Abstract:
:Administration of sheep red blood cells (10(6) cells, i.p.) resulted in central norepinephrine (NE) and dopamine (DA) changes which corresponded with the time of the peak immune response. These amine variations, however, appeared to be specific to certain brain regions. The increased accumulation of the NE metabolite, 3-methoxy-4-hydroxyphenylethylene glycol, was evident in hypothalamus, locus coeruleus and hippocampus and a moderate reduction of NE was evident in the hypothalamus. Alterations of DA levels or utilization appeared in mesocorticolimbic structures (i.e. nucleus accumbens and prefrontal cortex) but not in striatum. This profile of transmitter changes was reminiscent of that previously shown to be induced by uncontrollable stressors and the possibility was offered that antigenic challenge is interpreted as a stressor by the central nervous system.
journal_name
Brain Resjournal_title
Brain researchauthors
Zalcman S,Shanks N,Anisman Hdoi
10.1016/0006-8993(91)90117-esubject
Has Abstractpub_date
1991-08-23 00:00:00pages
69-76issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(91)90117-Ejournal_volume
557pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::We have recently reported spinal blood flow-metabolism uncoupling in an amyotrophic lateral sclerosis (ALS) animal model using Cu/Zn-superoxide dismutase 1 (SOD1)-transgenic (Tg) mice, suggesting a relative hypoxia in the spinal cord. However, the hypoxic stress sensor pathway has not been well studied in ALS. Here, w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.07.040
更新日期:2012-09-14 00:00:00
abstract::The regulatory role of endothelins in cerebral microvessels was investigated in a recently developed model system which allows the study of small cerebral vessels in their normal microenvironment. Using brain slices of the rat neocortex, it was shown that the isopeptide endothelin-3 (ET-3) had no effect on cerebral mi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(09)90024-5
更新日期:1994-09-26 00:00:00
abstract::The aim of this study was to test the role of the perifornical hypothalamus and adjacent areas in the behavioral and cardiovascular responses to two forms of stress, conditioned fear to context and restraint. Of particular interest was the role of the hypocretin (orexin) containing neurons in these responses. Rats imp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.10.058
更新日期:2007-01-12 00:00:00
abstract::Positron emission tomography, using the dopa analogue [18F]6-fluoro-L-dopa, has been used to depict the neostriatum in living monkeys. The amount of 18F that accumulated preferentially in the striatum could be augmented by a peripheral decarboxylase inhibitor. Striatal 18F could also be discharged with reserpine. This...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91187-3
更新日期:1983-11-28 00:00:00
abstract::Morphine is one of the most potent analgesics used in medicine and it's long-term use is associated with the risk of the state of dependence. The cessation of chronic morphine administration leads to withdrawal signs which are associated with neurotransmitter dysregulations within mesolimbic system. Adenosine 5'-triph...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.05.025
更新日期:2019-09-15 00:00:00
abstract::Calretinin has been identified as a brain specific calcium-binding protein which appears as a prominent protein in the cochlear nucleus. We identified and localized calretinin in the guinea pig and rat inner ear using polyclonal antibodies. Immunoblot analyses of guinea pig and rat auditory nerve homogenates revealed ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91224-o
更新日期:1991-09-27 00:00:00
abstract::The influence of the cortico-geniculate pathway on identified X and Y lateral geniculate cells was studied by reversibly cooling visual cortical areas 17 and 18. The majority (86.5%) of cells changed their response to visual stimulation when cortex was inactivated, and both X- and Y-cells were modulated by the cortica...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90568-0
更新日期:1981-03-16 00:00:00
abstract::The cholinergic presynaptic terminals of Torpedo electric organ have been examined morphometrically following stimulation by KCI and sucrose. The objective was to confirm correlations predicted by the vesicle hypothesis between miniature end-plate potentials (MEPPs) and morphometric changes in terminal ultrastructure....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00109-1
更新日期:1997-04-25 00:00:00
abstract::Aromatization of testosterone in the preoptic area of the male ring dove is required for the expression of specific estrogen-sensitive sexual behavior. Estradiol metabolism and/or binding of the aromatization product(s) to the preoptic estrogen receptors (ER) could interfere with the apparent increase in estradiol for...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90203-5
更新日期:1989-02-20 00:00:00
abstract::Murine spinal cord primary mixed cultures were treated with the respiratory inhibitor, rotenone, to mimic hypoxic conditions. Under these conditions neurons rapidly underwent oncosis (necrosis) with a complete loss in viability occurring within 260 min; however, astrocytes, which accounted for most of the cell populat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01086-0
更新日期:1999-03-13 00:00:00
abstract::Earlier studies showed that pretreatment (3 and 6 h) of rats with the glucocorticoid hormone, dexamethasone, potentiated the drinking response to either central or peripheral administration of angiotensin II (AII). In the present study the specificity and mechanisms of this potentiation were examined. Intraperitoneal ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90093-b
更新日期:1991-06-28 00:00:00
abstract::Although the role of cAMP-response-element-binding protein (CREB) binding protein (CBP) in the neuroprotective mechanisms has been the focus of many studies, very little is known about the expression or function of CBP in aged brains. We have therefore examined age-related changes in CBP expression in the cerebral cor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03562-x
更新日期:2002-11-29 00:00:00
abstract::Visual spatial orienting of attention towards exogenous cues has been one of the attentional functions considered to be spared in ADHD. Here we present a design in which 60 (30 ADHD) children, age: 10.9±1.4, were asked to covertly orient their attention to one or two (out of four) cued locations, and search for a targ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.11.036
更新日期:2013-02-01 00:00:00
abstract::The acute intravenous administration of high doses of methylprednisolone sodium succinate (15-90 mg/kg) to cats enhanced (Na+ + K+)-ATPase activity as much as 2-fold in synaptosomes prepared from lumbar spinal cord removed following drug administration. The effect was apparent within 5 min and was statistically signif...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90311-5
更新日期:1981-08-31 00:00:00
abstract::Unilateral olfactory nerve section was performed in the mouse. Three biochemical markers of the olfactory chemoreceptor neurons: carnosine, carnosine synthetase activity and the olfactory marker protein, were measured in the olfactory bulb and epithelium. Parallel observations were made by light microscopy as well as ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90703-x
更新日期:1977-08-19 00:00:00
abstract::The GABAB agonist, baclofen, causes a dose-dependent decrease in lordosis, and this effect is attenuated following hypothalamic serotonin, (5-HT) lesions. Baclofen administration is associated with decreased 5-HT activity in the medial preoptic (mPOA) and ventromedial nuclei and enhanced 5-HT activity in the midbrain ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90564-c
更新日期:1991-08-09 00:00:00
abstract::The effect of stimulating the dorsal raphe nucleus (DRN) on the activity of single relay neurons in the dorsal lateral geniculate nucleus (LGNd) was studied in rats anesthetized with urethane. The position of stimulating electrodes was confirmed on histological sections processed with NADPH-diaphorase histochemistry w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90002-4
更新日期:1989-06-05 00:00:00
abstract::Using the hippocampal slice preparation, extracellular recordings of CA3 field excitatory postsynaptic potentials (fEPSPs) were performed to assess the effects of adenosine on the induction of mossy fiber long-term potentiation (LTP). When present during tetanization, adenosine (50 microM) significantly suppressed mos...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91061-5
更新日期:1991-03-08 00:00:00
abstract::Although much is known regarding the modulation of ion channels through protein phosphorylation, little is known about their dephosphorylation by protein phosphatases (PrPs). To address this issue we examined the effects of a phosphatase inhibitor, okadaic acid (OA), and protein phosphatases obtained from rabbit skele...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90611-x
更新日期:1991-05-17 00:00:00
abstract::The activities of 5'-nucleotidase (EC 3.1.3.5) and of 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) (EC 3.1.4.37) were measured in crude membrane preparations from 6 brain regions of hypothyroid rats 31 days and 42 days after conception (8-9 days and 19-20 days after birth respectively) and from normal rats 31, 36...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90185-2
更新日期:1983-04-01 00:00:00
abstract::Vanadate (VO-3), an essential trace element with insulin-mimetic actions, produces systemic hyperglycemia following central administration in mice. The hyperglycemic effect is due to specific action of vanadate or its reduced form, vanadyl (VO2+); other ions of similar atomic weight (Cr, Mn) or structure (phosphate) h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90615-9
更新日期:1987-09-01 00:00:00
abstract::Perineal muscles essential for copulatory functioning are innervated by Onuf's nucleus in humans and the spinal nucleus of the bulbocavernosus (SNB) and dorsolateral nucleus (DLN) in rats. These structures sexually differentiate as a result of developmental androgen exposure in most species examined. The homologous st...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.05.056
更新日期:2010-07-30 00:00:00
abstract::Cortical stimulation has been demonstrated to alleviate certain pain conditions. The aim of this study was to determine the responses of the spinal cord dorsal horn neurons to stimulation of the primary somatosensory cortex (SSC). We hypothesized that direct stimulation of the SSC will inhibit the activity of spinal d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.07.044
更新日期:2005-09-28 00:00:00
abstract::Retinal ganglion cells were labeled with horseradish peroxidase injected into the superior colliculus of normal pigmented rats. It is shown that virtually all ganglion cells with crossed axons project to the tectum, thus including all cell types described so far in the rat. The results contrast with the conclusion tha...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90371-2
更新日期:1983-08-01 00:00:00
abstract::Acute bouts of exercise have been shown to produce transient increases in regional cerebral glucose utilization, oxygen uptake, and cerebral blood flow in motor cortex, striatum, and hippocampus. The purpose of this study was to determine whether or not chronic exercise will cause long-term metabolic plasticity in bra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03200-5
更新日期:2001-02-09 00:00:00
abstract::In the present study, we report the localization of the Rev-ErbA alpha and beta nuclear orphan receptors, two closely related members of the nuclear hormone receptor superfamily, in the brain. Both Rev-ErbA variant mRNAs were highly expressed in the olfactory bulb, the hippocampus, and in the granular cells of the cer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00507-0
更新日期:1996-12-16 00:00:00
abstract::The immunohistochemical distributions of tyrosine hydroxylase (TH), calmodulin (CaM) and calcium/CaM-dependent protein kinase II (CaMKII) in the rat forebrain were compared quantitatively to confirm our previous finding that TH activity and dopamine synthesis in the brain are regulated by a calcium/CaM-dependent syste...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02271-0
更新日期:2002-04-12 00:00:00
abstract::The ontogenesis of chromogranins A and B and catecholamines was investigated for rat adrenal medulla. The chromogranins, the major secretory peptides of chromaffin granules, were characterized by one- and two-dimensional immunoblotting. Chromogranin B appeared identical in fetal and postnatal adrenals. On the other ha...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91475-3
更新日期:1989-01-23 00:00:00
abstract::The postnatal development of retinogeniculate, retinopretectal and retinotectal projections has been studied by the anterograde transport of proline-labeled proteins in 20 pouch young opossums aged from 10 to 60 days. Radioautographical findings suggest delayed development of uncrossed as compared to crossed projectio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90971-x
更新日期:1978-05-12 00:00:00
abstract::Bilateral removal of the cortical visual area in newborn cats produces degeneration of retinal ganglion cells. Measurements of over 4,000 cells and calculation of neuron densities from sample areas of retina in the adult show that the medium sized cell population in peripheral retina is reduced by 68%, whereas the pop...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90480-7
更新日期:1981-05-18 00:00:00