Acute enhancement of spinal cord synaptosomal (Na+ + K+)-ATPase activity in cats following intravenous methylprednisolone.

Abstract:

:The acute intravenous administration of high doses of methylprednisolone sodium succinate (15-90 mg/kg) to cats enhanced (Na+ + K+)-ATPase activity as much as 2-fold in synaptosomes prepared from lumbar spinal cord removed following drug administration. The effect was apparent within 5 min and was statistically significant at 1 h following a single injection of methylprednisolone 90 mg/kg. (Na+ + K+)-ATPase activity had returned to control levels by 24 h post-injection. The implication of these findings to the treatment of spinal cord trauma and the reported neurophysiological effects of glucocorticoids are discussed.

journal_name

Brain Res

journal_title

Brain research

authors

Braughler JM,Hall ED

doi

10.1016/0006-8993(81)90311-5

subject

Has Abstract

pub_date

1981-08-31 00:00:00

pages

464-9

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(81)90311-5

journal_volume

219

pub_type

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