Abstract：
:Tyrosine hydroxylase immunohistochemical analysis was performed on tissue sections through the pallidal complex from Nemistrina monkeys which had been made hemi-parkinsonian by intracarotid MPTP infusion 8-12 months earlier. The side contralateral to the MPTP infusion showed a dense dopaminergic innervation of the pallidum (both internal and external segments), but particularly the internal pallidum. The side of the brain ipsilateral to the MPTP infusion showed a remarkable sparing of the pallidal dopaminergic innervation, despite almost total loss of the dopaminergic innervation of the caudate and putamen. These results support the view that in the primate, the nigropallidal projection is mostly distinct from the nigrostriatal projection. It is also suggested that perhaps the sparing of pallidal dopamine at least in part may contribute to some of the recovery of function observed in some monkeys following exposure to MPTP.
journal_name
Brain Resjournal_title
Brain researchauthors
Schneider JS,Dacko Sdoi
10.1016/0006-8993(91)90318-psubject
Has Abstractpub_date
1991-08-16 00:00:00pages
292-6issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(91)90318-Pjournal_volume
556pub_type
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