Abstract：
:To characterize optical responses (ORs) evoked by white matter (WM) stimulation in slices of rat visual cortex (VC) stained with voltage sensitive dyes, time course of ORs in each layer was investigated by recording ORs with a linearly aligned photodiode array, and the spatial patterns of the ORs at specified time after stimulation were investigated by a CCD camera in combination with stroboscopic illumination. The ORs recorded by the photodiode array were an increase in absorption at 700 nm and a decrease in the wavelength below 650 nm, suggesting that the ORs were dye related. The ORs were compared with field potentials (FPs) to clarify that neural events were represented by the ORs, and in support of this view, we found that the first order spatial differentials of ORs and that of FPs were in good agreement. We further compared ORs with intracellular responses, and found that the ORs mainly represent postsynaptic potentials (PSPs) of VC neurons except for the deeper part of layer VI, where a component representing action potentials in fibers stimulated directly was observed. The time-lapse imaging of ORs showed that excitation first propagated vertically up to layer I and subsequently in the horizontal direction along layers II-III and V-VI as in previous investigations. Spatio-temporal patterns of ORs under blockade of synaptic transmission were also investigated to reveal activity of fibers evoked by WM stimulation which produced such patterns of propagation.
journal_name
Brain Resjournal_title
Brain researchauthors
Tanifuji M,Yamanaka A,Sunaba R,Terakawa S,Toyama Kdoi
10.1016/0006-8993(96)00767-6subject
Has Abstractpub_date
1996-10-28 00:00:00pages
83-95issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(96)00767-6journal_volume
738pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:alpha-Tocopherol (alpha-TC) is considered an important endogenous brain antioxidant. The utility of brain alpha-TC levels as an index of in vivo lipid peroxidation has recently been suggested. Therefore, we explored the significance of alpha-TC levels in brains to ischemic insults associated with global or focal cereb...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91215-e
更新日期：1993-04-30 00:00:00
abstract：:The two major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA), alpha-methyldopamine (alpha-MeDA) and 3-O-methyl-alpha-methyldopamine (3-O-Me-alpha-MeDA), were administered to rats intracerebroventricularly and into brain parenchyma. In addition, their precursors, (alpha-MeDOPA and 3-O-Me-alpha-MeDOPA, respecti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91297-e
更新日期：1991-04-05 00:00:00
abstract：:Acidification of the incubation medium markedly increased lipid peroxidation of cortical brain slices. Lactic acidosis caused a more extensive lipid peroxidation than did phosphoric acidosis (+35% at pH 6 and +81% at pH 5), probably due to the rapid diffusion of the protonated form of lactic acid across cell membranes...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90703-x
更新日期：1991-01-18 00:00:00
abstract：:The objective of the study was to investigate creativity in relation to brain function by assessing creative thinking in various neurological populations. Several measures were employed to assess different facets of creative thinking in clinical groups with frontal lobe, basal ganglia or parietal-temporal lesions rela...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.09.007
更新日期：2012-10-30 00:00:00
abstract：:The rostral projection of A delta and C primary afferents in Lissauer's tract (LT) was studied by assessing how far, rostrally, axons entering at a given level could be activated by electrical stimulation. Sural A delta primary afferents in LT exhibited a rostral projection at least as far as the L3/L4 border, 4 segme...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90617-7
更新日期：1986-12-03 00:00:00
abstract：:Cell number and proliferation of reactive astrocytes were studied quantitatively in the stabbed cerebral cortex of adult mice, using immunohistochemistry for glial fibrillary acidic protein (GFAP) and [3H]thymidine autoradiography. GFAP-positive astrocytes increased in cell number gradually from 24 to 96 h after stabb...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90757-3
更新日期：1988-06-07 00:00:00
abstract：:Intracerebroventricular (i.c.v.) infusion of sodium in rats increases cerebrospinal fluid (CSF) [Na], mimicking the effects of a high salt diet in salt-sensitive strains and causing sympathetic hyperactivity and a pressor response that are mediated via both an endogenous brain ouabainlike substance (OLS) and the brain...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.06.056
更新日期：2004-09-24 00:00:00
abstract：:This study explores the longitudinal assessment of visual evoked potentials (VEPs) in the rabbit as a method for defining factors underlying functional and structural changes associated with optic neuritis and the inflammatory demyelinating diseases. In rabbits with experimental autoimmune encephalomyelitis (EAE) indu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90557-4
更新日期：1988-10-18 00:00:00
abstract：:The role of the lateral parabrachial area (lPB) in the acquisition of a delayed taste aversion learning task (TAL) was examined by delivering the peripherally acting aversive compound, methylscopolamine (MSP), through two different routes, intraperitoneal and intraventricular. Consistent with previous anatomical, beha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02453-7
更新日期：2000-07-14 00:00:00
abstract：:The time-course of intracellular glutathione (GSH) values after incubation with L-buthionine-(S,R)-sulfoximine (BSO), a selective inhibitor of gamma-glutamylcysteine synthetase, showed that glutathione turns over with a half-life of 5 h. Intracellular GSH was assayed by flow cytometry using three different methods. As...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91264-s
更新日期：1993-08-06 00:00:00
abstract：:The current study assessed the influence of excitotoxic lesions of the insular cortex (IC) on taste-potentiated odor aversion (TPOA) learning. Water-deprived rats initially received a single odor-toxicosis or odor/taste-toxicosis pairing and were subsequently tested, in separate trials, with the odor and the taste sti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.051
更新日期：2009-11-10 00:00:00
abstract：:The DNA content and activity of acid and alkaline deoxyribonucleases (DNases) were measured through age 60 days in the hypothalamus of female rats injected s.c. with 1.25 mg testosterone propionate 48 h after birth. DNA significantly increases through age 60 days, however, androgenization does not affect the DNases or...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90273-1
更新日期：1985-02-01 00:00:00
abstract：:Hippocampal cholinergic neurons are sensitive to acute ethanol administration, and specific alterations are seen in the functioning of these neurons following chronic ethanol. The present study examined the effects of chronic ethanol exposure and withdrawal on the sensitivity of the hippocampus to local injection of p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90500-1
更新日期：1985-06-03 00:00:00
abstract：:The localization of serotonergic, various peptidergic and possibly cholinergic neurons in the medullary raphe nuclei that project to the lumbosacral spinal cord have been studied using a retrograde transport method combined with immunocytochemical and histochemical techniques. Spinally projecting neurons stained for s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90079-3
更新日期：1983-12-12 00:00:00
abstract：:The particular vulnerability of hippocampal CA3/CA4 neurons to intracerebroventricularly administered kainate did not occur in rats until postnatal day 16. Glutamate applied in the same way failed to show comparable neurodegenerative signs, even when administered in large doses to adult animals. Alternatively, both ka...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90004-x
更新日期：1984-05-01 00:00:00
abstract：:This manuscript describes the use of staining of Fos-related antigens (FRAs) as markers for changes in neuronal activity. The model system consisted of the tuberoinfundibular dopamine (TIDA) neurons located in the arcuate nucleus of the hypothalamus. Under normal conditions, these neurons are devoid of c-Fos staining ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90481-2
更新日期：1994-08-22 00:00:00
abstract：:Angiotensin peptides are thought to act as neurotransmitters or neuromodulators in central osmoregulation. We tested the hypothesis that angiotensin peptides are released in the paraventricular nucleus (PVN) of the hypothalamus upon local osmotic stimulation. Brain microdialysis and radioimmunoassay (RIA) techniques w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91215-7
更新日期：1994-02-21 00:00:00
abstract：:Radioautography was used to study the intraneuronal distribution of [3H]-serotonin (5-HT) and/or its derivatives selectively taken up by the olfactory bulb (OB) serotonergic terminals and subsequently transported to their parent cell bodies in the midbrain raphe nuclei. This was done 24 h after injection of [3H]5-HT i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90405-9
更新日期：1980-09-08 00:00:00
abstract：:Rats treated neonatally with pargyline and 5,7-dihydroxytryptamine (5,7-DHT) have an elevated paCO2 and reduced minute ventilation when given 0.7% halothane in oxygen as adults. Serotonin content in the spinal cord of 5,7-DHT treated rats was undetectable and TRH content was reduced by 35%. The 5,7-DHT treated rats we...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91440-9
更新日期：1984-04-30 00:00:00
abstract：:Repetitive generation of spreading depression (SD) waves may induce metabolic and functional disturbances in the invaded brain regions. In order to better characterize this state, up to 60 SD waves were elicited in the cerebral cortex of anesthetized rats by intracortical injections of 2 microliters of isotonic K-acet...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91399-0
更新日期：1987-02-24 00:00:00
abstract：:The activity of single dopaminergic (DA) neurons (total n = 77) in the midbrain of awake, unrestrained rats was examined. The firing rates and patterns of ventral tegmental area (A10) cells (n = 39) were similar to those of identified DA neurons in anesthetized and paralyzed rats. Unit activity was briefly stimulated ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90988-7
更新日期：1987-03-03 00:00:00
abstract：:The present study has shown that after intravenous injection of [125I]NGF the time-course of appearance of radioactivity in all organs studied with the exception of sympathetic and sensory ganglia, roughly paralleled that of the blood. The highest levels were reached immediately after injection, after which the radioa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90530-8
更新日期：1976-06-11 00:00:00
abstract：:Using a dual-serial-arithmetic paradigm, we examined whether a capacity limitation constrains the neural activation that underlies dual-task performance. Six conditions were run in the experiment (the baseline, single-addition, single-subtraction, dual-addition, dual-subtraction, and the dual-operation condition). In ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.12.070
更新日期：2008-03-14 00:00:00
abstract：:Explosive running is a reliable initial component of audiogenic seizures (AS) induced by acoustic stimulation in genetically prone rodents. This profound locomotor activation is usually considered as a convulsive manifestation of AS although some studies attribute running to a panic-like response. Increase in central ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.02.017
更新日期：2007-05-07 00:00:00
abstract：:Lithium is known to potentiate the ability of pilocarpine to induce status epilepticus in rats. The goal of this study was to determine whether lithium could potentiate pilocarpine-induced seizures in developing animals. Behavioral, electroencephalographic (EEG), and histopathological changes induced by systemic admin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(10)80015-0
更新日期：1992-06-26 00:00:00
abstract：:This study compared whether activation of muscle ergoreceptor afferents caused by isometric muscle contraction, activation of baroreceptor afferents induced by i.v. infusion of phenylephrine, or baroreceptor afferent inactivation, caused by carotid artery occlusion, elicit similar patterns of c-Fos induction in brains...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02217-9
更新日期：2000-01-10 00:00:00
abstract：:Field potentials (FP) recorded from the surface of toad's optic tectum (OT) to electrical stimulation of the contralateral optic nerve (ON) show initial positive deflections P*, followed by negative wave N and positive wave P; the former result from axonal inputs, the latter two resemble excitatory and inhibitory post...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01260-o
更新日期：1995-01-09 00:00:00
abstract：:The ultrastructural features of the serotoninergic innervation of the rat dentate gyrus in normal adults and in animals receiving raphe nuclear area transplants was investigated using an antibody to serotonin (5-HT). Neonatal rats received a lesion of the fimbria-fornix and entorhinal cortex. Three days later, a porti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90509-3
更新日期：1986-03-26 00:00:00
abstract：:Stereotaxic microinjections of the excitotoxin, ibotenic acid, were made into the striatum, hippocampus or cerebellum of the immature (7-day-old) rat. Two days later, pups were decapitated and the brains processed for light microscopic examination or neurochemical analyses. 10 micrograms ibotenate caused a complete lo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90467-0
更新日期：1984-07-30 00:00:00
abstract：:Lesions of the insular cortex (IC) attenuate acquisition of conditioned taste aversions (CTAs). We have suggested that this impairment is the expected consequence of a failure of IC-lesioned (ICX) rats to recognize unfamiliar taste stimuli as novel. That is, ICX rats treat novel taste stimuli as if they are familiar a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.12.058
更新日期：2009-03-09 00:00:00
