescence staining with an antibody against the carboxy terminus of APP revealed an intens...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90898-j
更新日期：1992-07-03 00:00:00
