Injection of anti-neuropeptide Y gamma-globulin into the hypothalamic paraventricular nucleus decreases food intake in rats.

abstract：:alpha-Tocopherol (alpha-TC) is considered an important endogenous brain antioxidant. The utility of brain alpha-TC levels as an index of in vivo lipid peroxidation has recently been suggested. Therefore, we explored the significance of alpha-TC levels in brains to ischemic insults associated with global or focal cereb...

journal_title：Brain research

authors： Yue TL,Barone FC,Gu JL,Feuerstein GZ

更新日期：1993-04-30 00:00:00

abstract：:Locations of cells responsive to microiontophoretically applied angiotensin II (AII) were compared to distributions of AII receptor binding sites identified by autoradiography in the lumbar enlargement region of the rat spinal cord. Angiotensin II receptor binding sites were densely concentrated in the superficial lay...

journal_title：Brain research

authors： White SR,Penner JD,Speth RC,Chan JY

更新日期：1988-02-16 00:00:00

abstract：:L-Tryptophan produces a significant antihypertensive effect in spontaneously hypertensive rats while D-tryptophan does not change blood pressure. Both isomers of tryptophan significantly increase brain serotonin to the same extent at a time when the antihypertensive effect of L-tryptophan is maximal. Thus, the antihyp...

journal_title：Brain research

authors： Wolf WA,Kuhn DM

更新日期：1984-03-19 00:00:00

abstract：:Many AIDS patients suffer from cognitive impairments including deficits in learning and memory. The Human Immunodeficiency Virus-1 (HIV-1) envelope glycoprotein gp120 is one possible mediator of these impairments. This is because gp120 activates brain microglial cells and astrocytes, and in vivo activation of glia lea...

journal_title：Brain research

authors： Pugh CR,Johnson JD,Martin D,Rudy JW,Maier SF,Watkins LR

更新日期：2000-04-07 00:00:00

abstract：:The ontogenic development of neurophysin has not been investigated so far. To study this problem, electron microscopic immunohistochemistry was performed on ultrathin sections of the posterior pituitary of foetal and newborn rats. A concomitant appearance of secretory granules and neurophysin was first noted in the po...

journal_title：Brain research

authors： Leclerc R,Pelletier G

更新日期：1977-07-01 00:00:00

abstract：:Neonatal destruction of nigrostriatal dopamine neurons by cerebroventricular injection of 6-hydroxydopamine (6-OHDA) results in a serotonin (5-HT) hyperinnervation of the rostral neostriatum in adult rat. Quantitative ligand-binding autoradiography was used to compare the density of various 5-HT receptor subtypes in t...

journal_title：Brain research

authors： Radja F,Descarries L,Dewar KM,Reader TA

更新日期：1993-03-26 00:00:00

abstract：:Ischemic stroke is caused by the interruption of cerebral blood flow that leads to brain damage with long-term sensorimotor deficits. Stem cell transplantation may recover functional deficit by replacing damaged brain. In this study, we attempted to test whether the human neural stem cells (NSCs) can improve the outco...

journal_title：Brain research

authors： Chu K,Kim M,Park KI,Jeong SW,Park HK,Jung KH,Lee ST,Kang L,Lee K,Park DK,Kim SU,Roh JK

更新日期：2004-08-06 00:00:00

abstract：:Quantitative morphological techniques have revealed several new aspects of the action of the Staggerer mutant gene. Staggerer is an autosomal recessive gene which causes ataxia and severe malformation of the cerebellar cortex in mice. The Purkinje cells of the cerebellar cortex are small, abnormal in morphology and re...

journal_title：Brain research

authors： Roffler-Tarlov S,Herrup K

更新日期：1981-06-29 00:00:00

abstract：:This ERP study explores the brain's response to the manipulation of motor compatibility in action-related language. In Experiment 1 participants read sentences in which a protagonist performed two different manual actions either simultaneously or consecutively (e.g. While/after cleaning the wound he unrolled the banda...

journal_title：Brain research

authors： Santana EJ,de Vega M

更新日期：2013-08-14 00:00:00

abstract：:The A-ring reduced metabolite of deoxycorticosterone, 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone (THDOC) was recently shown to act at the gamma-aminobutyric acid receptor-chloride ion channel complex in rat brain. The behavioral profile of THDOC was investigated using two animal models of anxiety, the two-chambere...

journal_title：Brain research

authors： Crawley JN,Glowa JR,Majewska MD,Paul SM

更新日期：1986-11-29 00:00:00

abstract：:This study shows that in the choroid plexus of Rana esculenta particulate guanylate cyclase (GC) is appreciably stimulated by porcine brain natriuretic peptide (BNP). Ultracytochemical tests for GC show that BNP notably increases the enzymatic reaction product along the apical surfaces of the epithelial cells. It can ...

journal_title：Brain research

authors： Vagnetti D,Tei S,Secca T,Santarella B,Roscani C,Farnesi RM

更新日期：1995-12-24 00:00:00

abstract：:Neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by progressive loss of cognitive function, dementia, and problems with movements. In order to find new protein biomarkers of high specificity from cerebrospinal fluid (CSF) of AD and PD patients, one-dimensiona...

journal_title：Brain research

authors： Yin GN,Lee HW,Cho JY,Suk K

更新日期：2009-04-10 00:00:00

abstract：:Autoradiographic techniques were used to test if positive modulators of AMPA-type glutamate receptors have regionally differentiated effects on ligand binding. Cyclothiazide, a drug with ten fold greater effects on 'flip' than 'flop' splice variants of the receptors, had unequal effects across the subdivisions of hipp...

journal_title：Brain research

authors： Kessler M,Mutneja MS,Rogers G,Lynch G

更新日期：1998-02-02 00:00:00

abstract：:In an autopsy study on 29 male Aborigines and 57 male Caucasians, macroscopic and microscopic parameters of postnatal cerebellar development were determined and described by mathematic growth functions. For the whole cerebellum and its cortical layers volume measurements revealed delayed maturation for Aborigines comp...

journal_title：Brain research

authors： Riedel A,Klekamp J,Harper C,Kretschmann HJ

更新日期：1989-10-16 00:00:00

abstract：:Few clinical or experimental studies have carried out systematic investigations of cutaneous and deep sensibility in areas with referred muscle pain. Therefore, no clear signs of increased or decreased psychophysical responses to various somatosensory stimuli are found in referred pain areas. In the present study, a t...

journal_title：Brain research

authors： Graven-Nielsen T,Arendt-Nielsen L,Svensson P,Jensen TS

更新日期：1997-01-02 00:00:00

abstract：:The volume of nucleus HVc of the avian song system varies greatly both among and within songbird species, and is positively correlated to song complexity in many species. Moreover, the number of neurons in HVc predicts the ability of individual zebra finches to imitate song accurately. To better understand this brain/...

journal_title：Brain research

authors： Ward BC,Nordeen EJ,Nordeen KW

更新日期：2001-06-22 00:00:00

abstract：:The duration of the sensitive period of the kitten visual cortex to the effects of monocular deprivation was explored by studies of the behavioral and physiological recovery from extended periods of monocular occlusion imposed from birth, and by examination of the physiological effects of a 3 month period of monocular...

journal_title：Brain research

authors： Cynader M,Timney BN,Mitchell DE

更新日期：1980-06-09 00:00:00

abstract：:Tyrosine hydroxylase phenotype expression was investigated in the catecholaminergic population of the locus coeruleus neurons of two pure inbred mouse strains, Balb/C and C57Black/6. Therefore, we have characterized the precise organization of tyrosine hydroxylase-expressing perikarya population, in control animals an...

journal_title：Brain research

authors： Ginovart N,Marcel D,Bezin L,Garcia C,Gagne C,Pujol JF,Weissmann D

更新日期：1996-05-20 00:00:00

abstract：:The aim of this work was to investigate the modulation of the cardiovascular effects of neuropeptide Y (NPY) in the nucleus tractus solitarii (NTS) by angiotensin II (Ang II) and to determine the NPY receptor subtype involved in this modulation. Anesthesized Sprague-Dawley rats received microinjections in the NTS of A...

journal_title：Brain research

authors： Díaz-Cabiale Z,Fuxe K,Coveñas R,González-Barón S,Narváez JA

更新日期：2003-09-05 00:00:00

abstract：:Abnormal increase in native long-chain ceramides (lcCer) in AD implicates roles in neuronal atrophy and cognitive dysfunction especially in view of divergent roles this second messenger plays in cell function. Since clearance is mediated by glucosylceramide synthase (GCS, EC 2.4.1.80) levels of the enzyme were compare...

journal_title：Brain research

authors： Marks N,Berg MJ,Saito M,Saito M

更新日期：2008-01-29 00:00:00

abstract：:The possibility that central adenosine A1 and A2a receptors mediate opiate dependence was examined in morphine-treated mice using radioligand binding methods. Mice treated with morphine for 72 h demonstrated significant increases in naloxone precipitated abstinence behaviors of jumping, wet-dog shakes, teeth chatterin...

journal_title：Brain research

authors： Kaplan GB,Leite-Morris KA,Sears MT

更新日期：1994-09-19 00:00:00

abstract：INTRODUCTION:Ischemic postconditioning (IpostC) has been described in both heart and brain. The first aim of this study was to evaluate the effects of IpostC on brain infarct size and neurological function in the middle cerebral artery occlusion (MCAO) model. The second aim was to determine the involvement of the mitoc...

journal_title：Brain research

authors： Robin E,Simerabet M,Hassoun SM,Adamczyk S,Tavernier B,Vallet B,Bordet R,Lebuffe G

更新日期：2011-02-23 00:00:00

abstract：:In rats under urethane or pentobarbitone anesthesia, Ca2+ -sensitive microelectrodes were inserted into CA3 and CA1 hippocampal cells. In 23 neurons with a mean resting membrane potential (Vm) of -56.9 mV, the Ca potential (VCa) fell below Vm by an average of -22.1 mV (S.D. +/- 19.1 mV), indicating a mean intracellula...

journal_title：Brain research

authors： Krnjević K,Morris ME,Ropert N

更新日期：1986-05-21 00:00:00

abstract：:Zinc and other cations were iontophoretically applied to neurones in the frontoparietal cortex of urethane-anaesthetised rats and their effect on the activity of these cells was examined. Slow and often prolonged increases in firing rate occurred in 45.2% of neurones after zinc application and 72.7% after barium. Calc...

journal_title：Brain research

authors： Wright DM

更新日期：1984-10-08 00:00:00

abstract：:To examine whether the activation of brainstem neurons during ingestion is due to orosensory afferents or post-ingestive factors, neuronal activation in response to intraoral and intragastric infusions of taste stimuli was compared in the area postrema (AP), nucleus tractus solitarius (NTS) and parabrachial nucleus (P...

journal_title：Brain research

authors： Yamamoto T,Sawa K

更新日期：2000-06-02 00:00:00

abstract：:The intracellular pH, 7.54 +/- 0.03 (mean +/- S.D., n = 15), determined with the Neutral red method, of the hippocampal brain slice preparation under baseline incubation conditions is considerably more alkaline than the bath buffer pH. Neutralization by amiloride suggests that the alkalinity was due to Na+/H+ exchange...

journal_title：Brain research

authors： Lin CW,Kalaria RN,Kroon SN,Bae JY,Sayre LM,LaManna JC

更新日期：1996-08-26 00:00:00

abstract：:Whilst the brain-specific benzodiazepine receptor has been assumed to show a late evolutionary appearance, we present evidence for the presence of a central benzodiazepine binding site in sharks, which shows a high affinity for [3H]Ro 15-1788. However, the receptor density and the affinities of several benzodiazepine ...

journal_title：Brain research

authors： Hebebrand J,Friedl W,Reichelt R,Schmitz E,Möller P,Propping P

更新日期：1988-04-19 00:00:00

abstract：:The purpose of the present investigation was to record electrophysiological responses from single fibers in the hamster superior laryngeal nerve (SLN) that were responsive to chemical stimulation of the larynx. Twenty chemical solutions, commonly used in studies of mammalian gustatory physiology, were applied to taste...

journal_title：Brain research

authors： Dickman JD,Smith DV

更新日期：1988-05-31 00:00:00

abstract：:Pregabalin is useful for treating neuropathic pain, but known to increase body weight as a side effect. To investigate the mechanism of this increase in body weight, we focused on dopamine in the lateral hypothalamus (LH) and examined the effects of pregabalin on dopamine levels in the LH and food intake. The dopamine...

journal_title：Brain research

authors： Ikeda H,Yonemochi N,Ardianto C,Yang L,Kamei J

更新日期：2018-12-15 00:00:00

abstract：:Accumulating evidence indicates that extensive microglia activation-mediated local inflammation contributes to neuronal injury in cerebral ischemia. We have previously shown that 4-(2-butyl-6, 7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid (DCPIB), a potent volume-regulated anion channel (VRAC) inhibitor, s...

journal_title：Brain research

authors： Han Q,Liu S,Li Z,Hu F,Zhang Q,Zhou M,Chen J,Lei T,Zhang H

更新日期：2014-01-13 00:00:00