Abstract：
:Opioid peptides and their receptors have been localized to the inner ear of the rat and guinea pig mammalian models. The expression of mu opioid receptor (MOR) in the human and mouse cochlea is not yet known. We present MOR protein localization by immunohistochemistry and mRNA expression by in situ hybridization in the human and mouse spiral ganglia (SG) and organ of Corti. In the human most of the (SG) neurons were immunoreactive; a subset was non-immunoreactive. In situ hybridization revealed a similar labeling pattern across the neurons of the SG. A similar distribution MOR pattern was demonstrated in the mouse SG. In the mouse organ of Corti MOR was expressed in inner and outer hair cells. Fibers underneath the inner hair cells were also MOR immunoreactive. These results are consistent with a role of MOR in neuromodulation of the auditory periphery. The present results show that the expression of MORs is well-conserved across multiple mammalian species, indicative of an important role in auditory processing.
journal_name
Brain Resjournal_title
Brain researchauthors
Nguyen KD,Mowlds D,Lopez IA,Hosokawa S,Ishiyama A,Ishiyama Gdoi
10.1016/j.brainres.2014.09.051subject
Has Abstractpub_date
2014-11-24 00:00:00pages
10-9eissn
0006-8993issn
1872-6240pii
S0006-8993(14)01300-6journal_volume
1590pub_type
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