Abstract:
:The acute intravenous administration of high doses of methylprednisolone sodium succinate (15-90 mg/kg) to cats enhanced (Na+ + K+)-ATPase activity as much as 2-fold in synaptosomes prepared from lumbar spinal cord removed following drug administration. The effect was apparent within 5 min and was statistically significant at 1 h following a single injection of methylprednisolone 90 mg/kg. (Na+ + K+)-ATPase activity had returned to control levels by 24 h post-injection. The implication of these findings to the treatment of spinal cord trauma and the reported neurophysiological effects of glucocorticoids are discussed.
journal_name
Brain Resjournal_title
Brain researchauthors
Braughler JM,Hall EDdoi
10.1016/0006-8993(81)90311-5subject
Has Abstractpub_date
1981-08-31 00:00:00pages
464-9issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(81)90311-5journal_volume
219pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Opioid peptides and their receptors have been localized to the inner ear of the rat and guinea pig mammalian models. The expression of mu opioid receptor (MOR) in the human and mouse cochlea is not yet known. We present MOR protein localization by immunohistochemistry and mRNA expression by in situ hybridization in th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.09.051
更新日期:2014-11-24 00:00:00
abstract::ATP has been recognized as an important extracellular signaling molecule and P2X receptors are membrane ion channels activated by the binding of extracellular ATP. Since both AQP4 and P2X7 receptor (P2X7R) are known to be present in astrocytes, we examined whether P2X7R activation plays a role in the regulation of AQP...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.12.023
更新日期:2008-02-21 00:00:00
abstract::We previously described a rat model where the injection of formalin in the tail induced a facilitation of the hindpaw withdrawal reflexes (hyperalgesia). In the present work, after injecting formalin in the tail, we measured the levels of pro-nociceptive mediators tumor necrosis factor-alpha (TNF) and substance P (SP)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.06.007
更新日期:2004-09-03 00:00:00
abstract::An expanding body of data has indicated that the seizure prone state in genetically epilepsy-prone rats (GEPRs) is partially caused by deficits in central nervous system noradrenergic transmission. Several lines of evidence suggest that the noradrenergic terminals in the superior colliculus (SC) may act as determinant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01139-6
更新日期:1998-01-12 00:00:00
abstract::The entire set of giant interneurons (GIs) in the nerve cord of the cockroach, Periplaneta americana, was ablated using either electrolytic or surgical techniques. All animals with these lesions were capable of turning and running away from standard wind puffs. However, all animals responded much less frequently to st...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91202-4
更新日期:1988-04-05 00:00:00
abstract::Exercise has been shown to influence learning and memory. Most studies were performed with a voluntary running paradigm (e.g. running wheel) in mice. However, such effects of exercise on learning and memory are less well demonstrated using a forced running paradigm (e.g. treadmill). The present study was designed to e...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.07.023
更新日期:2006-10-03 00:00:00
abstract::The functional influence of the cholinergic input to cat dLGN has been examined by assessing the action of iontophoretically applied acetylcholine (ACh) on the visual responses of cells in layers A and A1. Iontophoretically applied pulses of ACh exerted a strong excitatory action on all 113 cells studied within these ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90059-8
更新日期:1983-12-05 00:00:00
abstract::DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane] is a potent neurotoxicant in both vertebrate and invertebrate species. We have previously reported that neonatal exposure to DDT affects the muscarinic cholinergic receptors (MAChR) in the cerebral cortex in the neonatal mouse, leading to permanent disturbances in th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90144-x
更新日期:1992-06-12 00:00:00
abstract::The effects of glucagon like peptide-1 (GLP-1) on reflex swallowing were examined using anaesthetized rats. GLP-1 was injected into the dorsal vagal complex (DVC) using glass micropipettes. Swallowing was induced by repeated electrical stimulation of the central cut end of the superior laryngeal nerve (SLN) and was id...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.07.004
更新日期:2017-09-15 00:00:00
abstract::We tested the hypothesis that intravenous infusion of human marrow stromal cells (hMSC) with a nitric oxide donor, (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl) aminio] diazen-1-ium-1,2-diolate (DETA/NONOate), enhances angiogenesis, neurogenesis and neurological functional recovery after stroke in rats compared to indivi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.11.080
更新日期:2004-04-16 00:00:00
abstract::Previous studies focusing on the relationship between lateralization of language function and age suffer from lack of a balanced distribution of age and handedness among participants, especially in the extremes of age. This limits our understanding of the influence of these factors on lateralization of language circui...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.08.021
更新日期:2017-11-01 00:00:00
abstract::Rat central nervous system (CNS) tissue sections were immunostained by the peroxidase-anti-peroxidase (PAP) method using a rabbit serum directed against rat liver 5'-nucleotidase. In paraffin sections from the brains of 60-day-old rats 5'-nucleotidase immunoreactivity occurred in the same white-matter regions as myeli...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90090-2
更新日期:1985-05-01 00:00:00
abstract::Molecular mechanism underlying ischemic stroke remains poorly understood. We previously reported glucose 6-phosphate dehydrogenase (G6PD) activity in pentose phosphate pathway (PPP) is activated via heat shock protein 27 (HSP27) phosphorylation at serine 85 (S85) by ataxia telangiectasia mutated (ATM) kinase during ce...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.03.001
更新日期:2018-05-15 00:00:00
abstract::We investigated the effect of beta-estradiol (E2) on synaptogenesis in the hippocampus using organotypic hippocampal slice cultures and subregional hippocampal neuron cultures. E2 increased the expression of PSD95, a postsynaptic marker, specifically in stratum lucidum of Cornu Ammonis 3 (CA3SL) in cultured hippocampa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.02.093
更新日期:2007-05-30 00:00:00
abstract::Following single injections of horseradish peroxidase (HRP) in the superior colliculus (SC) and [3H]proline in the striate cortex of rats, a close correspondence was observed in the topographical arrangements of extrastriate cortical fields of HRP retrograde label and of isotope anterograde label. These results suppor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90318-3
更新日期:1982-06-24 00:00:00
abstract::Alpha-synuclein is a natively unfolded protein playing a key role in the regulation of several neuronal synaptic functions in physiological and pathological conditions. Many studies, over the past years, have shown that it is actively involved in PD pathophysiology. Alpha-synuclein is integrated in a complex network o...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2012.04.014
更新日期:2012-10-02 00:00:00
abstract::The retrorubral field (RRF) contains numerous dopaminergic neurons and projects to the parvicellular reticular formation (RFp) of the medullary and pontomedullary brainstem, where many premotor neurons project to the orofacial motor nuclei. To know how the amygdala affects the RRF-RFp pathway in the rat, we first exam...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.09.118
更新日期:2010-01-08 00:00:00
abstract::We have previously demonstrated an absence of ovarian steroid negative feedback on pulsatile luteinizing hormone (LH) release between estrus and early diestrus 1 (D1) in the rat estrous cycle. The object of the present study was to determine if there was a steroid-independent endogenous opioid peptide (EOP) suppressio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90902-4
更新日期:1987-07-28 00:00:00
abstract::Immobilization of frogs for 1 h induces analgesia which is blocked but not reversed by low doses of naloxone. After 9 days of daily immobilization for 1 h, the treatment fails to cause analgesia thus indicating that tolerance has developed. Animals tolerant to immobilization-induced analgesia do not show cross-toleran...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90073-8
更新日期:1984-04-02 00:00:00
abstract::Extracellular field recordings were made in CA1 in the hippocampal explant cultures in oxygenated artificial cerebrospinal fluid. Schaffer collaterals were stimulated with 1-s trains of 60 Hz pulses every 10 min. Seizures were reliably elicited with progressive lengthening over 1-2 h. D-APV, an N-methyl-D-aspartate (N...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91171-a
更新日期:1992-08-28 00:00:00
abstract::The effect of immunoneutralization of hypothalamic neuropeptide Y (NPY) on food intake was examined to clarify the involvement of NPY in the control mechanism of feeding behavior. Injection of anti-NPY gamma-globulin into the bilateral hypothalamic paraventricular nuclei of 24-h food-deprived rats significantly inhibi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91727-a
更新日期:1993-01-22 00:00:00
abstract::The ontogeny of adenosine receptors was studied in rat brain and spinal cord using the specific ligand [3H]cyclohexyladenosine [( 3H]CHA). The [3H]CHA affinity constant (Kd) and the maximum receptor binding capacity (Bmax) were analyzed at all ages and in all CNS regions studied. Throughout development the Kd of [3H]C...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90080-4
更新日期:1984-03-01 00:00:00
abstract::IgLONs are a family of four GPI-anchored cell adhesion molecules that regulate neurite outgrowth, synaptogenesis and may act as tumour suppressor genes. IgLONs are thought to function as monomers or homodimers and we have proposed that IgLONs also act as heterodimeric complexes termed Dimeric IgLONs or DIgLONs. Here w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.12.028
更新日期:2011-02-16 00:00:00
abstract::The effects of the epileptogenic agent pentylenetetrazole (PTZ) on membrane currents of native oocytes of Xenopus laevis were studied. PTZ elicits a response that consists of two inward currents. The first one is interpreted to be due to a decrease of potassium permeability since: (1) the input resistance is increased...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90225-k
更新日期:1991-07-05 00:00:00
abstract::The expression of the calcium-binding protein calretinin (CR) in the chick cochlear nucleus, nucleus magnocellularis (NM), was examined after unilateral cochlea removal in hatchlings and 3-week-old birds. Following survival times of 3, 6 or 12 h or 1, 3 or 7 days, CR mRNA was localized by in situ hybridization using a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02476-8
更新日期:2000-08-04 00:00:00
abstract::Neurons (n = 107) were recorded, in anaesthetized rats, with extracellular micropipettes, in the nucleus centralis of the amygdala (Ce). The activity of a large majority (77%) was exclusively or preferentially affected by noxious stimuli applied in any area of the body. The rest of the neurons was not activated by any...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91512-f
更新日期:1990-07-23 00:00:00
abstract::Honokiol, a major bioactive constituent of the bark of Magnolia officinalis has been confirmed to have the neuroprotective effect on ischemic stroke in rats. This study was designed to observe the therapeutic time window of honokiol microemulsion on cerebral ischemia-reperfusion injury to support its potential for fut...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.11.004
更新日期:2013-01-23 00:00:00
abstract::Converging evidence implicates alterations in multiple signaling pathways in the etiology of schizophrenia. Previously, these studies were limited to the analysis of one or a few phosphoproteins at a time. Here, we use a novel kinase array platform to simultaneously investigate the convergence of multiple signaling ca...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.04.029
更新日期:2014-06-03 00:00:00
abstract::The present study was undertaken to examine the differential effect of estrogen (E) on the expression of tyrosine hydroxylase (TH) in the substantia nigra compacta (SNc) and in two subdivisions of the ventral tegmental area in ovariectomized (ovx) and ovx plus estradiol benzoate (ovx+E)-treated female rats. Cell count...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02323-4
更新日期:2000-06-23 00:00:00
abstract::Intracellular recordings and labelings with horseradish peroxidase (HRP) of expiratory (E) neurons were performed in decerebrate, paralyzed, and ventilated rats. A total of 37 neurons were recorded, from which 4 cells and 1 axon were labeled. They were located in two regions of the ventrolateral medulla. One was in th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90687-5
更新日期:1992-04-03 00:00:00