Abstract:
:Repetitive generation of spreading depression (SD) waves may induce metabolic and functional disturbances in the invaded brain regions. In order to better characterize this state, up to 60 SD waves were elicited in the cerebral cortex of anesthetized rats by intracortical injections of 2 microliters of isotonic K-acetate repeated at regular 5-min intervals. Propagation rate of SD between capillary electrodes located 1 mm and 7 mm from the injection site gradually decreased and after 35-45 waves became irregular. In another series of experiments SD-induced changes of cyclic adenosine monophosphate (cAMP) level were examined after 24 SD waves. Although no irregularities of SD propagation were observed, maximum level of cAMP in the SD-invaded cortex decreased from 270% in controls to 170% after 24 waves. Also, the recovery of the nucleotide was slowed down. Metabolic alterations thus preceded irregularities in SD propagation.
journal_name
Brain Resjournal_title
Brain researchauthors
Gorelova NA,Krivánek J,Bures Jdoi
10.1016/0006-8993(87)91399-0subject
Has Abstractpub_date
1987-02-24 00:00:00pages
379-81issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(87)91399-0journal_volume
404pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::An effective animal model for elucidating the neurobiological basis of human smoking should simulate important aspects of this behavior. Therefore, a 23 h unlimited access nicotine self-administration model was used to compare inbred Lewis rats, which have a propensity to self-administer drugs of abuse, to inbred Fish...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03375-3
更新日期:2002-03-15 00:00:00
abstract::The contribution of motor and intralaminar thalamic nuclei to the changes of [3H]GABA release evoked in both caudate nuclei (CN) and both substantia nigra (SN) by a unilateral nigral application of muscimol (10(-6) M) was investigated on halothane-anaesthetized cats. Acute lesions were performed on one side of the tha...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91206-x
更新日期:1984-06-15 00:00:00
abstract::The neurobiology of social bonding, despite its relevance to human mental health, has been studied primarily in rodents. In this study we used position emission tomography (PET), registered with structural magnetic resonance imaging (MRI) to investigate central glucose uptake in 17 males of a monogamous primate specie...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.09.087
更新日期:2007-12-12 00:00:00
abstract::Calretinin-immunoreactive structures in the anterior olfactory nucleus of the rat were studied using a polyclonal antibody, which does not cross-react with the highly homologous calcium-binding protein calbindin-D28k, and the avidin-biotin-peroxidase technique. Calretinin-immunopositive neurons were found in all regio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00023-7
更新日期:1998-04-06 00:00:00
abstract::Performance on object recognition and object placement memory tasks was evaluated after a short-dosing model of methamphetamine (MA) regime and monoamines and metabolites were measured post-testing. Adult male rats received three injections of 10 mg/kg at 2-h intervals. In striatum DA and 5-HT were depleted by 65% and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02599-4
更新日期:2002-06-14 00:00:00
abstract::The cortex receives a cholinergic input which is considered to be involved in mediating the effects of arousal. The experiments reported here have examined the nature of the cholinergic influence on the neuronal organization of the cat visual cortex. Out of 83 cells studied, 92% exhibited a modification in their visua...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90015-x
更新日期:1983-12-19 00:00:00
abstract::MicroRNAs (miRNAs) are abundantly expressed in the brain and play an important role in disorders of the brain, including Alzheimer's diseases (AD). Growing body of evidence suggests that the TGF-β signaling pathway plays a key role in the pathogenesis of AD. However, it is unclear whether miRNAs involved in AD pathoge...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.08.023
更新日期:2010-10-21 00:00:00
abstract::Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the vertebrate brain. GABA activates both ionotropic (GABA(A)) and metabotropic (GABA(B)) receptors in mammals. Whether non-mammalian vertebrates possess receptors with similar characteristics is not well understood. We used a mammalian GABA(B)-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.03.008
更新日期:2006-06-13 00:00:00
abstract::Brain serotonin (5-HT) uptake sites were quantitated, by saturation binding of [3H]paroxetine, in 10 brain regions from 22 suicide victims and 20 control subjects. Suicide victims were restricted to those subjects in whom a firm retrospective diagnosis of depression was established and who had not recently been prescr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90244-6
更新日期:1990-08-27 00:00:00
abstract::The present study was designed to test the hypothesis that a major excitatory mechanism for the expression of feline defensive rage behavior involves the medial nucleus of the amygdala which utilizes substance P as a neurotransmitter in a direct output pathway that supplies the medial hypothalamus. In phase I of the e...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91070-9
更新日期:1993-10-22 00:00:00
abstract::Mild cognitive impairment (MCI) is considered the transitional stage between normal cognition and dementia. The aim of this study was to use tractography based analysis to elucidate alterations in subjects with MCI compared with subjects with early Alzheimer's disease (AD) and controls. Seventeen subjects with early A...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.06.052
更新日期:2009-09-01 00:00:00
abstract::We measured the release of neuropeptide Y (NPY) from hippocampal slices of rats at various times after limbic seizures induced by a subcutaneous injection of 12 mg/kg kainic acid (KA). Two days after KA, 100 mM KCl induced a 1.6 +/- 0.2-fold increase in NPY release compared to saline-injected rats (P < 0.05), while sp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90847-8
更新日期:1994-10-10 00:00:00
abstract::The electrophysiological effects of the non-competitive N-methyl-D-aspartate (NMDA) antagonist (+)-MK-801 (MK-801) on nigrostriatal and mesoaccumbal dopaminergic (DA) neurons were evaluated in chloral hydrate-anesthetized rats. MK-801 (0.05-3.2 mg/kg, i.v.) stimulated the firing rates of 14 (74%) of 19 nigrostriatal D...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91091-r
更新日期:1992-09-11 00:00:00
abstract::Immunohistochemical localization of the decapeptide gonadotropin releasing hormone (GnRH) in neural structures in the pony brain and infundibulum (INF) was conducted at the light-microscopic level. This procedure utilized an antiserum generated against GnRH conjugated to bovine serum albumin. In the rostral INF, GnRH ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90625-9
更新日期:1981-03-09 00:00:00
abstract::The importance of particular genes in neuronal death following global cerebral ischemia can readily be studied in genetically modified mice provided a reliable model of ischemia is available. For that purpose, we developed a mouse model of global cerebral ischemia that induces consistent damage to different regions of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)03014-2
更新日期:2003-08-29 00:00:00
abstract::Many of the behavioral consequences of dopamine system activation are thought to be mediated by substantia nigra pars reticulata output pathways. Extracellular, single unit recording studies were conducted to determine how i.v. administration of the dopamine agonist, apomorphine, affects the activity of these pars ret...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90380-9
更新日期:1984-07-23 00:00:00
abstract::Damage to the medial temporal lobe (MTL) and diencephalon results in impaired long-term memory, which relies on the binding of multiple, mostly contextual, features. Recent neuroimaging and patient studies have suggested that impairments may also be present in working memory after MTL or diencephalic damage. To examin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.07.066
更新日期:2007-10-03 00:00:00
abstract::We measured expression of the oxytocin gene in the supraoptic nucleus (SON) during pregnancy, parturition and lactation to examine its relationship to states of accumulation or depletion of oxytocin stores and to conditions of strong excitation of oxytocin neurons. The primary transcript (heterogeneous nuclear RNA, hn...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01275-4
更新日期:1998-01-26 00:00:00
abstract::Perceptual performance in persons with hearing loss, especially those using devices to restore hearing, is not fully predicted by traditional audiometric measurements designed to evaluate the status of peripheral function. The integrity of auditory brainstem synapses may vary with different forms of hearing loss, and ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.02.012
更新日期:2015-04-24 00:00:00
abstract::The glutamate terminals in rat rostral neostriatum were removed on one side by ipsilateral frontal cortical ablation. Intraperitoneal administration of L-methioninesulfoximine (MSO), an inhibitor of glutamine synthetase, induced different changes in amino acid concentration in the rostral neostriatum on the intact and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90261-6
更新日期:1985-07-08 00:00:00
abstract::We observed temporal changes in NACP (precursor protein of non-Abeta component of Alzheimer's disease amyloid), a presynaptic protein a.k. a. alpha-synuclein, in the hippocampus after 5 min ischemia. Intense NACP immunoreactivity was seen transiently around cerebral blood vessels in the CA1 subfield on day 4, and NACP...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00033-x
更新日期:1998-03-30 00:00:00
abstract::Some afferent fibers from the pudendal nerve of the female cat were stimulated by pressing on the perineal skin, the vagina or the uterine cervix. Three different types of skin mechanoreceptors were found: (1) with low threshold (< 20 mg) and slow-adapting discharges; (2) with high threshold (0.1-0.5 g) and slow-adapt...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91589-x
更新日期:1994-08-29 00:00:00
abstract::The aim of this work was to characterize the interaction of the Na+-channel toxin, purified from venom of the scorpion Leiurus quinquestriatus, with microtubule proteins in vitro. The toxin enhanced microtubule assembly, causing the formation of microtubule 'bundles'. It interacted with the Na+-channel 270 kDa subunit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0169-328x(86)90019-7
更新日期:1986-07-01 00:00:00
abstract::The distribution of neural elements immunoreactive to several peptides with a possible messenger role was studied in the lamprey spinal cord by using an indirect immunofluorescence method. Different patterns of immunoreactive (IR) fibers were detected by antisera raised against cholecystokinin, metorphamide, bombesin,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90392-1
更新日期:1987-04-07 00:00:00
abstract::The effects of streptozotocin-induced diabetes mellitus on the activity of discrete regions of the brain were studied with histochemical localization and photodensitometric quantification of the metabolic enzyme, hexokinase. Two weeks after a single injection of streptozotocin (65 mg/kg, i.p.), plasma glucose and osmo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91593-6
更新日期:1990-07-02 00:00:00
abstract::The effect of intracerebroventricular administration of dizocilpine on feeding behaviour and adrenal corticrotropic hormone (ACTH)-induced anorexia in elevated plus maze was examined. Dizocilpine (10, 20 and 40 nmol/rat, i.c.v.) showed a dose-dependent increase in food intake in 16 h food deprived rats. Dopamine recep...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00990-1
更新日期:1998-11-23 00:00:00
abstract::Brief force perturbations were applied 30-120 ms prior to onset of step-tracking forearm movements by normal humans. The perturbations altered the first agonist burst of the movement-related triphasic EMG pattern. Perturbations opposing the movement resulted in an increase in the magnitude of the late part of the firs...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)91224-5
更新日期:1981-09-14 00:00:00
abstract::Equivalent antiinflammatory doses of steroids including betamethasone, methylprednisolone and dexamethasone were administered in the neonatal period in a rat model. In situ cell death in hippocampus quantified by Terminal Deoxynucleated Transferase Nick-End Labeling and on ratio of brain to body weight was investigate...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.10.051
更新日期:2009-01-23 00:00:00
abstract::Male rats were treated with barbital in their drinking fluid for about 40 weeks (daily dose 200 mg/kg). The treatment was stopped on day 0 and the number of muscarinic binding sites was measured in 3 brain parts (striatum; cortex and hippocampus; medulla oblongata and midbrain) during the abstinence with labeled quinu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90146-9
更新日期:1982-08-19 00:00:00
abstract::We studied the short- and long-term epileptogenic effects of massed stimulation (MS) of the piriform cortex. Sprague-Dawley rats with electrodes implanted bilaterally in the anterior piriform cortex and the dorsal and ventral hippocampi underwent MS: electrical stimulation of the left piriform cortex every 5 min for 6...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00071-1
更新日期:1997-04-18 00:00:00